Pulm HTN Drugs Flashcards
1
Q
epoprostenol
A
- mimics the actions of endogenous prostacyclins, by activating G-PCRs to generate cAMP
- lowers pulmonary artery resistance, decreased pressure
- must be given continuous IV infusion d/t short t1/2
- HA, Flushing, Hypotension
2
Q
treprostinil
A
- mimics the actions of endogenous prostacyclins, by activating G-PCRs to generate cAMP
- lowers pulmonary artery resistance, decreased pressure
- longer t1/2
- SubQ pain/Cough
3
Q
iloprost
A
- mimics the actions of endogenous prostacyclins, by activating G-PCRs to generate cAMP
- lowers pulmonary artery resistance, decreased pressure
- administered by inhalation 6-9x/day
- HA, Flushing, Hypotension
4
Q
selexipag
A
- mimics the actions of endogenous prostacyclins, by activating G-PCRs to generate cAMP
- lowers pulmonary artery resistance, decreased pressure
- administered orally BID
- HA, Flushing, Hypotension
5
Q
sildenafil
tadalafil
A
- selectively blocks PDE type V to prevent the breakdown of cGMP
- causes smooth muscle relaxation, improves exercise tolerance, and slows symptom progression in PAH
- Oral
tadalafil longer half life
6
Q
bosentan
macitentan
A
- nonspecifically blocks ETa and ETb endothelin receptors
- improves exercise tolerance and slows symptom progression in PAH
- administered orally
- risk of hepatotoxicity, teratogenesis
- increases metabolism of warfarin and oral contraceptives (must use 2 forms of birth control!!)
macitentan: long half life for 1x/day dose
7
Q
ambrisentan
A
- selectively blocks ETa endothelin receptor
- improves exercise tolerance and slows symptom progression in PAH
- administered orally
- risk of teratogenesis
- does not accelerate metabolism of warfarin or oral contraceptives, but pt must still use 2 forms of birth control!!
8
Q
riociguat
A
- stabilizes guanylate cyclase and NO binding, leading to increased cGMP and increased vasodilation
- improves exercise tolerance and slows symptom progression in PAH
- administered orally
- risk of hypotension, fetal harm, headache, dizziness
