Pulm Flashcards
Obstructive diseases
Asthma
COPD
Bronchiectasis
CF
Restrictive Diseases
Sarcoidosis
IPF
Penumoconiosis
Asthma Samters Triad
Asthma
Nasal Polyps
NSAID allergy
Asthma Sx
dyspnea, wheezing, cough (worse at night)
Asthma PE
Prolonged expiration with wheezing
Hyperresonance to percussion
Decreased breath sounds
Status Asmaticus
Inability to speak in full sentences, AMS, pulsus paradoxis
Asthma Dx
Gold Standard: PFT
Methacholine challenge test
Bronchodilator challenge
PFT in asthma
decreased FEV1, decreased FEV1/FVC
Methacholine challenge in asthma
> /= 20% decrease in FEV1
Tx acute asthma
- SABA: albuterol (bronchodilators, nebs q20 min x3)
- Anticholinergics: Ipratropium
- Corticosteroids: Prednisone, prednisolone, methylprednisone (3-5d)
Tx chronic asthma
Start with SABA PRN then add an ICS (beclamthasone, Flunisolide) then add LABA (Salmeterol/fometerol)
Leuko Modifiers if allergies are causing asthma
IV mag if uncontrolled severe
Acute Bronchitis etiology
MC cause: ADENOVIRUS, parainfluenza
Inflam of trachea/bronchi often post URI
Hallmark is cough 1-3 weeks
Bronchitis dx/ tx
Clinical usually, CXR is nonspecific
Tx: TOC is sx tx
- fluids
- rest
- antitussives
Bronchiectasis etiology
Recurrent/chronic lung infections: H. Flu (MC)
CF usually Pseudomonas
Bronchiectasis sx
Daily chronic cough with thick, mucopurulent, foul-smelling sputum
Hemoptysis
Bronchiectasis Dx
CT scan TOC: Dilated airway, bronchial wall thickening
TRAM TRACKS
PFT: obstructive pattern (decreased)
Signet Ring Sign
pulmonary artery coupled with dilated bronchus
Bronchiectasis Tx
Abx TOC
- empiric ampicilin, amox, bactrim
- pseudomonal fluoroquin, pip/tazo
Bronchodilators for mucus management
Bronchial Carcinoid tumors etiology
Enterochromaffin cells
MC in GI tract, lung is 2nd MC
Can secrete serotonin/ACTH/ADH/melanocyte stim hormone
Bronch Tumor sx
focal wheeze, cough, recurrent PNA, hemoptysis
SIADH, Cushing’s syndrome
Carcinoid syndrome
diarrhea d/t increased serotonin, increased bradykinin and histamine –> flushing, tachycardia, bronchoconstriction
Bronch Carcinoid tumor Dx/ Tx
Bronchoscopy
Tx: Surgical excision is definitive
Octreotide to reduce sx
COPD etiology
progressive, irreversible airflow obstruction d/t loss of elastic recoil and increased resistance
Emphysema + Bronchitis
COPD rsk fx
Sm MC
Alpha 1 antitrypsin deficiency: genetic <40yo
Emphysema
abn, permanent enlargement of terminal airspaces
Loss of elastic coil and increased compliance
PINK PUFFER: cachectic, hypoxemia, CO2 normal
Chronic Bronchitis
Productive cough >3 months for 2 consecutive years
BLUE BLOATERS: obese, cyanotic
COPD PFT
GOLD STANDARD
FEV1<1L = increased mortality
Obstruction
Hyperinflation
COPD CXR/CT
Hyperinflation, flat diaphragm, increased AP diameter
COPD EKG
Cor Pulmonale
Chronic Pulm HTN
Multifocal Atrial Tach
COPD Tx
- Bronchodilators combo with anticholinergics and beta agonists
- TOC for stable COPD - Corticosteroids NOT monotherapy
- Oxygen (only therapy to reduce mortality)
Use oxygen in COPD if…
Cor Pulmonale
O2 sat <88%
PaO2<55mmHg
Anticholinergics
Tiotropium (preferred over beta 2 agonists)
SE: dry mouth, thirst, blurred vision, urinary retention
CI: BPH severe glaucoma
B2 agonists
Albuterol, terbutaline, salmeterol
SE: B1 cross reactivity, tachycardia, tremor
CI: severe CAD, caution in DM
Corticosteroids SE
osteoporosis
thrush
increased infections
hyperglycemia
GOLD staging
Mild: FEV1/FVC <0.70, FEV1 >80%
Moderate: FEV1/FVC <0.70, FEV1 50-79%
Severe: FEV1/FVC <0.70, FEV1 30-49%
Very Severe: FEV1/FVC <0.70, FEV1 <30%
Cor Pulmonale
Long standing pulm HTN -> R vent hypertrophy, R atrial enlargement, R axis deviation, R sided HF, seen especially with chronic bronchitis, multifocal atrial tach
Hypoventilation Syndrome (OHS) etiology
Awake alveolar hypoventilation in an OBESE individual which cannot be attributed to other conditions
OHS rsk fx
BMI >30
Central Obesity
Severe OSA: daytime hypersomnolence, loud snoring, choking during sleep, fatigue, small oropharynx, tick neck
OHS labs
elevated serum bicarb
Hypercapnea: pa CO2 >45mmHg
Hypoxemia: PaO2 <70mmHg
Polycythemia
OHS DX (DOE)
CXR: elevation of both hemidiaphragm and heart may be enlarged due to R vent hypertrophy
OHS Tx
1st line: CPAP/BiPAP, weight loss, lifestyle mods
2nd line: tracheostomy, bariatric surg
Idiopathic Pulm Fibrosis etiology
Chronic progressive interstitial scarring from persistent inflammation
Dyspnea +/- nonproductive cough
IPF PE/Dx
Fine basilar INSPIRATORY crackles, clubbing, cyanosis
Dx:
CXR: diffuse opacities, honeycombinb, ground glass
PFT: restrictive disease
IPF Tx
No effective treatment, smoking cessation, O2, corticosteroids maybe?
Lung transplant is only cure
Pneumoconiosis etiology
chronic fibrotic lung disease 2/2 to inhalation of mineral dust
Silicosis
Mining/Pottery
Dyspnea on exertion, nonproductive cough
CXR: multiple small round nodular opacities, primary in the upper lobes, eggshell calcifications
Tx: supportive
Coal Workers pneumoconiosis
Coal/Carbon mines
CXR: small upper lobe nodules and hyperinflation, may have Obstructive PFT
Caplan Syndrome: coal workers pneumoconiosis + RA
SUPPORTIVE TX
Berylliosis
electronics, aerospace, ceramics, tool/dye manufacturing
Sx: Dyspnea, cough, arthralgia, weight loss, fever
CXR: increased interstitial lung markings
Dx: + exposure, +beryllium proliferation test
+noncaseating granulomas on biopsy
Tx: corticosteroids, O2, Supportive
Asbestosis etiology
Seen in 15-20 years after long term sbestos
Increased risk bronchogenic carcinoma, malignant mesothelioma of the pleura
Asbestosis dx/ tx
CXR: pleural plaques, interstitial fibrosis, primarily in LOWER lobes
Shaggy Heart Sign: blurring of diaphragm/heart border
Biopsy: linear asbestos bodies in lung tissue
SUPPORTIVE
Pulm HTN etiology / pathophys
Pulm MAP >/= 25mmHg
Increased vascular resistance / RVH
Pulm HTN Sx
Dyspnea, CP, weakness, fatigue, cyanosis, edema
Pulm HTN PE
Accentuated S2, fixed or paradoxically split P2
Signs of R heart failure (increased JVP, peripheral edema, ascites)
Systolic ejection click, pulm regurg
Pulm HTN Dx
GOLD STANDARD: right side heart cath
CBC: polycythemia, elevated Hct
CXR: enlarged pulm arteries
EKG: cor pulmonale, RVH, right axis deviation, RBBB
Echo: large right ventricle, right atrial hypertrophy
Pulm HTN Tx
Primary: CCB
Type II / III: tx underlying disease
Pulm Nodules etiology
<3cm
Mass >3cm
Granulomatous infections: TB
Tumors
Inflamm: RA, sarcoidisis
Mediastinal tumors: thymoma
Pulm Nodules Dx
Obs if low malignant probability
Needle Aspiration or bronchoscopy for peripheral lesions
Resection w/ biopsy if malignancy
Sarcoidosis etiology
Chronic multisystem, inflammatory, granulomatous, disorder of unknown etiology
Exaggerated T cell response
Sarcoidosis Sx
50% asx Dry cg, dyspnea, cp Anterior Uveitis: blurred vision, photophobia, floaters Arrythmias Arthralgias Cranial Nerve Palsies
Sarcoidosis skin sx
2nd MC organ involved
- Erythema nodosum anterior legs
- Lupus pernio: nose, ears, cheeks, chin
- Maculopapular rash: MC rash of sarcoidosis
- Parotid gland enlargement
Sarcoidosis Dx
Compatible clinical radiologic findings
Noncaseating granulomas
Exclusion of other diseases
CXR: bilateral hilar LDA
Sarcoidosis Tx
Obs, oral corticosteroids