Pulm Flashcards
Main difference between asthma and COPD
reversibility
How to take temp in asthma exacerbation
not orally– mouth breathing cools thermometer
Associations with asthma
atopy, obesity
Asthma patients are worst at _____, sensitize to ___.
Worst at night, sensitive to ASA
PE findings in asthma
wheezes and *prolonged expiratory phase
Asthma:
best initial test
most accurate test
best test for asx patient
Peak flow- initial
Accurate- PFTs
Asx- FEV1 decrease with methacholine (challenge)
PFT finding in asthma
FEV1/FVC low, reversible with albuterol
How should PFTS be affected by methacholine and albuterol in asthma?
FEV1 ^ 12% with albuterol
FEV1 down 20% with methacholine)
What is methacholine?
acetylcholine– increases secretions
Appropriate asthma treatment (stepwise)
1) SABA
2) SABA + ICS
3) SABA + ICS + LABA
4) “” but ^ dose/ strength of ICS
5) SABA+ ICS + LABA + Omalizumab
6) SABA + ICS + LABA + Omalizumab + OCS
Common combined inhalers:
bronchodilator
inhaled corticosteroid
(Advair and symbicort are both LABA + ICS)
What are some of the low dose inhaled steroids?
- beclomethasone
- budesonide
- fluticasone
What are the two SABAs?
albuterol/levalbuterol
pirbuterol
*LABAs are others ending in erol
Metabolic effects of oral steroids
- ^glucose
- ^lipids
- osteoporosis
Which of the asthma meds should never be used first/ alone?
LABAs
Role of anticholinergics in asthma?
not. none. They are for COPD
Special vaccines for asthmatics
all get pneumo and influenza. Gotta do it.
Best clinical indication of asthma severity
RR
Treatment of asthma exacerbation
O2
bolus of IV steroids
albuterol nebs
**No epi. Bad news.
Alternative to albuterol in asthma attack when albuterol not effective
mag
COPD- effect on TLC and DLCO
increased TLC– hyperinflation
decreased DLCO- destruction
Young nonsmoker with COPD has
a1at mutation
CBC change in COPD
high hct from chronic hypoxia
EKG findings in COPD
RAE (tall P wave V1); RVH; MAT
What improves mortality in COPD
O2; smoking cessation; vaccines
When to give supplemental O2?
60/90 pO2/sat with right heart disease, high HCT etc… 55/88 if otherwise healthy
Medications for COPD
1) SABA PRN
2) SABA PRN + anticholinergic
3) SABA PRN + antichol + ICS
4) transplant
How is COPDE treated differently than asthma?
add abx
Drugs for COPDE/asthma exacerbation
albuterol nebs, O2, IVCS
+ abx for COPDE
Options for Abx in COPDE
1) macrolides
2) augmentin
3) quinolones
4) 2nd gen ceph
What the hell is bronchiectasis anyways?
chronic dilation of large bronchi…permanent anatomic abnormality (esp common with CF/ repeated infections)
Clinical clue to bronchiectasis
recurrent large volume sputum production (due to large bronchi that allow pooling of secretions)
so coughing shit up all day errday
How to dx bronchiectasis
tram tracks on high rest chest CT
Px treatment for bronchiectasis
cupping and clapping (chest phys therapy)
ABPA what is it?
Allergic Bronchopulmonary Aspergillosis
allergy patient… gets exposed to aspergillus/fungus and has hypersensitivity dx
Clinical clues to ABPA:
brown flecked sputum
transient infiltrates on CXR
Treatment of ABPA
oral steroids (not inhaled)
Principal pathophys of CF
thick sputum, no mucus clearance, bacteria takes shop
Sinus finding in CF
nasal polyps
GI assc with CF
- recurrent pancreatitis/ no pancreatic digestive enzymes
- meconium ileus
- biliary colic
- instestinal obstruction
GU involvement in CF
-azospermia
-20% missing vas
-altered menstrual cycle
-mucus blocks sperm through cervix
(all infertile)
Best test for CF
increased sweat chloride
CF PFT findings
mixed obstructive and restrictive
low TLC, DLCO, TLC
Treatment options for CF
- inhaled aminoglycosides, rhDNase, and SABA
- vaccines
- ivactafor (some patients)
- transplant
Bug causing pneumonia in vet/farmer/animal birth
coxiella
Bug causing pneumonia in contaminated water/ heating and cooling etc
listeria
Bug assc with DM and alcoholism (causing PNA)
klebsiella
Dull percussion in PNA=
effusion
PNA assc with:
currant jelly sputum
rotten egg sputum
CNS symptoms
Klebsiella- currant jelly
rotten egg- anerobes
CNS-listeria
Infections with dry cough + bilateral interstitial infiltrates
mycoplasma coxiella pneumocystis virus chlamydia
Empyema findings on thoracentesis
LDH more than 60% serum Protein more than 50% serum White count more than 1000 pH less than 7.2 (any of these)
What are the respiratory FQs
levo moxi
Outpatient treatment of CAP
macrolide or doxy unless sickly/recent abx then FQ
Inpatient treatment of CAP
etither ceftriaxone + macrolide or FQ
Two factors that are in isolations reasons to admit PNA patient
hypoxia
hypotension
What are CURB65 criteria for admission?
C-confusion U-uremia R-respiratory distress B-BP low 65+ 2+ points admit
How long between 13 and 23 valent PNA vaccines
6-12 months
Reasons to give PNA vaccine early
asplenia hematologic cx immunosupressions (steroids, DM, HIV, alcohol) CSF leak, cochlear implant heart, liver, kidney, lung disease
Bugs at risk in HAP and main difference in treatment
ecoli and pseudomonas —> cannot use macrolides
Treatments for HAP
cefepime/ceftaz, pip tazo, or carbapenems
What are the antipseudomonal blactams
ceftaz, cefepime
piptazo
carbapenems
Treatment of VAP
3 agents
antipseudomonal B lactam + vanc or linezolid + FQ or AG
Why no dapto for lungs?
inactivated by surfactant
Imipenem ADR
seizures
Lung Abscess:
key sx
dx
tx
foul sputum
lung bx
clinda or penicillin
CD4 count where patients get PCP
200 or less
Lab test clue to PCP
LDH levels always elevated
1st line tx for PCP
Bactrim
Alternatives to Bactrim for px and tx of PCP if patient has contraindication
px: atovaquone or dapsone (not in G6PD
tx: clinda + primaquine (not in G6PD) or pentamidine
At what CD4 is px given for the first time in AIDs?
200
What is never a good test for TB in symptomatic patient?
PPD –> instead do sputum culture x 3
Standard empiric treatment for active TB
RIPE x 2 months –> RI x 4 months
6 months total
When to stop TB meds
transaminases 3-5x ULN
Who is considered PPD + at 5mm or more?
When are others +?
5mm: steroids/transplant, HIV, close contact, xray
10 mm: other risks (healthcare, prison etc)
15 mm: no risks
Which RIPE drug causes hyperuricemia?
pyrazinamide
Treatment for first time +PPD
9 months isoniazid even if had BCG vaccine
“Malignant” features in lung nodule:
40+ enlarging or 2+cm; smoker; spikulated; adenopathy; etc.
What to do when solitary nodule has many malignant features
remove
What to do for “grey area” nodules?
bronch/biopsy in most; can also do PET, sputum cytology, VATS
What to do for low risk lesions?
surveillance
PE findings for pulmonary fibrosis
dyspnea, crackles, P2, clubbing
Dx of pulm fibrosis
CXR –> CT –> bx
EKG/ echo findings in pulm fibrosis
RVH –> PHTN
Bx finding in berylliosis
granulomas
PFT findings in pulmonary fibrosis
normal FEV1/FVC ratio; decreased DLCO
Treatment for pulm fibrosis
steroids
Oddball systemic findings assc with sarcoid
- facial palsy
- parotid gland hypertrophy
- heart block
- uveitis
- CNS changes
CXR clue in sarcoid
hilar lymphadenopathy
PFTs in sarcoid have what pattern?
restrictive
Labs in Sarcoid
high ACE, calciuria, calcemia
Treatment of sarcoid
steroids only if symptomatic
CXR, EKG, ABG findings in PE
clear lungs/ wedge infarct, sinus tach, respiratory alkalosis
Appropriate imaging for PE
spiral CT unless pregnant then VQ scan
What test is avoided in case of PE due to mortality
angiography
Appropriate treatment for thromboembolism
heparin –> warfarin to INR of 2-3
Alternative to heparin for TE
fonduparinox
When is IVC ok?
absolute CI to heparin
recurrent emboli on heparin/warfarin
RV dysfunction
When are thrombolytics appropriate for TE?
unstable/ acute RV dysfunction
Heart sounds assc with PHTN
- wide split S2
- loud P2
- TR/PR possible
Definition of PHTN
PA pressures above 25/8
Treatment of idiopathic HTN
- prostacyclin analog (tenol/tinil/prost)
- endothelin antag (sentan)
- PDEi (sildenafil)
Cure for PHTN
lung transplantation
Sleep apnea + increased bicarb=
obesity hypoventilation syndrome
Causes of ARDS
- sepsis/aspiration
- contusion/ trauma
- drowning
- pancreatitis
- burns
ARDS definition
pO2/FIO2 below 300
Vent settings for ARDS
high PEEP low TV (6) and plateau pressure less than (30)