Pulm Flashcards
Main difference between asthma and COPD
reversibility
How to take temp in asthma exacerbation
not orally– mouth breathing cools thermometer
Associations with asthma
atopy, obesity
Asthma patients are worst at _____, sensitize to ___.
Worst at night, sensitive to ASA
PE findings in asthma
wheezes and *prolonged expiratory phase
Asthma:
best initial test
most accurate test
best test for asx patient
Peak flow- initial
Accurate- PFTs
Asx- FEV1 decrease with methacholine (challenge)
PFT finding in asthma
FEV1/FVC low, reversible with albuterol
How should PFTS be affected by methacholine and albuterol in asthma?
FEV1 ^ 12% with albuterol
FEV1 down 20% with methacholine)
What is methacholine?
acetylcholine– increases secretions
Appropriate asthma treatment (stepwise)
1) SABA
2) SABA + ICS
3) SABA + ICS + LABA
4) “” but ^ dose/ strength of ICS
5) SABA+ ICS + LABA + Omalizumab
6) SABA + ICS + LABA + Omalizumab + OCS
Common combined inhalers:
bronchodilator
inhaled corticosteroid
(Advair and symbicort are both LABA + ICS)
What are some of the low dose inhaled steroids?
- beclomethasone
- budesonide
- fluticasone
What are the two SABAs?
albuterol/levalbuterol
pirbuterol
*LABAs are others ending in erol
Metabolic effects of oral steroids
- ^glucose
- ^lipids
- osteoporosis
Which of the asthma meds should never be used first/ alone?
LABAs
Role of anticholinergics in asthma?
not. none. They are for COPD
Special vaccines for asthmatics
all get pneumo and influenza. Gotta do it.
Best clinical indication of asthma severity
RR
Treatment of asthma exacerbation
O2
bolus of IV steroids
albuterol nebs
**No epi. Bad news.
Alternative to albuterol in asthma attack when albuterol not effective
mag
COPD- effect on TLC and DLCO
increased TLC– hyperinflation
decreased DLCO- destruction
Young nonsmoker with COPD has
a1at mutation
CBC change in COPD
high hct from chronic hypoxia
EKG findings in COPD
RAE (tall P wave V1); RVH; MAT
What improves mortality in COPD
O2; smoking cessation; vaccines
When to give supplemental O2?
60/90 pO2/sat with right heart disease, high HCT etc… 55/88 if otherwise healthy
Medications for COPD
1) SABA PRN
2) SABA PRN + anticholinergic
3) SABA PRN + antichol + ICS
4) transplant
How is COPDE treated differently than asthma?
add abx
Drugs for COPDE/asthma exacerbation
albuterol nebs, O2, IVCS
+ abx for COPDE
Options for Abx in COPDE
1) macrolides
2) augmentin
3) quinolones
4) 2nd gen ceph
What the hell is bronchiectasis anyways?
chronic dilation of large bronchi…permanent anatomic abnormality (esp common with CF/ repeated infections)
Clinical clue to bronchiectasis
recurrent large volume sputum production (due to large bronchi that allow pooling of secretions)
so coughing shit up all day errday
How to dx bronchiectasis
tram tracks on high rest chest CT
Px treatment for bronchiectasis
cupping and clapping (chest phys therapy)
ABPA what is it?
Allergic Bronchopulmonary Aspergillosis
allergy patient… gets exposed to aspergillus/fungus and has hypersensitivity dx
Clinical clues to ABPA:
brown flecked sputum
transient infiltrates on CXR
Treatment of ABPA
oral steroids (not inhaled)
Principal pathophys of CF
thick sputum, no mucus clearance, bacteria takes shop
Sinus finding in CF
nasal polyps
GI assc with CF
- recurrent pancreatitis/ no pancreatic digestive enzymes
- meconium ileus
- biliary colic
- instestinal obstruction
GU involvement in CF
-azospermia
-20% missing vas
-altered menstrual cycle
-mucus blocks sperm through cervix
(all infertile)
Best test for CF
increased sweat chloride