Pulm 3- TB

Question 1

What is the mechanism of Isoniazid
(INH)?
SE?
DDI?

Answer 1

Attacks cell wall
Hepatitis- Increased LFTs
Neuropathy- Always give with vit B6
Lupus-like syndrome: swollen joints, pain, F, D
DDI: 2C9, 3A4- Warfarin

Question 2

What is the mechanism of Rifampin (Rifadin)?
SE?
DDI?

Answer 2

Attacks cells wall
N, Anorexia, Discoloration of body fuids (red/orange)
DDI: 3A4, others

Question 3

What is the mechanism of Rifabutin
(Mycobutin)?
SE?

Answer 3

Neutropenia, leukopenia, thrombocytopenia, Inflammation of Uvea (eye), HepatoTox, Flu-like Sx, discolored body fluids

Question 4

What is the mechanism of Rifapentine
(Priftin)?
SE?
DDI?

Answer 4

Attacks cell wall
N, Anorexia, Discoloration of body fuids (red/orange)
DDI: 3A4, others

Question 5

What is the mechanism of Pyrazinamide?
SE?
DDI?

Answer 5

Attacks cell wall
HepatoTox
N/V
Hyperuricemia -> Gout Attack
Monitor LFTs, uric acid

Question 6

What is the mechanism of Ethambutol?
SE?
DDI?

Answer 6

Attacks cell wall
Optic neuritis -> Irreversible blindness
HA, Neuropathy, confusion, rashes, hepatotox
Monitor LFTs, baseline vision
DDI with antacids 4H apart

Question 7

What is the mechanism of Amantadine
(Symmetrel)?
Indication?
DDI?
SE?

Answer 7

Antiviral- Blocks virus from uncoating, blocks replication
SE: CHF, arrhythmia, agranulocytosis, SZ,
MANY MORE
Many influenza strains immune to
DDI: With KCl, Dig, Anti-Ach

Question 8

What is the mechanism of Rimantadine
(Flumadine)?
SE? Use?

Answer 8

Anti-viral, MOA unknown
SE: SZ, Depression, Bronchospasm
Not effective

Question 9

What is the mechanism of Zanamivir
(Relenza)?
SE?
Caution?

Answer 9

Antiviral
Stops release of virus from cells- neuraminadase
SE: Bronchospasm
SJS, SZ, HA, C, ENT infection
\+ Live flu vax -> less effective

Question 10

What is the mechanism of Oseltamivir
(Tamiflu)?
SE?
DDI?

Answer 10

Antiviral
Inhibits release of neuraminidase
Stops release of virus from cells
SE: Abd pain, epistaxis, Insomnia, delirium
+Probenecid (gout)-> up level of Tamiflu
+ Clopidogrel (Plavix) -> decrease tamiflu

Question 11

What is the mechanism of Peramivir?
SE?
DDI?

Answer 11

Antiviral
Inhibits neraminidase
SE: Delirium, SJS, D, Hyperglycemia
Elevated LFTS
\+ live flu vax -> decrease effectiveness