PUD

Question 1

Misoprostol
MOA
Therapeutic uses
Pharmacokinetics
Adverse effects

Answer 1

Mechanism of action
•Misoprostol has two functions that make it a useful protective agent.
•It directly inhibits gastric acid secretion by parietal cells and,
• it facilitates PGE-mediated mucosal defences and healing in response to acid-related injuries.

Therapeutic uses.
• Misoprostol is used to treat gastric ulceration when caused or aggravated by NSAIDs drugs.

Pharmacokinetics.
• Approx. 90% of the drug is readily absorbed from the GI tract where a significant amount is metabolized via a first-pass hepatic effect.
•The presence of food and antacids will delay drug absorption. Metabolites and small amounts of parent drug are excreted in urine. The duration of action is 3–6 hours.

Administration.
•Misoprostol is given orally three times daily.

Adverse effects.
•Adverse GI signs include:
• diarrhea, vomiting, and abdominal pain.
•It should not be given to pregnant animals as it will promote uterine contractions