PUD Flashcards
1
Q
Gastroc mucosal Defense 3 Level Barrier
A
- PREEPITHELIAL
mucus bicarbonate e phospholipid layer surface epithelial cell - EPITHELIAL
- SUBEPITHELIAL
2
Q
- generates hest shock proteins, trefoil factor family peptides and cathelicidins
- restitution: EGF, TGF, FGF
- has microvascular system that is the key component of subepithelial defense
A
EPITHELIAL SURFACE
3
Q
- 2 Principal gastric secretory products; capable of inducing injury
- plays a role on digestion, absorption of iron and Vit B12 as well as killing bacteria
A
- HCl
- pepsinogen
4
Q
- occurs in basal and stimulated condition
- the basal acid production occur in circadian rhythm (highest level during night, lowest during morning)
A
Gastric Secretion
5
Q
- influence by cholinergic input (vagus nerve) and histaminergic input (local gastric sources)
- somatostatin, cholecystokinin, gherlin, obestatin, secretin, serotonin- plays a role in counterbalancing gastric acid secretion
A
Basal acid production
6
Q
3 Phases of Gastric Secretion
- sight, smell, taste of food
A
- cephalic phase
7
Q
3 Phases of Gastric Secretion
- activated once food enters the stomach
A
gastic phase
8
Q
3 Phases of Gastric Secretion
- initiated as food enters the intestine
A
intestinal phase
9
Q
- located in oxyntic gland
- also important in gastric secretory proceess
- secretes intrinsic factor, IL11
- express several stimulants of acid secretions (histamine 2, gastrin, Ach:M3)
- express receptors for ligands that inhibit acid production (prostaglandins, somatostatin, EGF)
A
Parietal cell
10
Q
- responsible for generating large conc of H+
- consist of alpha (active catalytic site) and beta subunit
- usses chemical energy of ATP to transfer H+ ions from parietal cell cytoplasm to the secretory canaliculi
A
H+, K+- ATPase
11
Q
- found primarily in the gastric fundus
- synthesizes and secretes pepsinogen- inactive precursor of pesin
- pepsin activity significantly diminished at pH 4, irreversibly inactivated and denatured at pH >/=7
A
Chief cell
12
Q
break in the mucosal surface >5mm in size w/ depth to the submucosa
A
Ulcer
13
Q
most common risk factor
A
H. pylori & NSAIDs
14
Q
- often occur in the 1st portion, w/ 90% located w/in 3cm of pylorus
- usually = to 1cm in diameter but occ’l can reach 3-6cm
- sharply demarcated w/ depth at times reaching the muscularis propia
- the base often consist of zone of eosinophilic necrosis w/ surrounding fibrosis
A
Duodenal Ulcer
15
Q
account for the majority of DU
A
H.pylori and NSAID
16
Q
- attributed to either H.pylori or NSAID induced mucosal damage
- gastric acid output tends to be normal or decreased
- abnormalities in resting and stimulated pyloric sphincter pressure w/ increase in duodenal gastric reflux
A
Gastric Ulcer