Chronic Hep 2

Question 1

may follow acute co-infection with

HBV but at a rate no higher than the rate of chronicity of acute hepatitis B.

Answer 1

Chronic hepatitis D virus (HDV)

Question 2

A suggested approach to

therapy for Chronic Hep D

Answer 2

high-dose, long-term IFN for at least a year

Question 3

Regardless of the epidemiologic mode of acquisition chronic hepatitis follows acute hepatitis C in 50−70% of cases. chronic infection is common even in those with a return to normal in aminotransferase levels

Answer 3

Chronic Hep C

Question 4

General clinical features of chronic hepatitis C

Answer 4

• fatigue is the
  mc symptoms
• jaundice is rare

Question 5

Laboratory features of chronic hepatitis C

Answer 5

- similar to those in
patients with chronic hepatitis B
- aminotransferase levels tend to
fluctuate more
-  presence of
autoantibodies

Question 6

is a chronic disorder characterized by
continuing hepatocellular necrosis and inflammation, usually with fibrosis, which can progress to cirrhosis and liver failure

Answer 6

Autoimmune hepatitis

Question 7

The prominence of extrahepatic features of autoimmunity and seroimmunologic abnormalities in this disorder supports an autoimmune process in its pathogenesis; this concept is reflected in the prior labels

Answer 7

lupoid and plasma cell hepatitis

Question 8

Clinical features of autoimmune hepatitis

• onset
• acute hepatitis
• age
• globulinemia
• ANAs

Answer 8

• onset may be insidious or abrupt
• present initially like acute viral hepatitis
• a history of recurrent bouts of
  what had been labeled acute hepatitis is not uncommon
• young to middle-aged women
• marked hyperglobulinemia
• high titer circulating ANAs

Question 9

often seen in children, more
common in Mediterranean populations, and linked to HLA-DRB1 and HLA-DQB1 haplotypes, is associated not with ANA but with anti- LKM

Answer 9

Type II autoimmune hepatitis

Question 10

• is a mononuclear cell infiltrate that, in autoimmune hepatitis, may include the presence of
  plasma cells.
• “rosette” formation

Answer 10

interface hepatitis or piecemeal necrosis

Question 11

mainstay of management in autoimmune hepatitis is

Answer 11

glucocorticoid therapy

Question 12

is not effective in achieving remission, nor is alternate-day
glucocorticoid therapy

Answer 12

Azathioprine alone