Public Health PTS Flashcards
Why is health economics relevant?
Finite resources
Hard choices – some patients will not get something that will benefit them
As a doctor we have to explain this to patients
As a commissioner – will have to decide
What is opportunity cost?
To spend resources on one activity (e.g. heart transplant) means a sacrifice in terms of a lost opportunity cost elsewhere (e.g. fewer hip replacements)
The opportunity cost of an activity is the sacrifice in terms of the benefits forgone from not allocating resources to the next best activity
i.e. if one patient gets a very expensive treatment, others miss out on another treatment
What is economic efficiency?
Achieved when resources are allocated between activities in such a way as to maximise benefit
i.e. if you have £3000 to spend and one treatment costs 1500 compared to another which costs 300, it would be more efficient to go with the cheaper treatment to save more lives/help more people
What is economic equity?
About what is fair and just
Fair and just distribution of costs and benefits
Economists are clear in principle about the definition of efficiency, but there are opposing views about what is ‘fair’
Such considerations are difficult to quantify and the decision making process is much more complex and subjective
What is meant by an equity-efficiency trade-off?
Improving equity often leads to a loss in efficiency
For example – funding the treatment of rare disease with very expensive drugs that may only have a limited benefit
This funding is then not available to treat other people with common diseases where the benefits will be much greater for the same cost
On balance there is a loss of health
This is inefficient, but it’s more equitable
Define economic evaluation
The assessment of efficiency - a comparative study of the costs and benefits of healthcare interventions (i.e. cost benefit analysis)
Costs and effects are analysed in terms of their ‘increments’ or differences
Are the incremental benefits of a new treatment worth the incremental costs?
How can health benefits be measured?
Natural units – e.g. blood pressure/pain score/number of cases detected
Quality adjusted life years
Monetary value
What is a quality adjusted life year (QALY)?
Combines length of life with quality of life
Length (years) x quality (“utility”) weighting (0 to 1 scale)
One QALY = 1 year perfect health
One QALY = 2 years in half perfect health
Allows comparison across diseases
What are the 4 types of economic evaluation?
Cost-effectiveness analysis
Cost-utility analysis
Cost-benefit analysis
Cost-minimisation analysis
What is cost-effectiveness analysis?
Outcomes measured in natural units
E.g. incremental cost per life year gained
What is cost-utility analysis?
Outcomes measured in QALYs
E.g. incremental cost per QALY gained
Remember because the name for quality of life in the QALY eqution is utility
What is cost-benefit analysis?
Outcomes measured in monetary units
e.g. net monetary benefit
What is cost-minimisation analysis?
Outcomes (measured in any units) are the same in both treatments
Therefore, just minimise cost
What is incremental analysis?
Everything is relative
There must always be a comparison – for example:
New drug vs old drug
New treatment vs watch and wait
New surgical option vs medical treatment
What is cost effectiveness analysis?
Simplest form of economic evaluation is cost-effectiveness analysis (CEA)
Uses ‘natural’ units to measure health e.g. life years gained
Comparison across disease areas difficult
Which do you fund:
ICER (heart transplants) = £10,000 per life year gained
ICER (hip replacement) = £3,000 per pain-free year gained
Cost utility analysis?
More complex – using QALYs
Combined length of life and quality of life
In principle, all treatments can be evaluated using CUA – making funding decisions easier
ICER (heart transplants) = £18,000 per QALY
ICER (hip replacements) = £8,000 per QALY
Cost benefit analysis?
Rarely used in healthcare
As it requires putting a monetary value on all outcomes which is difficult
What is a funding threshold?
When a new more experience treatment is funded, another treatment somewhere else in the NHS needs to have its funding stopped to pay for it
NICE thinks that any services that are closed down to fund new services probably generate benefits at around £20,000 per QALY
Taking £20,000 from somewhere else therefore loses 1 QALY
So it only makes sense to fund new things if we get at least 1 QALY per £20,000 (cost must be less than £20,000 per QALY)
What are some other considerations that need to be taken into account in health economics?
Age (equity)
Severity of illness (equity)
End-of-life (equity)
Rarity of condition (equity)
Causation (equity)
Innovation (wider economic benefit)
Patient convinience (and choice)
What are the 3 main models of financing healthcare?
Publicly-funded health systems
Social insurance funded health systems
Privately funded health systems
Define epigenetics
The expression of a genome depends on the environment
Define allostasis
The same as homeostasis
The stability through change of our physiological systems to adapt rapidly to change in environment
Define allostatic load
Long-term overtaxation of our physiological systems leading to impaired health (stress)
Define salutogenesis
Favourable physiological changes secondary to experiences which promote healing and health
Define emotional intelligence
The ability to identify and manage one’s own emotions, as well as those of others
What is the role of primary care?
Managing illness and clinical relationships over time
Finding the best available clinical solutions to clinical problems
Preventing illness
Promoting health
Managing clinical uncertainty
Getting the best outcomes with available resources
Working in the primary health care team
Shared decision making with patients
What are the main dangers of over-prescribing antibiotics?
Unnecessary side effects
Medicalisation of self-limiting conditions
Antibiotic resistance
What criteria should be used for prescribing antibiotics to someone with a sore throat?
CENTOR criteria
What are the centor criteria?
Tonsillar exudate
Absence of cough
Tender or large cervical lymphadenopathy
Fever
What are some other criteria for when to prescribe antibiotics?
Bilateral otitis media < 2 years old
Otitis media with otorrhoea
Acute sore throat with ≥ 3 centor criteria
Systemically very unwell
High risk – e.g. comorbidities, immune suppression, ex-prem baby
Aged > 65 and 2 of the following, or >80 and one of the following – hospital admission within the last 12 months, DM, CCF, glucocorticoid use
Pneumonia, mastoiditis, peritonsillar abscess, cellulitis
Which antibiotics should be used for otitis media?
Amoxicillin
500mg TDS for 5 days
Which antibiotics are used for sinusitis?
Amoxicillin
Or doxycycline
Which antibiotics should be used for tonsillitis?
Penicillin V for 10 days
Which antibiotics should be used for LRTI?
Amoxicillin
Which Abx should be used for a UTI?
Trimethoprim – 200mg BD for 3 days
OR nitrofurantoin – 50mg QDS for 3 days
Define public health
The science and art of preventing disease, prolonging life and promoting health through organised efforts of society
What are the 3 domains of public health?
Health improvement
Health protection
Improving services
What are the key concerns of public health?
Inequalities in health
Wider determinants of health
Prevention
What is the domain of health improvement concerned with?
Societal interventions:
Inequalities
Education
Housing
Employment
Lifestyles
Family/community
Surveillance and monitoring of specific diseases and risk factors
What is the public health domain of health protection concerned with?
Measures to control infectious disease risks and environmental hazards:
Infectious diseases
Chemicals and poisons
Radiation
Emergency repsonse
Environmental health hazards
What is the public health domain of improving services concerned with?
Organisation and delivery of safe, high quality services for prevention, treatment and care:
Clinical effectiveness
Efficiency
Service planning
Audit and evaluation
Clinical governance
Equity
How can health interventions be applied?
Delivered at an individual level (i.e. vaccinations to prevent an individual from getting ill)
Delivered at a community level (i.e. opening a new outdoor play area in a particular town)
Delivered at a population level (i.e. putting iodine in salt to prevent iodine deficiency)
What needs to be done/performed before a health intervention is made?
A health needs assessment
What is a health needs assessment?
A systematic method for reviewing the health issues facing a population
Leading to agreed priorities and resource allocation that will improve health and reduce inequalities
What are the 3 different approaches of health needs assessments?
Epidemiological
Comparative
Corporate
Define need
Ability to benefit from an intervention
Define demand
What people ask for
Define supply
What is provided
What is a health need and how is it measured?
A need for health
Measured using - mortality, morbidity, socio-demographic measures
What is a health care need?
A need for healthcare – the ability to benefit from health care
Depends on the potential of prevention, treatment and care services to remedy health problems
What are the 4 sociological perspectives of need?
Felt need – individual perceptions of variation from normal health
Expressed need – individual seeks help to overcome variation in normal health (demand)
Normative need – professional defines intervention appropriate for the expressed need
Comparative need - comparison between severity, range of interventions and cost
What does an epidemiological approach to a health needs assessment involve?
Define problem
Look at the size of the problem – incidence/prevelance
Services available – prevention/treatment/care
Evidence base – effectiveness and cost-effectiveness
Models of care – including quality and outcome measures
Existing services – unmet need; services not needed
Recommendations
What are some potential sources of data for an epidemiological HNA?
Disease registry
Hospital admissions
GP databases
Mortality data
Primary data collection (e.g. postal/patient survey)
What are the advantages of an epidemiological HNA?
Uses existing data
Provides data on disease incidence/mortality/morbidity etc.
Can evaluate services by trends over time
What are the disadvantages of an epidemiological HNA?
Quality of data variable
Data collected may not be the data required
Does not consider the felt needs or opinions/experiences of the people affected
What does a comparative approach to a health needs assessment involve?
Compares the services received by a population (or subgroup) with others:
Spacial
Social (age, gender, class, ethnicity)
i.e. COMPARES THE SERVICES FOR A PARTICULAR HEALTH ISSUE IN TWO DIFFERENT AREAS
What factors might a comparative HNA examine?
Health status
Service provision
Service utilisation
Health outcomes (mortality, morbidity, quality of life, patient satisfaction)
What are the advantages of a comparative HNA?
Quick and cheap if data available
Indicates whether health or services provision is better/worse than comparable areas (gives a measure of relative performance)
What are the disadvantages of a comparative HNA?
May be difficult to find comparable population
Data may not be available/high quality
May not yeild what the most appropriate level (e.g. of provision or utilisation) should be
What does the corporate approach to a health needs assessment involve?
Ask the local population what their health needs are
Uses focus groups, interviews, public meetings etc.
Wide variety of stakeholders e.g. teachers, healthcare professionals, social workers, charity workers, local businesses, council workers, politicians
What are the advantages of a corporate HNA?
Based on the felt and expressed needs of the population in question
Recognises the detailed knowledge and experience of those working with the population
Takes into account wide range of views
What are the disadvantages of a corporate HNA?
Difficult to distinguish “need” from “demand”
Groups may have invested interests
May be influenced by political agendas
Define primary prevention and give an example
Preventing disease before it has happened
Examples – change4life, 5 a day
Define secondary prevention and give an example
Catching a disease in its early or pre-clinical phase
Example – breast screening programme (and all screening)
Define tertiary prevention and give an example
Preventing complications of a disease
Example – diabetic foot care, reviews for eyes in diabetic patients, attending physio/rehab after a stroke to prevent immobility and aspiration pneumonia
What are the 2 general approaches to prevention?
Population approach – preventative measures e.g. dietary salt reduction through legislation to reduce BP, adding iodine to salt to prevent iodine deficiency
High risk approach – identifying individuals above a chosen cut-off and treat e.g. screening for hypertension,
What is meant by the prevention paradox?
A preventative measure which brings much benefit to the population often offers little to each participating individual
i.e. it’s about screening a large number of people to help a small number of people
What is screening?
A process which picks out apparently well people who are at risk of a disease, in the hope of catching the disease at its early stage
NOT a diagnostic process – simply a means of assessing risk and catching diseases in their early stage
What are the Wilson and Junger criteria needed for a screening programme?
The disease must be an important problem
The disease must have a known and detectable latent phase
The disease must have a known natural course/progression
There must be a test which is acceptable to the population
There must be a treatment for the disease
There must be an agreed at-risk population of which to screen
There must be an agreed policy on who to treat
The costs of the screening should be economically balanced
What are the different types of screening?
Population-based screening programmes (e.g. cervical cancer, breast cancer)
Opportunistic screening (e.g. performing BP measurements in GP)
Screening for communicable disease
Pre-employment and occupational medicals
Commercially provided screening (where you can pay to get your blood sent off and tested for all sorts of genetic problems)
Genetic counselling (i.e. genetic testing for people with FHx of genetic disease)
What are some disadvantages of screening?
Exposure of well individuals to distressing or harmful diagnostic tests
Detection and treatment of sub-clinical disease that would never have caused any problems
Preventative interventions that may cause harm to the individual or population
What is the sensitivity of a screening test and how do you calculate it?
The proportion of people with the disease who are correctly identified by the screening test
True positive / (true positive + false negative)
What is the specificity of screening and how is it calculated?
The proportion of people without the disease that are correctly excluded by the screening test
True negative / (true negative + false positive)
What is the positive predicted value and how is it calculated?
The proportion of people with a positive test result who actually have the disease
True positive / (true positive + false positive)
What is the negative predictive value and how is it calculated?
The proportion of people with a negative test result who do not have the disease
True negative / (true negative + false negative)
This is lower if the prevalence is higher
Define incidence?
The number of new cases of a disease in a population (e.g. per 100,000) in a given time frame (e.g. per year)
Define prevalence
The total number of people with a condition per 100,000 per year
Number of existing cases/population/point in time
What is meant by lead time bias?
When screening identifies an outcome earlier than it would otherwise have been identified
This results in an apparent increase in survival time, even if screening has no effect on outcome
What is meant by length time bias?
A type of bias resulting from differences in the length of time taken for a condition to progress to severe effects that may affect the apparent efficacy of a screening method
What does a descriptive study design involve?
Case reports or case series – study individuals
Ecological studies – use routinely collected data to show trends in data and thus is useful for generating hypotheses. Shows prevalence and association, cannot show causation
What does a descriptive and analytical study design involve?
Cross section study/survey
Divides populations into those without the disease and those with the disease and collects data on them once at a defined time to find associations at that point in time
They are used to generate hypotheses but are prone to bias and have no time reference
What are the advantages of cross sectional study?
Relatively cheap and quick
Provide data on prevalence at a single point in time
Large sample size
Good for surveillance and public health planning
What are the disadvantages of a cross sectional study?
Risk of reverse causality (don’t know whether outcome or exposure came first)
Cannot measure incidence (number of new cases)
Risk recall bias and non-response
What is a case control study?
A type of analytical study
Retrospective
Takes people with a disease and matches them to people without the disease for age/sex/habitat/class etc
Study previous exposure to the agent in question
Quick and inexpensive
But retrospective nature shows only an association and data may not be reliable due to problems with patients’ memories
What are the advantages of a case-control study?
Good for rare outcomes (e.g. cancer)
Quicker than cohort of intervention studies (as the outcome has already happened – it’s retrospective)
Can investigate multiple exposures
What are the disadvantages of case-control studies?
Difficulties finding controls to match with cases
Prone to selection and information bias
What is a cohort study?
Prospective
Start with a population without the disease in question and study them over time to see if they are exposed to the agent in question and if they develop the disease in question or not
What are the advantages of a cohort study?
Possible to distinguish preceding causes from concurrent associated factors
Lower chance of selection and recall bias
Absolute, relative and attributable risks can be determined
Prospective - so can show causation where retrospective can’t
Good for common and multiple outcomes
What are the disadvantages of a cohort study?
Requires a control group to establish causation
Takes a long time
Loss to follow-up (people drop out)
Need a large sample size
What is a randomised control trial?
Patients are randomised into groups, one group is given an intervention and the other is given a placebo/control and the outcome is measured
Randomisation allows confounding factors to be equally distributed
Confounding and biases are minimalised
Lage, expensive, volunteer bias
Ethical issues – is it ethical to withhold a treatment that is strongly believed to be effective
Shows causation
What are the advantages of a RCT?
Low risk of bias and confounding
Can infer causality (gold standard)
What are the disadvantages of an RCT?
Time consuming
Expensive
Specific inclusion/exclusion criteria may mean the study population is different from typical patients (e.g. excluding very elderly people)
What are is the main issue with a controlled trial that is not randomised?
Very subject to bias
Confounding factors are not equally spread across the groups
What is an independent variable?
A variable that can be altered in a study
What is a dependant variable?
A variable that is dependant on the independant variables, or one that cannot be altered
What is meant by “odds” of an event and how is it calculated?
The odds of an event is the ratio of the probability of an occurrence compared to the probability of a non-occurrence
Odds = probability/ (1 – probability)
What is meant by odds ratio and how is it calculated?
The odds ratio is the ratio of offs for the exposed group to the odds for the non exposed groups
(P exposed/ (1- P exoposed)) / (P unexposed/ (1 – P unexposed))
Or can be interpreted as a relative risk when the event is rare
For case control studies it’s not possible to calcuate the relative risk, so the odds ratio is used
For X-sectional and cohort studies – both can be derived but odds ratio is used if it’s not clear which is the IV and which is the DV
What is meant by epidemiology?
The study of frequency, distribution and determinants of disease and health related states in populations in order to prevent and control disease
Usual factors when measuring epidemiology of a disease – time, place, person (age, gender, class, ethnicity)
What is meant by person time?
Measure of time at risk i.e. time from entry to a study to
i) disease onset
Ii) loss to follow-up
Iii) end of study
Used to calculate incidence rate which uses person time as the denominator
Define incidence rate
Incidence rate = Number of persons who have become cases in a given time period / total person-time at risk during that period
What is meant by absolute risk?
Gives a feel for the actual numbers involved i.e. has units (e.g. 50 deaths/ 1000 population)
What is meant by attributable risk and how is it calculated?
The rate of disease in the exposed that may be attributed to the exposure
Attributable risk = incidence in exposed – incidence in unexposed
It’s about the size of the effect in absolute terms – gives a feel for the public health impact if causality is assumed
What is meant by relative risk and how is it calculated?
Ratio of risk of disease in the exposed to the risk in the unexposed
Relative risk = incidence in exposed / incidence in unexposed
Tells us about the strength of association between a risk factor and a disease
What is relative risk reduction and how is it calculated?
The reduction in rate of the outcome in the intervention group relative to the control group
(incidence in non exposed – incidence in exposed) / incidence in non-exposed
What is absolute risk reduction and how is it calculated?
The absolute difference in the rates of events between the 2 groups
Gives an indication of the baseline risk and the intervention effect
Incidence in non-exposed – incidence in exposed
i.e. assuming exposed means they have had a particular intervention (such as giving statins to people with hypercholesterolaemia and then a control group who do not have statins and seeing how many in each group have a heart atttack to see if the intervention of statins is effective
What is meant by number needed to treat and how is it calculated?
NNT = the number of patients we need to treat to prevent one bad outcome
NNT = 1/(risk in non-exposed – risk in exposed)
Aka 1/absolute risk reduction
What are the 5 factors that could be responsible if a study finds an association between an exposure and an outcome?
Bias
Chance
Confounding factors
Reverse causality (i.e. the one thing is actually causing the other)
A true causal association
Define bias
A systematic deviation from the true estimation of the association between exposure and outcome
What are the 3 main types of bias?
Selection bias
Information (measurement) bias
Publication bias
What is a selection bias?
A systematic error either in the selection of study participants or the allocation of participants to different study groups
E.g. non-response, loss to follow up, those in the intervention group different in some way from the controls other than the exposure in question
What is an information/measurement bias?
A systematic error in the measurement or classification of the exposure or outcome
What are some potential sources of information/measurement bias?
Observer bias
Participant – recall bias, reporting bias
Instrument – a wrongly calibrated instrument
What is meant by confounding?
A situation in which the estimate of association between an exposure and outcome is distorted because of the association of the exposure with another factor (confounder) that is also independently associated with the outcome
What is meant by reverse causality?
This refers to a situation when an association between an exposure and an outcome could be due to the outcome causing the exposure rather than the exposure causing the outcome
What are the Bradford-Hill criteria for causality?
Strength of association – the magnitude of the relative risk
Dose-response – the higher the exposure, the higher the risk of disease
Consistency – similar results from different researchers using various study designs
Temporality – does exposure precede the outcome
Reversibility (experiment) – removal of the exposure reduces the risk of disease
Biological plausibility – biological mechanisms explain the link
Coherence – logical consistency with other information
Analogy – similarity with other established cause-effect relationships
Specificity – relationship specific to outcome of interest
Define addiction
Craving, tolerance, compulsive drug/substance seeking behaviour, physiological withdrawal state
What are the 3 main effects of dependant drug use?
Physical
Social
Psychological
Describe some physical effects of dependant drug use
ACUTE:
Complications of injecting (DVT, abscesses, SBE – subacute bacterial endocarditis)
Overdose (respiratory depression)
Poor pregnancy outcome
Side effects of opiates – constipation, dry mouth
CHRONIC:
Blood-borne virus transmission
Effects of poverty (e.g. spending money on drugs so not being able to afford food)
Side effects of cocaine (vasoconstriction, local anaesthesia)
Describe some social effects of drug use
Effects on families
Drive to criminality
Imprisonment
Social exclusion
Describe some psychological effects of drug use
Fear of withdrawal
Craving
Guilt
Depression
Pre-occupation with finding the next load of the drug can lead to anxiety and low mood
How often must heroin be used in people with heroin dependency to avoid withdrawal?
8 hourly
What are the effects of heroin?
Eurphoria
Intense relaxation
Miosis
Drowsiness
What are the adverse effects of heroin?
Dependence
Withdrawal symptoms
Nausea
Itching
Sweating
Constipation
Overdose 🡪 respiratory depression and death
What can be offered in primary care to a newly presenting drug user?
Health check
Screening for blood borne viruses and referral if positive result
Contraception, smear
Sexual health advice
Check general immunisation status and hep A/B
Signpost to additional help – counselling, benefits, housing
Information on local drug services – including needle exchange
What is some harm reduction advice you can give to a drug user?
Not injecting or safe injecting (don’t share needles, use a new one each time)
Not mixing respiratory depressants
Not using drugs alone
Reducing amount taken after intervals where tolerance is lost
Call an ambulance if necessary
Safe sex
Information about blood borne viruses
Where can you refer someone with a drug problem?
Specialist drug services
Voluntary sector services
Infectious disease services
In which groups of patients is detoxification more likely to work?
Younger users
Less time addicted
Lower level of drug use