Psychosis and schizophrenia Flashcards
1) What happens in psychosis?
2) Define hallucination.
3) Define delusion.
4) What is the lifetime risk of developing schizophrenia?
5) When is the usual onset of schizophrenia?
1) People lose touch with reality, experiencing hallucinations and delusions.
2) A perception in the absence of a stimulus.
3) A fixed, false belief held despite rational argument or evidence to the contrary. It cannot be explained by the patient’s cultural, religious or educational background.
4) About 1%.
5) Onset is typical from 15 to 45 years.
1) Who is affected more by schizophrenia?
2) When schizophrenia presents in childhood, what is it often associated with?
3) Describe the aetiology of schizophrenia.
4) What is the lifetime risk of schizophrenia for first degree relatives of people with schizophrenia.
5) What is the lifetime risk of schizophrenia for a child whose parents are both affected by schizophrenia?
1) Overall men and women are affected equally, but men tend to be affected earlier and more severely than women.
2) When it presents in childhood, it is often associated with developmental delay.
3) There is a complex, multifactorial aetiology.
4) Lifetime risk increases from 1-10% for 1st degree relatives of people with schizophrenia
5) 48%.
Name 6 potential aetiologies for schizophrenia or psychosis.
1) Genetics
2) Obstetric complications
3) Substance misuse
4) Social disadvantage
5) Urban life and birth
6) Migration and ethnicity
7) Expressed emotion
8) Premorbid personality
9) Adverse life experience
1) What is the monozygotic twin concordance rate for schizophrenia?
2) What is the dizygotic twin concordance rate for schizophrenia?
3) What do adoption studies show for aetiology of schizophrenia?
4) Briefly describe the proposed genetic basis behind the development of schizophrenia.
5) What is it thought that genes code for in schizophrenia?
6) Name 3 symptom clusters.
1) 40-50%
2) 10-20%
3) They show that children of people with schizophrenia, raised in families without schizophrenia, remain at high risk of the disorder.
4) It is thought that multiple susceptibility genes probably interact, each making someone slightly more likely to develop schizophrenia.
5) It is thought that genes code for symptom clusters, creating an overlap between genes that contribute to a spectrum os psychotic disorders (schizophrenia, schizoaffective psychosis and affective psychosis).
6) Psychotic, depressive and manic symptoms.
1) What 5 obstetric complications could contribute towards an increased risk of developing schizophrenia?
2) With regards to obstetrics, when are rates of schizophrenia found to be higher?
3) What underlying abnormalities might be reflected by obstetric complications which can lead to schizophrenia?
4) Name 4 substances which can cause psychotic symptoms.
5) Describe how cannabis can relate to the development of schizophrenia.
1) Prenatal malnutrition, viral infections, pre-eclampsia, low birth weight and emergency Caesarean section.
2) Rates of schizophrenia are higher in people born in the winter (Jan-Mar in the Northern hemisphere), when viral infections are rife.
3) Underlying genetic abnormalities or hypoxic brain damage.
4) Cananbis, amphetamines, cocaine and LSD.
5) Cannabis does not cause schizophrenia in itself, but it increases the overall risk, contributing to the development of the disorder in susceptible people.
1) Name the enzyme which breaks down Dopamine.
2) Name the 2 alleles which code for the enzyme that breaks down dopamine.
3) Describe the relationships between these alleles and the risk of schizophrenia.
4) Which type of cannabis is particularly dangerous for those vulnerable to schizophrenia?
5) Why is this type of cannabis particularly dangerous?
1) Catechol-O-methyl transferase (COMT) breaks down Dopamine.
2) Val and Met code for COMT.
3) The val allele increases the risk of schizophrenia in cannabis users. People who are val-val have the highest risk.
4) Skunk.
5) Because it has higher concentrations of tetrahydrocannabinol, which is the chemical in cannabis most associated with psychosis.
1) Why are adolescents very vulnerable to developing psychosis after smoking cannabis?
2) Which social class is schizophrenia more prevalent in?
3) Describe the downward drift of social class with regards to schizophrenia.
4) Why might schizophrenia be twice as prevalent in urban than rural areas?
5) With regards to migration and ethnicity, who has a higher risk of developing schizophrenia?
1) Because their brains are still developing.
2) Higher prevalence of schizophrenia amongst adults of lower SES.
3) People who have schizophrenia with a lower SES did not necessarily start with a lower SES. Therefore, the downward drift is thought to be due to the illness, and the lower SES results from social isolation and unemployment.
4) Due to downward drift or due to stress that is specific to the urban environment.
5) First and second generation immigrants have an average 3 fold increase in risk of schizophrenia. Black Caribbean and black African populations have a 4-6 fold increase in risk of schizophrenia compared to white British populations.
1) What can double the risk of relapse in patients with schizophrenia in the 9-18 months following discharge from hospital.
2) What type of premorbid personality precedes schizophrenia in up to a quarter of cases?
3) Name the disorder which is more commonly associated with schizophrenia and state why.
4) What adverse life experiences increase the risk of schizophrenia?
1) Close contact with highly critical or over involved relatives doubles the rate fo relapse in the 9-18 months following discharge from hospital.
2) Schizoid personality precedes schizophrenia in up to a quarter of cases.
3) Schizotypal disorder is commonly associated, possibly due to a shared genetic basis.
4) Sexual or physical abuse in childhood or adulthood increase the risk of schizophrenia.
1) Name the 3 main theories of development of schizophrenia.
2) State the 2 macroscopic changes to the brain which have been identified in patients with schizophrenia.
3) What part of the neurodevelopmental theory suggests that changes in the brain that can lead to schizophrenia occur before adulthood?
4) Which 4 psychological factors might cause brain changes which can lead to contribute to the development of schizophrenia.
5) Describe how initial brain abnormalities may progress to evolve to cause overt schizophrenic symptoms.
1) Neurodevelopmental theories, neurotransmitter theories and psychological theories.
2) Enlarged ventricles and overall smaller and lighter brains.
3) There is no gliosis at post mortem.
4) Lower pre-morbid IQ, deficits in learning, memory and executive function.
5) These abnormalities progress as the brain matures through ongoing myelination and synaptic pruning. Maturation with other risk factors such as cannabis may allow functional and connectivity abnormalities to evolve until overt schizophrenic symptoms emerge.
Describe the 2 psychological theories behind the development of schizophrenia.
1) Cognitive models propose subtle defects of thinking such as tendency to jump to conclusions without adequately examining contraindicatory evidence, leading to delusions.
2) Fear of madness may prompt the defences of denial and rationalisation, resulting in a delusional system to explain persecutory voices.
1) What does the Dopamine hypothesis state?
2) What are positive symptoms thought to result from?
3) What are negative symptoms thought to arise from?
4) Why is it thought that Dopamine is not the only causative neurotransmitter?
5) What other 2 neurotransmitters might be implicated in the aetiology of schizophrenia?
1) That schizophrenia is a result of dopamine overactivity in certain areas of the brain.
2) Excess dopamine in the mesolimbic tracts.
3) Dopamine underactivity in the mesocortical tracts.
4) Because antipsychotics which target dopamine do not cure all psychoses.
5) Serotonin overactivity and Glutamate dysregulation.
1) Give the 3 clinical stages that schizophrenia can be divided into.
2) Why is the term prodrome losing popularity?
3) What is the typical picture of someone at the ‘at risk mental state’ stage.
4) What does a patient in the ‘at risk mental state’ seem like?
5) What 3 other conditions can the ‘at risk mental state’ be hard to distinguish from?
1) At risk mental state (prodrome), acute phase, chronic phase.
2) Because it wrongly suggests that psychosis is inevitable.
3) Someone in their late teens or early twenties who has dropped out of college or work after a period of increasing absences.
4) They often seem ‘distant’, giving no reason for self-isolation.
5) depression, substance misuse and normal teenage behaviour.
State 5 of the low grade symptoms associated with the ‘at risk mental state’.
1) Social withdrawal
2) Loss of interest in:
a) work
b) study
c) relationships
3) No psychotic symptoms
1) What does the acute phase of psychosis have?
2) What does disturbed thinking in the acute phase of psychosis cause?
3) What 3 negative symptoms can also be present in the acute phase?
4) What type of delusions are most often present in schizophrenia/ psychosis?
1) The most striking and florid psychotic features (hallucinations and delusions) - consists of positive symptoms.
2) Muddled speech and withdrawn, overactive or bizarre behaviour.
3) Marked decrease in self care, social withdrawal and anhedonia can also present in the acute phase.
4) Persecutory.
State the 5 first rank symptoms of schizophrenia.
1) Delusional perceptions
2) Passivity
3) Delusions of thought interference.
4) Third person auditory hallucinations.
5) Thought echo.
1) What is a delusional perception?
2) What is passivity?
3) What is thought interference?
4) What are the 3 types of thought interference?
5) What is formal thought disorder?
6) What are the 2 types of third person auditory hallucinations?
1) A 2 stage process whereby a real perception is interpreted in a delusional way (The traffic light turned to green and I knew I was the Queen of Ireland).
2) The belief that movement, sensation, emotion or impulse are controlled by an outside force.
3) When the patient believes that their thoughts are under the control of something or someone else.
4) Thought withdrawal, thought insertion and thought broadcasting.
5) When thoughts become disconnected (loosening of associations).
6) Running commentary and two voices conversing.
Name 5 other symptoms of schizophrenia which are not 1st rank symptoms.
1) World salad
2) Poverty of thought
3) Thought blocking
4) Disjointed speech (circumstantial speech)
5) 1st and 2nd person auditory hallucinations.
1) What might happen to some patients’ psychoses after a few years?
2) Rather than becoming well, what might happen to a patient after the acute phase?
3) How long might the chronic phase last?
4) How might negative symptoms of the chronic phase manifest?
5) How might positive symptoms still manifest in the chronic phase?
1) Some patients’ psychoses may become ‘burnt out’ after a few years.
2) They could enter a chronic phase.
3) May last indefinitely and can be immensely disabling.
4) As a lack of attention to personal hygiene and care, a limited repertoire of daily activities and social isolation.
5) There may be residual and less prominent positive symptoms (a person may still have persecutory delusional thoughts, bu seem less distressed and affected by them).
Name 5 negative symptoms of the chronic phase.
1) Apathy: opposite of enthusiasm, loss of motivation.
2) Blunted affect: decreased reactivity of mood.
3) Anhedonia: inability to enjoy interests/ activities
4) Social withdrawal
5) Poverty of thought and speech
1) What 2 conditions can both resemble the chronic phase?
2) What can schizophrenia presentations be divided into?
3) What are the 5 subtypes of schizophrenia?
4) What is the most common subtype of schizophrenia?
5) What is paranoid schizophrenia exemplified by and what are the main symptoms?
1) Depression and antipsychotic side effects, but they are often much easier to treat.
2) Different subtypes based upon the most prominent symptoms.
3) Paranoid, catatonic, hebephrenic, simple and residual.
4) Paranoid.
5) Exemplified by the acute phase of schizophrenia description and the main symptoms are prominent delusions and hallucinations.
1) What is catatonic schizophrenia dominated by?
2) What is stupor?
3) What is excitement?
4) What is posturing?
5) What is rigidity?
1) Psychomotor disturbance.
2) A state of being immobile, mute and unresponsive, despite appearing to be conscious (eyes are open and will follow people around the room).
3) Periods of extreme and apparently purposeless motor hyperactivity.
4) Assuming and maintaining inappropriate or bizarre positions.
5) Holding a rigid posture against efforts to be moved.