Psychosis Flashcards

0
Q

Symptoms of psychosis

A
Hallucination:visual, auditory 
Delusion
Agitation /pacing 
Mood change 
Disjointed thoughts 
Self-care decline (negative symptoms)
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1
Q

Psychosis

A

General term which refers to a cluster of symptoms that involve major distortions in how people perceive and interpret

-delusion and hallucination =major disturbance in thinking, feeling, and behaviour

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2
Q

Delusion

A

Belief

  • usually false,very pre-occupying, subjectively important
  • held for reason that are difficult to make sense of
  • usually directly relevant to the person experiencing it

Not -understandable in the context of the person’s religion, culture
-amenable to challenge or counter-argument

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3
Q

Hallucination

A

Vivid perception without an external stimulus when no actual stimulus

Often auditory, or visual-can also be touch, smell,taste

Normal in some situations (bereavement,when falling asleep)

Not- easily distinguished from “real” perception in internal space

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4
Q

Psychotic disorder that are not related to mood disorder or organic factor

A

Schizophrenia
Delusional disorder
Acute and transient psychotic disorder
– isolated episode of psychosis might be due to stress

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5
Q

Psychotic disorder related to mood

A

Mania or depression with psychotic symptoms (bipolar)

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6
Q

Psychotic disorder relayed to organic factor

A

Street drug, medicine (steroid), confusional states, dementia, neurological/endocrine illness

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7
Q

Schizophrenia

A

Before onset

  • emotionally and socially detached, solitary
  • mild cognitive, emotional, motor problems in childhood

Prodrome (before develop acute symptom) -前兆

  • median 2-3 years
  • insidious loss of motivation, social withdrawal,decline in performance
  • attenuated psychotic symptoms; misperceptions, illusions, unusual ideas

These features do not occur in everybody

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8
Q

Acute/Positive Symptoms of schizophrenia

A
  • hallucination; any sense (esp,auditory)
  • delusion; any content
  • passivity experience; boundary b/w self and outside world breaks down
  • –ie, your thoughts are taken away by some external agent, broadcast your thoughts out
  • thought disorder; incoherence of thought and speech with drifting b/w topics that doesn’t make sense of
  • disorganized behaviour, deterioration in social functioning and self-care,distress
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9
Q

Negative symptoms of schizophrenia

A
  • loss of drive and determination
  • loss of interest in other people and capacity for forming relationship
  • loss of emotional reactivity
  • paucity of speech and loss of interest
  • often the most disabling aspects of illness, even though much less dramatic than positive symptoms
  • have an environmental component-ie,unstimulating environment
  • accompanied by minor deficits in cognitive functioning, fall in IQ already present by onset of illness
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10
Q

Symptom pictures that esp suggest schizophrenia

A
  • positive symptoms for at least a month (6month in us)
  • passivity experience or voice talking in 3rd person
  • affect doesn’t fit with content of speech-incongruous or flat affect
  • > ie, laughing when talking about their pets death
  • psychotic symptoms are not obviously mood-related
  • content of delusions is bizzar or impossible
  • hallucinations are very persistent
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11
Q

Bipolar affective disorder /manic depressive illness

A
  • Episodes of both depression and of elevated mood
  • most people who have manic episodes also have depressive ones
  • bipolar spectrum including milder undiagnosed presentation. (Bipolar ||)

Onset: median age of early 20s

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12
Q

Impact of schizophrenia

A

1% of population, one of the top ten cause of disability

High rate of suicide (10-15%)

Drug and alcohol abuse

Cardiovascular disease

12-15years reduction in life expectancy

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13
Q

Prognosis of schizophrenia

A

10-20% one episode only

1/3 -deteriorating court with poor recovery between episodes including negative symptoms

2/3- recurrent episode but good recovery in between

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14
Q

Better prognosis of schizophrenia with

A

Acute onset (without prodrome), esp response to stress

Family history of affective disorder, not schizophrenia

Good premorbid functioning
Later onset , female

No substance misuse

Not in high expressed emotion environment

Developing country

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15
Q

Neuro chemistry evidence of schizophrenia

A

Dopamine theory

Overactive of dopamine
Drug reducing dopamine reduce psychosis
Imaging shows the evidence of over activity in mesolimbic dopamine (D2) pathway; reward motivation area

16
Q

Structural evidence of schizophrenia

A

Reduction in brain volume overall, including progressive thinning of cortex

Abnormal connection in white matter may pre-date illness many years

17
Q

Epidemiological finding of risk of schizophrenia

A

Men- affected earlier and more severe

Risk factor

  • cannabis use esp early adolescence
  • social deprivation
  • urban environment
  • migrant background, esp black Caribbean
  • trauma
18
Q

Course of bipolar affective disorder

A
  1. Euthymia (normal mood)
  2. Hypomania
  3. Mania
  4. Mania + psychotic symptom (2/3 people with mania)
19
Q

Hypomania

A

Persistent elevated mood
Increased energy, activity, sociability, feeling of wellbeing
Disinhibition, increased libido
Decreased sleep, concentration
Talkative & speech pressured
Perception more vivid, mild overspending

Depression +hypomania = bipolar II

20
Q

Mania

A
Speech-uninterruptible 
Flight of idea-Jump topics rapidly 
Very disrupted sleep 
Restless +agitation 
Loss of inhibition and impulse control 
Disregard of risk 
Irritability and aggression, occasionally violence 

1 week of duration: complete disruption of work + social life

21
Q

Frequency of psychosis

A

New case of psychosis( incidence)
-20-30 new case per year (5-15 schizophrenia)

Lifetime risk of psychosis
-1.5-3 % (0.5-1.5-% schizophrenia )

22
Q

Contributory psychosocial factors for bipolar

A
  • strong negative and positive beliefs about the self, world, others
  • extreme positive and negative interpretation of change to mood
  • unstable self esteem
  • poor coping style
  • over sensitive to disruption to routine and sleep patterns
  • over sensitivity to reward and achieving goal
  • poor social support
  • positive and negative life events, such as childhood trauma
23
Q

Epidemiology of bipolar

A

1% prevalence diagnosed
“Bipolar spectrum” including milder undiagnosed presentation (bipolar II) -up to 5-6%

Onset -median 20s

Most people recover but 10-20% remain significantly unwell

24
Q

Prognosis of bipolar

A

Much more time in depression than manic episode (20% vs 5%)

Suicide risk in depression

Increase depression than mania as get older

Worse prognosis with

  • early onset
  • comorbid substance abuse, anxiety, personality disorder
25
Q

Service for management of psychosis

A

First onset & acute relapse
Acute inpatient wards
Crisis & home treatment team

Early intervention service

Continuing care -first 3 years
Supporter housing, day and vocational service, welfare service

Continuing care- after first 3 years
Assertive outreach teams 
Rehabilitation service 
Community mental health team 
Primary care
26
Q

Antipsychotic medication

A

In acute relapse of schizophrenia
-75% recover with antipsychotic vs 25% without

  • most improvement in first 6 weeks
  • 55% relapse without antipsychotic vs 14-24% with it

No/limited effect in negative symptoms

27
Q

Side effect of antipsychotic

A
Weight gain 
Metabolic syndrome 
Motor side effect -repetitive movement 
Sedation 
Raised prolactin 
Cardiac arrhythmias 
Neuroleptic malignant syndrome
28
Q

Common comorbid disorder in psychosis

A

Depression
Anxiety
Substance abuse
PTSD

29
Q

High expressed emotion

A

Critical comments and emotional over-involvement

30
Q

Risk factor for bipolar

A

Genetic
-67% risk for twins
15-20% for children of a parent with bipolar disorder

Life event-triggers for individual episode

Can begin after child birth

Organic mania- especially if late onset (hormone, drugs)

Some psychological risk factor
-black/white thinking