Psychosis Flashcards
What is the neurotransmitter involved in all psychosis?
Dopamine
What do treatments for psychosis aim to do?
Lower dopamine levels in the CNS.
May induce parkinsonism due to lowered DA all around.
Increased activity in the nigrostriatal tract is thought to be related to what sign in schizophrenia?
Neurocognitive deficits - looks like dementia
Memory, conc., attention, speech (Thought process) all affected.
Increased DA activity in the mesolimbic tract are associated with which signs of schizophrenia?
Positive symptoms.
Delusions
Hallucinations
Disorganized speech - looseness of assocation, flight of ideas
Disorganized or catatonic behavior - psychomotor agitation
Decreased DA activity in the mesocortical tract is associated with which signs of schizophrenia?
Negative symptoms.
Apathy Alogia (poverty of speech) Affective flattening Anhedonia Attention deficit
Why do we see hyperprolactinemia with anti-psychotic treatments?
Dopamine acts to suppress PRL release from the tuberoinfundibular tract. Anti-psychotics lower DA levels.
What is a delusional perception?
Normal perception of reality but has a delusional idea about it and acts on that idea. Prone to violence.
What is somatic passivity?
One believes that they are recipients of bodily sensations imposed from outside.
What is thought insertion?
Belief that thoughts are being put into mind by outside force.
What is thought withdrawal?
Belief that thoughts are being stolen from them
What is thought broadcasting?
Belief that their thoughts are transmitted to others.
What is the defense mechanism most employed in schizophrenia?
Projection
What is the stress-diathesis model?
Somebody gets d/o by having a genetic predisposition to the d/o and the onset is caused by some environmental stress.
What is the diagnostic criteria for schizophrenia?
> 6 mos. of positive symptom and negative symptoms.
What is the diagnostic criteria for schizophreniform d/o?
1-6 mos. of positive symptoms and neg. symptoms.