Psychosis Flashcards

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1
Q

What is the neurotransmitter involved in all psychosis?

A

Dopamine

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2
Q

What do treatments for psychosis aim to do?

A

Lower dopamine levels in the CNS.

May induce parkinsonism due to lowered DA all around.

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3
Q

Increased activity in the nigrostriatal tract is thought to be related to what sign in schizophrenia?

A

Neurocognitive deficits - looks like dementia

Memory, conc., attention, speech (Thought process) all affected.

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4
Q

Increased DA activity in the mesolimbic tract are associated with which signs of schizophrenia?

A

Positive symptoms.

Delusions
Hallucinations
Disorganized speech - looseness of assocation, flight of ideas
Disorganized or catatonic behavior - psychomotor agitation

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5
Q

Decreased DA activity in the mesocortical tract is associated with which signs of schizophrenia?

A

Negative symptoms.

Apathy
Alogia (poverty of speech)
Affective flattening
Anhedonia
Attention deficit
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6
Q

Why do we see hyperprolactinemia with anti-psychotic treatments?

A

Dopamine acts to suppress PRL release from the tuberoinfundibular tract. Anti-psychotics lower DA levels.

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7
Q

What is a delusional perception?

A

Normal perception of reality but has a delusional idea about it and acts on that idea. Prone to violence.

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8
Q

What is somatic passivity?

A

One believes that they are recipients of bodily sensations imposed from outside.

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9
Q

What is thought insertion?

A

Belief that thoughts are being put into mind by outside force.

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10
Q

What is thought withdrawal?

A

Belief that thoughts are being stolen from them

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11
Q

What is thought broadcasting?

A

Belief that their thoughts are transmitted to others.

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12
Q

What is the defense mechanism most employed in schizophrenia?

A

Projection

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13
Q

What is the stress-diathesis model?

A

Somebody gets d/o by having a genetic predisposition to the d/o and the onset is caused by some environmental stress.

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14
Q

What is the diagnostic criteria for schizophrenia?

A

> 6 mos. of positive symptom and negative symptoms.

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15
Q

What is the diagnostic criteria for schizophreniform d/o?

A

1-6 mos. of positive symptoms and neg. symptoms.

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16
Q

What is the diagnostic criteria for Brief Psychotic Disorder?

A

Total duration of 1 day - 1 mos.

NO NEGATIVE SYMPTOMS

17
Q

What is the main predictor that newly diagnosed schizophrenia will continue on to become schizophrenia?

A

Presence of negative symptoms.

18
Q

What is schizoaffective disorder?

A

Schizophrenia and mood disorder that are concurrent during the entire duration of the disorder.

Mood can be depressive or manic

19
Q

How can you tell between schizoaffective disorder and a primary mood disorder with psychotic features?

A

A primary mood disorder must have been diagnosed long before the schizophrenia.

20
Q

How can you tell that you have 2 independent diagnoses of schizophrenia and mood disorder?

A

Schizophrenia had been established earlier. Mood disorder has been established later.

21
Q

What sign of autism spectrum disorder must not be confused with schizophrenia?

A

Disorganized behavior

Disorganized speech

22
Q

What is the diagnostic criteria for delusional disorder?

A

1 or more delusions for more than 1 mos.

No prior Hx of schizophrenia

No marked impairment and mood episodes are brief

23
Q

What are the different types of abnormal thoughts?

A

Overvalued idea, preoccupation, rumination, obsession, delusion.

24
Q

What part of the brain is dysfunctional with delusions?

A

Frontal cortex = insight

25
Q

How can marijuana bring about delusional thoughts?

A

Marijuana can stun the frontal cortex and can elevate your preoccupations to a delusion.

If you stun your frontal cortex enough it can become a full blown auditory hallucination.

26
Q

Describe Capgras syndrome.

A

Delusion that a close relative/friend has been replaced by an impostor.

27
Q

Describe Fregoli’s syndrome.

A

Belief that familiar person can change themselves into another person at will.

Intermetamorphosis / shapeshifting

28
Q

Describe Catard Syndrome.

A

Delusional belief of having lost status or possession.

Loss of heart, blood, intestines.
Loss of courage. (Wiz of Oz)

29
Q

What is Catatonia?

A

It is a behavioral disturbance that can be divided into

abnormal motor activity
decreased engagement

30
Q

Severe motor immobility

A

Stupor

31
Q

Moderate motor impairment

A

Catalepsy or obtunded

32
Q

Purposeless act performed within the context of a goal directed behavior

A

Mannerism (baseball player with gloves)

33
Q

Senseless act

A

Stereotypy

34
Q

Not talking at all

A

mutism

35
Q

Less severe version of being mute

A

negativism

36
Q

All substances can induce psychosis besides… (3)

A

Nicotine
Caffeine
Opioids