Psychoses and Antipsychotic Medications Flashcards
What is the MOA of chlorpromazine?
antihistaminic anticholinergic anti dopaminergic anti serotonergic anti noradrenergic
What are the dopamine related drug effects?
euphoria psychomotor agitation dystonia akathisia pseudo parkinsonism hyperprolactinaemia
What are the serotonin related drug effects?
headache, nausea, insomnia, agitation, sexual dysfunction
What are the noradrenaline related drug effects?
postural hypotension sedation anxiety psychomotor agitation euphoria
What are the features of neuroleptic malignant syndrome?
rigidity fever autonomic instability dehydration myonecrosis myoglobinuria tachycardia diaphoresis elevated CK
Which anti psychotic has the highest EPS risk?
haloperidol
Which anti psychotic is the most efficacious?
clozapine
Which antipsychotic causes the most prolactin elevation?
paliperidone
Which antipsychotic lowers prolactin?
aripiprazole
Which antipsychotic causes the least weight gain?
haloperidol
Which antipsychotic causes the most weight gain?
olanzapine
Which antipsychotic causes the least QTc prolongation?
lurasidone
Which antipsychotic causes the most QTc prolongation?
amisulpride
Which antipsychotics are the most sedative?
clozapine, chlorpromazine, quetiapine
