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Psychiatric > Psychopharmacology > Flashcards

Psychopharmacology Flashcards

1
Q

Synaptic cleft

A

Small space between 2 neurons

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2
Q

Presynaptic neurons

A

conduct impulses towards synapse

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3
Q

Postsynaptic neurons

A

conduct impulses away from synapse

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4
Q

Neurotransmitters are the…

A

KEY
- binds to receptor sites on postsynaptic neuron to determine if another impulse will be generated

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5
Q

Agonist

A

Produces a response
- excitatory= key turns

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6
Q

Antagonist

A

Inhibitory= No response
- key sits and take up space

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7
Q

Inactivated

A

degraded / broken down by enzyme

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8
Q

Re-uptake

A

returned to vesicles to be stored and used again ( back to mama )

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9
Q

Re-uptake Inhibitor/ blocker

A

Stops neurotransmitters from being broken down –> more of the neurotransmitters is available in the environment

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10
Q

Re-uptake enhancer

A

Increases breakdown of neurotransmitters

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11
Q

Neurons are the..

A

Door

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12
Q

Receptors is the…

A

Lock
- protein on surface of/ within cell that binds and initiates a change within the cell

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13
Q

Vesicle

A

The mom
- holds neurotransmitters and keep it fresh

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14
Q

Neurotransmitter: ACETYLCHOLINE

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • AcH
    -Cholinergics
  • Controls memory, learning, and big mvt
  • Increased levels= DEPRESSION
  • Decreased levels= ALZHEIMERS
  • Destroyed/inhibited by: Acetylcholesterase
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15
Q

Neurotransmitter: NOREPINEPHRINE

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • N
  • Monoamines
  • Controls: motivation, vigilence, executive function ( attention, concentration, memory, perception, learning, problem solving )
  • Decreased levels: Memory loss, social withdrawal, depression
  • Increased Levels: MANIA, SCHIZOPHRENIA, ANXIETY
  • Destroyed/inhibited by: MAO ( monoamine oxidase)
    COMT ( catechol-o-methyltransferase)
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16
Q

Neurotransmitter: DOPAMINE

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • D or DA
  • Monoamines
  • Controls: Risky (risk taker), Randy (hypersexuality), Reward (brain will seek award)
  • Destroyed/inhibited by: MAO ( monoamine oxidase)
    COMT ( catechol-o-methyltransferase)
17
Q

Neurotransmitter: SEROTONIN

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • S / 5-HT
  • Monoamines
  • Controls: mood, aggression, appetite, libido, sleep, arousal, pain, SI, judgement, coordination
  • Role: in anxiety, mood disorders, schizophrenia
  • Destroyed/inhibited by: MAO ( monoamine oxidase)
18
Q

Neurotransmitter: HISTAMINE

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • H
  • Monoamines
  • Controls: Allergic and inflammation reactions, role in CNS - limited info (wakefulness/ alertness, anti-histamine -> sedation -> sleepy)
  • Destroyed/inhibited by: MAO ( monoamine oxidase)
19
Q

Neurotransmitter: GAMMA-AMINO BUTYRIC ACID

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • GABA
  • Amino Acid
  • Inhibitory: slow down, body -> reduces aggression anxiety
  • Decreased levels= anxiety disorders/ mania-
  • Destroyed/inhibited by: GABA transaminase
20
Q

Neurotransmitter: GLUTAMATE

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • NMDA
  • Amino acid
  • Controls: learning memory
  • Increased levels= alzheimers disease
  • Decreased levels= schizophrenia / psychosis
21
Q

Neurotransmitter: ENDORPHIND AND ENKEPHALINS (opiods)

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • Neuropeptides
  • Alters release of dopamine
  • may link to schizophrenia
22
Q

Neurotransmitter: SUBSTANCE P

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • Neuropeptides
  • Controls: pain/sensory transmission
  • Increased level: Depression
23
Q

Neurotransmitter: SOMATOSTATIN

( Symbol, Categories, What it does?, Destroyed/ inhibited by, Increased/ decreased levels )

A
  • Growth hormone
  • neuropeptides
  • Stim release of: D,S,N,ACH
  • Inhibits release of: N,H, NMDA
24
Q

RI =

A

Re-uptake inhibitor = stops neurotransmitter breakdown

25
Q

RE=

A

Re-uptake enhancer= increases neurotransmitter breakdown

26
Q

SSRI ( med, example, MOA )

A
  • Selective serotonin reuptake inhibitor
  • Ex: Prozac (fluoxetine)
  • MOA: blocks re-uptake of serotonin = more serotonin available in the brain
27
Q

SDA ( med, example, MOA )

A
  • Serotonin Dopamine Antagonist
  • Ex: Seroquel (quetiapine)
  • MOA: the neurotransmitter is going to sit there and take up space
28
Q

SNRI ( med, example, MOA )

A
  • Serotonin Norepinephrine Reuptake Inhibitor
  • Ex: Cymbalta ( venlafxine ), Pristia ( desvenalfaxine )
  • MOA: Will make more S and N available at the synaptic cleft
29
Q

DRI ( med, example, MOA )

A
  • Dopamine Reuptake Inhibitor
  • Ex: Provigil (modafinil )
  • MOA: Will make more D available at the synaptic cleft
30
Q

SPARI ( med, example, MOA )

A
  • Serotonin Partial Agonist Reuptake Inhibitors
  • Ex: Viibryd
  • MOA: 2 jobs in 1

Psychiatric (8 decks)

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