Psychopharmacol

Question 0

Antipsychotics cardiac profile

Answer 0

Ziprasidone - contraindicated
Quetiapine, iloperidone - warning
Olanzapone - maybe safest

Question 1

Centrally acting alpha 2 receptor agonists

Answer 1

Cloned one guanfacine methyl dopa

Can make depressive symptoms worse

Question 2

Weight gain of antipsychotics

Answer 2

CO> QR > AZ

Clozapine olanzapine most
Quet risperidone medium
Aripip ziprasidone lowest

Question 3

Moa of tetrabenazine

Answer 3

For tx of Huntington’s chorea

• depletes monos mine stores from pre synaptic nerve terminals
• 2d6 metabolized so watch for PM and for interactions
• start 12.5mg qday and titrate up weekly by that amount up to 37.5-50mg/day in 2-3 divided doses
• it tx interrupted by 5 days - retitrate

Question 4

Drug that has Stevens Johnson risk

Answer 4

Modafanil and armodafail