Psychopharm Résumé

Question 1

What are CYP1A2 inhibitor?

Answer 1

Luvox, CIPRO, E- , Izoniazide

These substances inhibit the activity of the CYP1A2 enzyme.

Question 2

List some CYP1A2 inducers.

Answer 2

• CBZ
• Primidone
• Barbiturates
• Rifampin
• Cigarette smoke (including cannabis smoke)
• Millepertuis

Inducers increase the activity of the CYP1A2 enzyme.

Question 3

Which medications are substrates of CYP1A2?

Answer 3

• Clozapine
• Olanzapine
• Risperidone
• Mirtazapine
• Theophylline
• Caféine
• Clomipramine
• Triptans
• Coumadin

Substrates are medications that are metabolized by the CYP1A2 enzyme.

Question 4

What should be done if a patient who smokes is taking clozapine?

Answer 4

Increase the doses

Smoking can affect the metabolism of clozapine, requiring dosage adjustments.

Question 5

What should be done when a patient stops smoking while on clozapine?

Answer 5

Decrease the doses by 60-70%, 10% per day over 4 days

Stopping smoking can lead to increased drug levels and potential toxicity.

Question 6

How does pregnancy affect CYP1A2 activity?

Answer 6

Activity decreases

Hormonal changes during pregnancy can alter enzyme activity.

Question 7

Can Luvox be used to enhance the effect of clozapine?

Answer 7

Yes

Luvox may be utilized to increase the therapeutic effect of clozapine.