Canadian Reference Guide Flashcards
Total daily dose range (mg) of Citalopram (Celexa)
20 - 60
Dosing of Citalopram (Celexa)
od or qhs
P450 Systems substrate of Citalopram (Celexa)
2C19, 3A4, 2D6
P450 Systems Inhibits or Induce of Citalopram (Celexa)
NOTHING ;)
Special considerations (Avoid, Caution, risk of) of Citalopram (Celexa)
1) Avoid MAOI’s or Ergot compounds
2) Risk SIADH (elderly)
3) Sexual dysfunction common, may be unreported
T1/2 (hours) Citalopram (Celexa)
30
Total daily dose range (mg) of Paroxetine (Paxil)
20 - 60
Special considerations (Avoid, Caution, risk of) of Paroxetine (Paxil)
1) Avoid MAOI’s or Ergot compounds
2) Risk SIADH (elderly)
3) Sexual dysfunction common, may be unreported
T1/2 (hours) of Paroxetine (Paxil)
30 - 65
Dosing of Paroxetine (Paxil)
od (or qhs)
P450 Systems substrate of Paroxetine (Paxil)
2D6
P450 Systems Inhibits or Induce Paroxetine (Paxil)
2D6 (Inhibit)
Total daily dose range (mg) of Sertraline (Zoloft)
50 - 200
Total daily dose range (mg) of Fluoxetine (Prozac)
20 - 80
Total daily dose range (mg) of Fluvozamine (Luvox)
100 - 300
Total daily dose range (mg) of Venlafaxine XR (Effexor XR)
75 - 225
Total daily dose range (mg) of Brupropion SR (Wellbutrin SR)
150 - 300
Total daily dose range (mg) of Moclobemide (Manerix)
450 - 900
Total daily dose range (mg) of Mirtazapine (Remeron)
30 - 60
Total daily dose range (mg) of Amitriptyline (Elavil)
100 - 300
Total daily dose range (mg) of Imipramine (Tofranil)
100 - 300
Total daily dose range (mg) of Clomipramine (Anafranil)
100 - 300
Total daily dose range (mg) of Nortriptyline (Aventyl)
75 - 200
Total daily dose range (mg) of Desipramine (Norpramin)
100 - 300
Total daily dose range (mg) of Phenelzine (Nardil)
30 - 90
Total daily dose range (mg) of Tranylcypromine (Parnate)
20 - 80
What is the total daily dose range for Citalopram (Celexa)?
20-60
This range indicates the typical dosage prescribed for effective treatment.
What is the dosing schedule for Citalopram (Celexa) ?
Od or qhs
‘Od’ refers to once daily, and ‘qhs’ refers to at bedtime.
What is the half-life (T1/2) of Citalopram (Celexa) in hours?
30
This indicates how long it takes for the concentration of the drug in the bloodstream to reduce by half.
Which P450 systems does Citalopram (Celexa) act as a substrate for?
2C19, 3A4, 2D6
These are specific cytochrome P450 enzymes involved in drug metabolism.
Does Citalopram (Celexa) inhibit or induce any P450 systems?
Nothing ;)
This indicates that Citalopram does not affect the activity of these enzymes.
What should be avoided when prescribing Citalopram (Celexa)?
MAOI’s or Ergot compounds
Combining these can lead to serious drug interactions.
What is a special risk associated with Citalopram (Celexa) in the elderly?
Risk SIADH
SIADH stands for Syndrome of Inappropriate Antidiuretic Hormone secretion, which can lead to hyponatremia.
What common side effect may occur with Citalopram (Celexa) that is often unreported?
Sexual dysfunction
This side effect can significantly affect a patient’s quality of life but may not always be disclosed.
