Psychoneuroimmunology Flashcards
What innervates bone marrow?
noradrenergic fibers
What innervates the thymus?
noradrenergic and peptidergic fibers
What innervates the spleen?
noradrenergic fibers
What innervates the lymph nodes?
noradrenergic and peptidergic fibers
What do T and B cells, neutrophils, mononuclear cells, and NK cells have receptors for?
catecholamines, ACh, neuropeptides
What is the effect of catecholamines on the immune system?
increase leukocyte mobilization (=increased NKC activity)
What is the effect of endorphins/enkephalins on the immune system?
increase T-cell reactivity and NK cell activity
True or false: Simply stated, stress is a stimulus or response.
False. Stress is also a process by which we appraise and cope with environmental threats and challenges.
Why does the # of various mononuclear cell populations decrease 1 hour after parachute jumping?
cells have localized to regional lymph nodes where they can respond to antigenic (infectious) challenge
What is the effect of cortisol during an acute, controllable stress response?
it stabilizes the leukocytes within the lymph node
What does the quick influence of catecholamines do during an acute stress response?
increases adhesion molecules on surface of leukocytes (CD11a) and activates cognate adhesion molecules on surface of endothelial cells (ICAM-1)
Cytokines produced as a consequence of an ongoing immune or inflammatory process can have direct effects on the CNS. These cytokines are:
IL1, IL6, TNFα
What are the cytokines that mediate sickness behavior?
IL1, IL6, TNFα
