Psychoisis

Question 1

When is the onset of schizo for males and females

Answer 1

Males - 18-25

Females - 25- mid 30’s and also around 45

Question 2

Men have more what symptoms than women? (With schizo)

Answer 2

More negative symptoms, social withdrawal, and incongruent affects

Question 3

What symptoms do most women have with schizo?

Answer 3

Mood disturbance and depression

Question 4

What does the Mesolimbic control?

Answer 4

Arousal

Memory

Motivation

Emotion

Pleasure

Question 5

What does the Mesocortical control

Answer 5

Cognition

Communication

Social function

Stress response

Question 6

What does the nigrostriatal control

Answer 6

Extrapyramidal system

Movement

Question 7

What does the tueroinfundibular control

Answer 7

Prolactin release

Question 8

How long can a person have schizo symtoms (prodromal or even residual) before diagnosis?

Answer 8

6 months

Question 9

How long should a person be off the substance, and still have the symptoms, to be diagnosed with an underlying psychosis issue.

Answer 9

One month

Question 10

Are positive or negative symptoms easier to treat with meds?

Answer 10

Positive

Question 11

What is the hardest to treat with meds?

Answer 11

Social skills

Question 12

What is the other name for first generation antipsychotics?

Answer 12

Typical

Question 13

What is the mechanism of action for first generation antipsychotics?

Answer 13

Dopamine receptor antagonist. They have a high affinity for D2 receptors

Question 14

What is the difference between first and second generation antipsychotics when it comes to picking for a pt?

Answer 14

They all work the same. The side effects are different

Question 15

Are FGA or SGA first line antipsychotics?

Answer 15

SGA - second generation

Question 16

What would you expect from low potency antipsychotics in regards to the affinity for receptors? What would you expect for side effects?

Answer 16

Low affinity for D2 but high affinity for other receptors such as Muscarinic, histamine, Alpha.

This can cause more side effects

Question 17

Low potency will cause less of what terrible side effect?

Answer 17

TD, and extrapyramidal

Question 18

What are the two low potency FGA?

Answer 18

Chlorpromazine

Thioridazine

(Clor and Thor) low potency

Question 19

What are the two high potency FGA?

Answer 19

Fluphenazine

Haloperidol

Question 20

What are the three things to remember with high potency FGA?

Answer 20

PO to IM conversion is not 1:1

Acute EPS my occur later and last longer

Neuroleptic malignant syndrome is more difficult to treat

Question 21

What do you need to do if picking a depot injection?

Answer 21

Make sure they have a good response to oral formulation first

Question 22

What is the first line treatment of schizo? With exception to what?

Answer 22

SGA AKA “atypical”

Clozapine (second line for refractory schizo

Question 23

Second generation has less, what side effects?

Answer 23

Less EPS
Less TD

Less hyperprolactinemia

Question 24

Second generation is better with less certain side effects, but what complications does it have?

Answer 24

Metabolic complications

Question 25

What is added to the second generation antiphychotics in regards to receptor. Which reduces what side effect

Answer 25

5HT2A receptor antagonist EPS

Question 26

Two thing to know about Asenapine

Answer 26

Can be SL Inhibits CYP2D6

Question 27

Three things to know about lloperidone?

Answer 27

1. Alpha 1 inhibitor 2. High rates of hypotension 3. If missed over 72 hours - you should titrate

Question 28

Three things to know about Lurasidone?

Answer 28

1. Low risk of weight gain 2. Must be taken with food 3. Can also use it for bipolar

Question 29

Olanzapine - what three things to know? And Forth about injection

Answer 29

1. Weight gain is high 2. Sedation is high 3. Same with Clozapine with smoking 4. Injection you have to watch them for 3 hours

Question 30

Quetiapine - What two thing to know about this drug

Answer 30

1. Low EPS symptoms | 2. Associated with less time to rehospitalization

Question 31

Risperidone - three things to know

Answer 31

1. First line 2. Risk for dose dependent EPS 3. Renal and Hepatic adjust dosing

Question 32

Paliperidone - three things to know

Answer 32

1. Active metabolite of Risperidone 2. Shell remains in stool 3. Injunction is monthly

Question 33

Two things to know about Ziprasidone

Answer 33

1. Take with food | 2. QTc is the largest risk to make it prolong

Question 34

What two meds cause hypotension? Because of this, they both have to be re-trilateral

Answer 34

Lloperidone clozapine

Question 35

What two meds do you have to take with food?

Answer 35

Ziprasidone Asenapine

Question 36

What are the three 2nd generation partial agonist?

Answer 36

Apiprprazole Brexpeprazole Cariprazine

Question 37

Aripiprazole- what effect on mesocortical system and Mesolimbic system?

Answer 37

Mesocortial agonist Mesolimbic Antagonist

Question 38

What are the three side effects of aripiprazole to know of

Answer 38

Akathisia Insomnia Dose related sedation

Question 39

What side effects does brexpiprazole have?

Answer 39

Akathisia Increased TG Weight gain

Question 40

Which one of the partial agonist cause the most weight gain and what causes the least

Answer 40

Most = Brex Least = Cari

Question 41

What has the least and most risk for somnolence when it comes to partial?

Answer 41

Most = Ari Least = Cari

Question 42

For parital agonst which one causes the most risk for Akathisia and the least

Answer 42

Most = Cari Least = brex