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Pharm Seizures > Psychoisis > Flashcards

Psychoisis Flashcards

1
Q

When is the onset of schizo for males and females

A

Males - 18-25

Females - 25- mid 30’s and also around 45

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2
Q

Men have more what symptoms than women? (With schizo)

A

More negative symptoms, social withdrawal, and incongruent affects

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3
Q

What symptoms do most women have with schizo?

A

Mood disturbance and depression

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4
Q

What does the Mesolimbic control?

A

Arousal

Memory

Motivation

Emotion

Pleasure

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5
Q

What does the Mesocortical control

A

Cognition

Communication

Social function

Stress response

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6
Q

What does the nigrostriatal control

A

Extrapyramidal system

Movement

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7
Q

What does the tueroinfundibular control

A

Prolactin release

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8
Q

How long can a person have schizo symtoms (prodromal or even residual) before diagnosis?

A

6 months

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9
Q

How long should a person be off the substance, and still have the symptoms, to be diagnosed with an underlying psychosis issue.

A

One month

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10
Q

Are positive or negative symptoms easier to treat with meds?

A

Positive

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11
Q

What is the hardest to treat with meds?

A

Social skills

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12
Q

What is the other name for first generation antipsychotics?

A

Typical

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13
Q

What is the mechanism of action for first generation antipsychotics?

A

Dopamine receptor antagonist. They have a high affinity for D2 receptors

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14
Q

What is the difference between first and second generation antipsychotics when it comes to picking for a pt?

A

They all work the same. The side effects are different

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15
Q

Are FGA or SGA first line antipsychotics?

A

SGA - second generation

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16
Q

What would you expect from low potency antipsychotics in regards to the affinity for receptors? What would you expect for side effects?

A

Low affinity for D2 but high affinity for other receptors such as Muscarinic, histamine, Alpha.

This can cause more side effects

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17
Q

Low potency will cause less of what terrible side effect?

A

TD, and extrapyramidal

18
Q

What are the two low potency FGA?

A

Chlorpromazine

Thioridazine

(Clor and Thor) low potency

19
Q

What are the two high potency FGA?

A

Fluphenazine

Haloperidol

20
Q

What are the three things to remember with high potency FGA?

A

PO to IM conversion is not 1:1

Acute EPS my occur later and last longer

Neuroleptic malignant syndrome is more difficult to treat

21
Q

What do you need to do if picking a depot injection?

A

Make sure they have a good response to oral formulation first

22
Q

What is the first line treatment of schizo? With exception to what?

A

SGA AKA “atypical”

Clozapine (second line for refractory schizo

23
Q

Second generation has less, what side effects?

A

Less EPS
Less TD

Less hyperprolactinemia

24
Q

Second generation is better with less certain side effects, but what complications does it have?

A

Metabolic complications

25
Q

What is added to the second generation antiphychotics in regards to receptor. Which reduces what side effect

A

5HT2A receptor antagonist

EPS

26
Q

Two thing to know about Asenapine

A

Can be SL

Inhibits CYP2D6

27
Q

Three things to know about lloperidone?

A
  1. Alpha 1 inhibitor
  2. High rates of hypotension
  3. If missed over 72 hours - you should titrate
28
Q

Three things to know about Lurasidone?

A
  1. Low risk of weight gain
  2. Must be taken with food
  3. Can also use it for bipolar
29
Q

Olanzapine - what three things to know? And Forth about injection

A
  1. Weight gain is high
  2. Sedation is high
  3. Same with Clozapine with smoking
  4. Injection you have to watch them for 3 hours
30
Q

Quetiapine - What two thing to know about this drug

A
  1. Low EPS symptoms

2. Associated with less time to rehospitalization

31
Q

Risperidone - three things to know

A
  1. First line
  2. Risk for dose dependent EPS
  3. Renal and Hepatic adjust dosing
32
Q

Paliperidone - three things to know

A
  1. Active metabolite of Risperidone
  2. Shell remains in stool
  3. Injunction is monthly
33
Q

Two things to know about Ziprasidone

A
  1. Take with food

2. QTc is the largest risk to make it prolong

34
Q

What two meds cause hypotension? Because of this, they both have to be re-trilateral

A

Lloperidone

clozapine

35
Q

What two meds do you have to take with food?

A

Ziprasidone

Asenapine

36
Q

What are the three 2nd generation partial agonist?

A

Apiprprazole

Brexpeprazole

Cariprazine

37
Q

Aripiprazole- what effect on mesocortical system and Mesolimbic system?

A

Mesocortial agonist

Mesolimbic Antagonist

38
Q

What are the three side effects of aripiprazole to know of

A

Akathisia

Insomnia

Dose related sedation

39
Q

What side effects does brexpiprazole have?

A

Akathisia

Increased TG

Weight gain

40
Q

Which one of the partial agonist cause the most weight gain and what causes the least

A

Most = Brex

Least = Cari

41
Q

What has the least and most risk for somnolence when it comes to partial?

A

Most = Ari

Least = Cari

42
Q

For parital agonst which one causes the most risk for Akathisia and the least

A

Most = Cari

Least = brex

Pharm Seizures (8 decks)

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