Depression

Question 1

What does SSRI’s end in?

Answer 1

-lopram

Question 2

What SSRI is the most anticholinergic?

Answer 2

Paroxetine

Question 3

What SSRI have the lowest risk of drug interactions?

Answer 3

Escitalopram

Question 4

What side effect can Citalopram cause

Answer 4

Prolong QTc

Question 5

Because of the prolonged QTc with citalopram, what is the FDA warning for dosing

Answer 5

40 mg max up to age 65

20 mg for 65 and older

Question 6

What side effects can be transient during the first few weeks

How can you change things to help with those side effects if they are bad

Answer 6

Nausea and headaches

Start low and take with food

Question 7

What is Vilazodone?

What is it approved for?

Answer 7

SSRI with 5HT1A partial agonist (like SSRI and Buspirone)

MDD

Question 8

What is the biggest side effect with Vilazodone?

Answer 8

Nausea, many people wont take it because of this

Question 9

When taking Vilazodone, what should you keep in mind when taking food?

Answer 9

Food affects absorption.

Consistently take with or without food

Question 10

What was added to Vortioxetine to fix the issues with Vilazodone?

Answer 10

5HT3 antagonist

To help with nausea

Question 11

Does food affect the absorption of Vortioxetine?

Answer 11

No

Question 12

What does SNRI’s end in?

Answer 12

Faxine

And pran

Question 13

What is SNRI also good for besides depression?

Answer 13

Neuropathic pain and fibromyalgia

Question 14

At low levels what effect does SNRI give? What does it give at higher doses?

Answer 14

SSRI effect

Higher it gives a NE and dopamine affect

Question 15

What is Milnacipran for?

Answer 15

Fibromyalgia

Question 16

What are the two SNRI that is only good for MDD

Answer 16

Desvenlafaxine and levomilnacipran

Question 17

What kind of toxicity can Duloxetine cause?

Answer 17

Hepatotoxicity

Question 18

TCA is divided into two groups, what are the groups and which ones has less side effects?

Answer 18

Tertiary amines

Secondary amines - these have less side effects

Question 19

What are the three secondary amines of TCA

Answer 19

Desipraimine
Nortriptyline
Protriptyline

Question 20

What are the adverse effects of TCA

Answer 20

Anticholinergic
Weight gain
Hypotension
Sexual dysfunction
Decrease seizure threshold 
Cardiac conduction delays

Question 21

What is TCA contraindicated in?

Answer 21

Post-MI and pts with cardiac issues

Question 22

What TCA has the be way of monitoring?

Answer 22

Nortriptyline

Question 23

MOA of MAOI?

Answer 23

Target serotonin and NE

Question 24

What is the only antidepressant that is meant for Postpartum depression

Why is it never used?

Answer 24

Brexanolone

60 hour infusion

$30,000 per infusion