Depression Flashcards
What does SSRI’s end in?
-lopram
What SSRI is the most anticholinergic?
Paroxetine
What SSRI have the lowest risk of drug interactions?
Escitalopram
What side effect can Citalopram cause
Prolong QTc
Because of the prolonged QTc with citalopram, what is the FDA warning for dosing
40 mg max up to age 65
20 mg for 65 and older
What side effects can be transient during the first few weeks
How can you change things to help with those side effects if they are bad
Nausea and headaches
Start low and take with food
What is Vilazodone?
What is it approved for?
SSRI with 5HT1A partial agonist (like SSRI and Buspirone)
MDD
What is the biggest side effect with Vilazodone?
Nausea, many people wont take it because of this
When taking Vilazodone, what should you keep in mind when taking food?
Food affects absorption.
Consistently take with or without food
What was added to Vortioxetine to fix the issues with Vilazodone?
5HT3 antagonist
To help with nausea
Does food affect the absorption of Vortioxetine?
No
What does SNRI’s end in?
Faxine
And pran
What is SNRI also good for besides depression?
Neuropathic pain and fibromyalgia
At low levels what effect does SNRI give? What does it give at higher doses?
SSRI effect
Higher it gives a NE and dopamine affect
What is Milnacipran for?
Fibromyalgia
What are the two SNRI that is only good for MDD
Desvenlafaxine and levomilnacipran
What kind of toxicity can Duloxetine cause?
Hepatotoxicity
TCA is divided into two groups, what are the groups and which ones has less side effects?
Tertiary amines
Secondary amines - these have less side effects
What are the three secondary amines of TCA
Desipraimine
Nortriptyline
Protriptyline
What are the adverse effects of TCA
Anticholinergic Weight gain Hypotension Sexual dysfunction Decrease seizure threshold Cardiac conduction delays
What is TCA contraindicated in?
Post-MI and pts with cardiac issues
What TCA has the be way of monitoring?
Nortriptyline
MOA of MAOI?
Target serotonin and NE
What is the only antidepressant that is meant for Postpartum depression
Why is it never used?
Brexanolone
60 hour infusion
$30,000 per infusion
