psychiatry drugs Flashcards
types of antidepressant drugs
- monoamine oxidase inhibitor
- monoamine reuptake inhibitors
- atypical
examples of monoamines
- dopamine
- noradrenaline
- 5-hydroxytryptophan
what is decreased in depression
monoamines
MOA of monoamine oxidase inhibitors
irreversible or reversible inhibitors of MOA-A and B
examples of monoamine oxidase inhibitors
- phenelzine
- moclobemide
side effects of monoamine oxidase inhibitors
- cheese reaction
- decrease other drug metabolism
- insomnia
- postural hypotension
- peripheral oedema
what is cheese reaction caused by monoamine oxidase inhibitor
aka hypertensive crisis
caused by inhibition of MOA-A in gut which prevents the breakdown of tyramine
what are the type of monoamine reuptake inhibitors
- tricyclics
- non selective reuptake inhibitor
- selective serotonin reuptake inhibitor
- noradrenaline reuptake inhibitor
MOA of tricyclic antidepressants
block the reuptake of monoamine into presynaptic terminal
examples of tricyclics
- imipramine
- dosulepin
- amitriptyline
- lofepramine
side effects of tricyclics
- blurry vision
- dry mouth
- constipation
- sedation
- weight gain
- postural hypotension
- tachycardia
- cardiotoxic in overdose
SSRI MOA
selectively inhibit reuptake of serotonin from synaptic cleft
examples of SSRI
- fluoxetine
- citalopram
- sertraline
SE of SSRI
- nausea
- headache
- worsened anxiety
- increase in self harm
- sweating
- sexual dysfunction
- hyponatraemia (elderly)
MOA OF NSRI
block reuptake of monoamines into presynaptic terminal
