Psychiatry Department Exam Review Packet Flashcards
1st Mood Stabilizer for Bipolar
Lithium
Which 2 psych drugs are suicide protective?
Lithium
Clozapine
Which tests do you need to order for Lithium
Serum Level (0.6-1.2 approx; >1.4 is toxic)
Thyroid Level (for hypothyroidism)
BUN/Cr (Renally excreted)
ECG (Arrhythmia risk)
What patients should NOT receive Lithium
Pregnant - Ebstein Heart Defect Diuretics NSAIDs Medications impairing renal function Renal Problems Heart Conditions (Arrhythmia risk)
Common SE of Lithium
GI Weight Gain Acne Fine Tremor Thirst (2/2 polyuria) Hair Loss
Rare SE of Lithium
Hypothyroid
Arrhythmia/CHF
Neurotoxicity
Which anticonvulsant is hepatotoxic?
Depakote
Risk of Depakote use
Increase risk of PCOS
Can affect liver and pancreas -> hemorrhagic pancreatitis
Lab tests for Depakatoe
LFT
CBC for platelets
Which anticonvulsant causes agranulocytosis?
Carbamazepine (Tegretol)
Lab tests to order for Carbamazepine
CBC
LFT- hepatic inducer
BMP- risk of hyponatremia
What anticonvulsant can cause arrhythmia in OD
Carbamazepine
What anticonvulsant may cause neural tube defects?
Depakote
Carbamazepine
Neonatal SE of Lithium
Ebstein’s
Neonatal SE of Lamictal
Cleft Lip/Palate
Dangerous condition when patient gets Lamotrigine + Depakote
SJS
Appropriate serum level of Depakote
50-100 is therapeutic
Which anticonvulsant is associated with risk of kidney stones
Topiramate (Topamax)
Which has higher risk of EPS and TD, Haldol or Thorazine?
Haldol (High potency)
SE of Compazine (Thorazine)
Orthostatic Hypotension
Anticholinergic
Sedation
*Less risk of EPS/TD
Which antipsychotic is NOT metabolized hepatically?
Paliperidone- almost all renal excretion
Which antipsychotics need an EKG done and why?
Prolong QTc
Compazine (Thorazine)
Ziprasidone (Geodon)
Clozapine
Antipsychotic with lowest risk of EPS and TD
Seroquel (Quetiapine0
Clozapine
Treatment for EPS
Amantadine
Benedryl
Benztropine
Proven treatment for TD
Only Cloazpine
Which drug is best for treating negative symptoms in psychosis
Clozapine
SE Profile of Clozapine
Agranulocytosis Prolong QTc WORST Weight gain/Metabolic Syndrome Anticholinergic Antimuscarinic Antihistamine High sedation Seizures
Which antipsychotic is most associated with akathesia?
Aripiprazole (Abilify)
Which atypical antipsychotic most increases Prolactin?
Risperidone
What antipsychotic most commonly causes orthostatic hypotension in elderly?
Seroquel
Best atypical to use in Parkinson’s or Lewy Body Dementia
Seroquel
Which antipsychotic has worst weight gain?
Clozapine
Olanzapine(Zyprexa)
Compazine (Thorazine)
Best antipsychotic for liver failure
Paliperidone
Antipsychotic that needs to be taken with meals
Ziprasidone
Name the SNRIs and 2 Mixed Action Antidepressants
Venlafaxine (Effexor)/Desvenlafaxine
Duloxetine (Cymbalta)
Buproprion (Wellbutrin)
Mirtazepine (Remeron)
SE of Venlafaxine (Effexor)
NEW diastolic HTN (do not use in HTN patients)
Sexual dysfunction
SE of Duloxetine (Cymbalta)
Increased LFT
Sexual Dysfunction
What is Cymbalta good for?
Patients with neuropathy
SE of Buproprion (Wellbutrin)
Lower seizure threshold (avoid in ETOH and BN/AN)
May WORSEN anxiety
Benefits of Buproprion
No sexual dysfunciton
May cause weight loss
SE of Mirtazepine (Remeron)
Highly Sedating (take at bedtime) Increase Appetite
Benefits of Mirtazepine (Remeron)
No sexual dysfunction
No worsening of anxiety (in contrast to Wellbutrin)
Increase appetite
TCA Antidepressants
Imipramine/Desipramine
Amitryptaline/Nortryptaline
Clomipramine
Doxepin
Antidepressants without Sexual SE
Mirtazepine
Burproprion
Major SE of Cymbalta (Duloxetine)
Inc LFT
Major SE of Effexor (Venlafaxine)
New Diastolic HTN
Major SE of Buproprion (Wellbutrin)
Decrease seizure threshold
Worsen anxiety
Worst SSRI for discontinuation syndrome
Paroxetine (Paxil)
Fluvoxamine (Luvox)
SSRI with worst weight gain
Paroxetine (Paxil)
Signs and Sx of SSRI Discontinuation Syndrome
Irritability
Unstable Gait
Rebound Anxiety
electric like shocks (Lhermitte)
Which SSRI are best for avoiding discontinuation sydrome
Fluoxetine (Prozac)
Citalopram (Celexa)
Three C’s of TCA overdose
Cardiotoxicity
Convulsions
Coma
Signs of NMS
"FALTER" Fever Autonomic Instability Leukocytosis Tremor Elevated CK Rigidity
What HTN med can be given for nightmares in PTSD
Prazosin (alpha blocker)
SE of Trazodone
Priaprism
MAO-I + Tyramine excess =?
HTN Crisis => Stroke, Aneurysm
Which MAO-i binds reversibly
Meclobemide
Which MAO-i bind irreversibly
Phenylzine
Tranylcypromine
Selegiline
Nonstimulant option for ADHD
Atomoxetine
Slower onset-> less abuse potentional
also used for Narcolepsy
At what age can you give amphetamines for ADHD
After 3 years old
At what age can you give methylphenidate for ADHD
After 6 years old
Why can’t stimulants be given to ADHD Children if they have hx of HTN, psychosis or seizures
Inc NE => Worsen HTN
Inc Dopamine => Worsen Psychosis
Increased activity/excitation => Worsen seizures
Criteria A Signs and Sx of Schizophrenia
Hallucinations (Auditory MC)
Delusions
Disorganized Thinking/Behavior
Negative Sx
What are the negative sx of Schizophrenia
"5As" Anhedonia Affect (poor) Alogia Avolition Attention (poor)
How many A sx are needed to meet criteria for Schizophrenia
2 out of 5 for at least 1 month
*Unless delusions are bizarre or multiple voices or continuous voices
Duration of Symptoms for Schizophrenia Spectrum Disorders
At least 6 months => Schizophrenia
1-6 months => Schizophreniform
<1 month => Brief Psychotic Disorder
Criteria B for Schizophrenia
Social Occupational Dysfunction: work, interpersonal relationships, self care
What developmental disorders can present with psychosis
Asperger’s
Rhett’s Disorder
Autism (10x more common than Schizo in kids)
What personality disorders can have odd behavior
Cluster A: Paranoid, Schizoid, Schizotypal
What medications can cause psychosis
Steroids
Who gets schizophrenia more, M or F?
M=F; But M with more severe illness
Age of onset for schizophrenia
M: 15, 18-25 years
F: 25-40years
Most common time schizophrenics may attempt suicide?
During remission of illness just after a relapse
*Younger M who are DOING WELL with GOOD insight are highest risk
Cognitive Deficits of Schizophrenia
SMART Speed of Thinking Memory Attention Reasoning Tact
General Lifespan for Schizophrenic. Why?
~50 years
Substance Abuse (Smoking, etoh)
Suicide
Increased CV Risk
Brain Tracts and Associations
Nigrostriatal: EPS (Dystonia, Parkinsonism, Akathesia, TD
Tuberoinfudinbular: Prolactin
Mesolimbic: Psychosis (increased with DA inc)
Mesocortical: responsible for negative signs and sx
Treatment Algorithm for Schizophrenia
1: SGA
2: Different SGA or Try FGA
3: Consider Clozapine
4: Clozapine + SGA/FGA
5: Modify SGA/FGA from stage 4
6: 2 FGA/2SGA/1 of each
How long is adequate anti-psychotic trial
4 weeks at therapeutic dose
*Patients should have SOME response within 2 weeks
MC method of suicide for both sexes? 2nd most common Individually?
Firearms MC
M: hanging
F: Drug OD
Highest Suicide Rate Country
- Lithuania
2. Japan
Risk factors for Suicide
Male Age >65 or Adolescent Whites Prior Attempt Divorced Family Hx HIstory of Abuse in Childhood Mental Illness Substance Abuse Other co-morbid medical conditions
Protective Factors for Suicide
Social Support
Religion
Parents with children
Which sex completes more suicide?
Male (3x more)
Which sex attempts more suicide?
Women (4x more)