Bipolar Disorder Flashcards

1
Q

Bipolar I or Biplolar II:

Delusions

A

Bipolar I

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2
Q

Bipolar I or Biplolar II:

Symptoms may be present for 4-6 days

A

Bipolar II

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3
Q

Bipolar I or Biplolar II:

May present with mixed features

A

Both

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4
Q

Bipolar I or Biplolar II:

Depressive Episode NOT a diagnostic requirement

A

Bipolar I

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5
Q

Bipolar I or Biplolar II:

Patients are typically in depressed state 15x more than hypomanic state

A

Bipolar II

Bipolar I: depressed 2x more than manic)

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6
Q

Bipolar I or Biplolar II:

Can be mistaken for cyclothymia

A

Bipolar II

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7
Q

Bipolar I or Biplolar II:

More likely to have hypomanic episode

A

Bipolar I

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8
Q

Bipolar I or Biplolar II:

Cause signfiicant impairment in social or occupational function, necessitating psychiatric hospitalization

A

Bipolar I

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9
Q

Bipolar I or Biplolar II:

Equal likelihood between males and females

A

Bipolar I

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10
Q

Gender more likely to have 1st mood disturbance be a manic episode

A

Males

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11
Q

% risk of future mood episode if 1st mood disturbance is manic episode

A

85%

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12
Q

What is the risk of bipolar disorder if your identical twin has it?

A

70%

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13
Q

Average age of onset for Bipolar I and Bipolar II

A

Bipolar I: 18

Bipolar II: Mid-20s

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14
Q

What happens to length of manic episode with each ensuing episode

A

Lengthens/Increases

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15
Q

Which side of family, if affected, carries lower risk of bipolar disorder

A

Paternal Side (Father)

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16
Q

After 1st mood disturbance in Major Depression, risk of future depression episode is:

A

50%
After 2 episodes: 70%
After 3 episodes : 90%

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17
Q

For patients with bipolar disorder, as the total number of mood episodes increases, the interepisode
interval does this

A

Shortens/Decreases

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18
Q

Average lifetime # of manic episodes a patient will have is? Unless what is done?

A

9-10 episodes

Need maintenance medication treatment

19
Q

Which medication is avoided in treating bipolar patients with liver disease?

A

Depakote

20
Q

Which medication can be rapidly loaded in bipolar patients, showing improvmeent in first 3 days

A

Depakote

21
Q

What is the Rule of 1/3 in Bipolar Disorder

A

Lithium or Depakote Monotherapy successfully treat manic episodes to resolution in 1/3 of patients

Rule: 1/3 respond well, 1/3 partial response, 1/3 respond poorly

22
Q

Lithium’s response rate in treating bipolar patients with euphoric mood, family history of the illness, and/or few lifetime episodes is this

A

70% (GOOD)

23
Q
Lithium       		
Lithium + FGA/SGA
Divalproex (Depakote)
Divalproex (Depakote) + FGA/SGA
-------------------------------
The first choice for treating a severe 
acute manic episode is this
A

Lithium + FGA/SGA or divalproex (depakote) + FGA/SGA

24
Q

When is maintenance treatment always recommended?

A

After 2 manic episodes

Usually given after 1 episode as well

25
Q

Which bipolar disorder medicaiton decreases risk of suicide?

A

Lithium

26
Q

Which medication is avoided in treating bipolar patients with renal disease?

A

Lithium

27
Q

Which medication is avoided in treating bipolar patients who are obse?

A

Olanzapine (Zyprexa)

28
Q

What can happen if Lithium is discontinued abruptly over days? How is this avoided

A

Affective Switch to Mania

Lower risk by discontinuing gradually over months

29
Q

What medication combination is effective in treating bipolar depression with no increased risk of switch to manic episode?

A

Symbyax: Olzanzapine +Fluoxetine

30
Q

Which antidepressants lead to increased switch rate and increased number of rapid cycling cases?

A

TCA and SNRIs

31
Q

What is contraindicated in treatment of bipolar I Depression

A

Antidepressant Monotherapy

32
Q

Which antidepressant has least risk of inducing a manic episode

A

Buproprion (Wellbutrin)

33
Q

What medications are recommended for treating bipolar depression

A
Lithium
Quetiapine (Seroquel)
Lurasidone (Latuda)
Lamotrigine (Lamictal)
Olanzapine/Fluoxetine (Symbyax)
34
Q

While often used as an adjunct treatment of major depression, this SGA is NOT shown to be beneficial in the treatment of bipolar depression

A

Aripiprazole (Abilify)

35
Q

When using an antidepressant to treat bipolar depression, this should be done after the episode has remitted

A

Discontinue the antidepressant

36
Q

What can Lamotrigine be used for?

A

Treat acute bipolar depression

Maintenance treatment

37
Q

What should Lamotrigine NOT be used for?

A

NOT for acute manic episode

38
Q

Which bipolar medication has the narrowest gap between therapeutic and toxic concentration in psychiatry

A

Lithium

39
Q

To rapidly load a patient weighing

150 pounds with 20 mg/kg of divalproex (depakote), this amount of the medication is prescribed

A

1500mg

40
Q

% of bipolar patients who dies by suicide

A

16% (20x risk of general population)

41
Q

How is severe lithium toxicity treated

A

Dialysis

42
Q

What symptom is indicative of onset of new manic episode

A

decreased need for sleep

43
Q

Mania then depression or
Depression then mania

This happens 60% of the time

A

Mania then Depression

44
Q

Individuals in a manic episode frequently resist efforts to treat them because they do not recognize that they are ill which is called this

A

Anosognosia (lack of insight)