Psychiatry Flashcards

1
Q

How common is mental illness?

A

1) 1 in 3 will have mental health disorder in lifetime
2) 1 in 3 GP consultations have mental health component
3) Most people fully recover

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How do people with mental illnesses feel stigmatised?

A

1) 3 in 4 people feel stigmatised
2) Many people scared to discuss illness
3) Only 10% of NHS funding
4) Real-term cut in funding
6) Six weeks in most undergraduate courses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What treatments are available for mental illness?

A

A range of treatment options are available, with an excellent evidence base, such as:
> Psychotherapies
> Social therapies
> Medication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the differences between mental illness and physical illness?

A

1) People often do not perceive themselves to be ill
> No “therapeutic contract”
> Reluctance to accept treatment
> Use of Mental Health Act (50,000 detentions per year)
2) No scientific basis to diagnosis
> Similar to 18th Century medicine
> Diagnose by symptom cluster - not aetiology or pathology
> Uncertainty about diagnosis
> Dispute about existence of mental illness
3) Perceived lack of treatment
4) Agents of social control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the symptoms of periods of intense anxiety?

A

1) Sudden fear
2) Heart racing
3) Shaking
4) Dry mouth
5 Last 10-15 minutes then subside

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the symptoms of obsessional thought?

A

1) Ruminating on germs
2) Knowing they’re senseless thoughts
3) Being their own thoughts
4) Trying and failing to resist thoughts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is pathogical anxiety and what are its symptoms?

A

This is a feeling of fear or dread, that is part of normal life. It becomes pathological when it begins to affect daily life, to the extent that i5 becomes disabling. It is characterised by physical symptoms in a positive feed back loop, including:

1) Palpitations
2) Sweating
3) Dry mouth
4) Splanchnic vasoconstriction (butterflies)
5) Tremor
6) Paraesthesia (pins & needles)
7) Depersonalisation
8) Syncope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are compulsions?

A

These are motor response to obsessional thoughts and are often ritualistic, stereotyped and precise. Examples of compulsions include:
•Handwashing
•Counting
•Arranging and symmetry
•Checking door locks
The entire process usually starts again if interrupted or in case of doubt.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are obsessions?

A

These are ego-dystonic thoughts, meaning one’s own thoughts that make them uncomfortable. These are usually repetitive, circular ruminations that may be bizarre and sound delusional. Insight is maintained, so one does not accept obsessions as a fact. Obsessions are unbidden and resisted, but resistance leads to anxiety.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How is anxiety classified?

A
Anxiety can be classified as:
•Generalised anxiety disorder
•Panic disorder
•Agoraphobia (fear of going out)
•Simple phobia (e.g. snakes, spiders, thunder) 
•Social phobia

Some disorders that used to be classified as anxiety, but no longer are, include:
•Obsessive Compulsive disorder
•Post traumatic stress disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Why are anxiety disorders important?

A

1) While they represent a comparatively heterogenous set of conditions, with a considerable ‘clinical iceberg’, under-diagnosis and under-treatment is common.
2) Anxiety disorders are believed to be increasing in prevalence.
3) Anxiety can be the beginning of a trajectory associated with eating disorders and self-harm – both of which are strongly associated with parasuicide and suicide.
4) Globally it is difficult to quantify the burden of anxiety due to varying diagnostic criteria and cultural contexts.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the inequalities of anxiety disorders in the UK?

A

1) Diagnosed more commonly among women than men.
2) 60% of LGBT community report anxiety in last 12 months.
3) Slightly higher prevalence among ethnic minorities in UK.
4) Prevalence of mixed anxiety and depression as high as 60% among social care users.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is anxiety?

A

Anxiety is normal (and useful!)! it is only a ‘disorder’ if it is excessive, so impacts on life or out of context. It is the most common cause of mental disorder with estimates of lifetime prevalence of between 14 and 33%. It is more common in females (2:1) and has a median onset age of 11.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How can anxiety be managed?

A

1) Course of cognitive behavior therapy (CBT), either in a group, individually or online. A trained therapist, not psychiatrist, usually a psychologist or nurse or allied health professional, delivers the treatment over a period of weeks (~12-16 weeks). The patient sets the goal as to what they want to get out of the therapy.
2) Clomipramine, an ancient antidepressant but with good evidence base for OCD.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Why do psychiatrists do home visits?

A

1) It’s more efficient, they are more likely to see the patient. Up to 50% of patients don’t turn up to psychiatric clinics in hospitals.
2) The patient does not have to travel, or go to a psychiatric hospital,with all the stigma attached to that.
3) The patient can be observed in their own environment, which gives away a huge number of clues.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the symptoms of depression?

A
1) Core features:
     > Pervasive low mood/sadness
     > Loss of energy (anergia)
     > Loss of enjoyment (anhedonia)
2) Physical symptoms: 
     > Loss of appetite
     > Weight loss
     > Diurnal variation of mood
     > Poor sleep
     > Loss of libido
     > Constipation
     > Psychomotor slowing or agitation
3) Psychological symptoms:
     > Poor concentration
     > Feelings of guilt
     > Feelings of hopelessness
     > Low self-esteem
     > Indecisive
     > Suicidal ideation
     > Delusions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Why is depression important?

A

Depression is important because:

1) In the NHS it consumes a huge proportion of resource: whether directly through mental health support and pharmaceuticals, but more so in affecting resilience and likelihood to self-care for a range of other conditions.
2) Globally it is the leading cause of disability and is increasing in diagnosed prevalence: largely driven by greater awareness and more timely diagnosis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the inequalities of depression in the UK?

A

1) Surprisingly, the prevalence of depression is fairly consistent across deprivation deciles.
2) Women are twice as likely to be diagnosed than men.
3) 50% of LGBT community report depression in last 12 months.
4) Depression is much more common in the north of England than in London and the south.
5) People with depression are less likely to self-care and very likely to become socially isolated as they fall out of

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Outline the prevalence of suicide

A

1) There are over 6000 suicides in UK annually, making it a significant public health burden.
2) It is the single most common cause of death in young men aged 18-25 and rates are only rising in young and middle aged men.
3) The male to female ratio of suicide being 3:1, but 3x as many women attempt suicide and self harm than men.
4) Hanging is most common method of suicide.
5) Suicide is most commonly associated with drug/alcohol use disorders and depression.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

How is depression treated?

A

1) Medication: Antidepressants (e.g. Venlafaxine)
> Response after 2-3 weeks, sometimes up to 6 weeks before patients get back to an even keel
2) Psychological therapies
> 12 session cognitive behavioural therapy
3) Social prescribing
> Exercise, company
- 90% of patients make a full recovery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is bipolar disorder?

A

This affects 1% of the population, who flip between depression and being manic. The periods of depression are indistinguishable from those suffering from pure depression, they may even recover and have several years of normal function, but then get another episode of depression or mania.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are the symptoms of mania?

A

1) Elated mood
2) Irritability
3) Over-energized
4) Grandiose
5) Little need for sleep
6) Poor concentration
7) Poor judgement
8) Over-spending
9) Rapid speech

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the symptoms of schizophrenia?

A

1) Hallucination: hearing, seeing or feeling things that are not there.
2) Delusion: fixed false beliefs not shared by others in the person’s culture and that are firmly held even when there is evidence to the contrary.
> Passivity
> Thought alienation
3) Abnormal Behaviour: disorganised behavior such as wandering aimlessly, mumbling or laughing to self, strange appearance, self-neglect or appearing unkempt
4) Disorganised speech; incoherent or irrelevant speech, neologisms and formal thought disorder
5) Disturbances of emotions: marked apathy or disconnect between reported emotion and what is observed such as facial expression or body language

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is schizophrenia?

A

It’s is a formal thought disorder, where one is incapable of following the semantic and syntactic rules of language.

25
Q

What are the two major psychotic disorders?

A

The major two psychotic disorders are schizophrenia and bipolar affective disorder (BPAD) – together they are described in population health as ‘Severe Mental Illness’ or SMI.

26
Q

How do schizophrenia and bipolar affective disorder (BPAD) present themselves?

A

1) Both are typically episodic and can be well-managed in many cases.
2) Schizophrenia, with its teenage onset, typically disrupts education, family life and relationships.
3) BPAD tends to occur later once education and early career goals have been achieved. Its impact is less pronounced and highly varied.

27
Q

What are the severe mental illness (SMI) inequalities in the UK?

A

1) Adults with SMI are twice as likely to have long term conditions, and poorer health outcomes because of this.
2) Strongly associated with smoking, alcohol and substance misuse: psychosis is associated with cannabis consumption.
3) Life expectancy is reduced by 15-20 years in patients with SMI.
4) Inequalities in diagnosis and treatment for psychosis among migrant populations remains an area of active investigation and population health concern.

28
Q

How is schizophrenia treated?

A

1) Antipsychotics
2) Psychological therapies
3) Family therapy
4) Arts therapies

29
Q

What are the 4 main functions of the brain?

A

1) Organising sensory input
2) Make sense of sensory + social information
• Predictive models
3) Motivating survival
•Avoid harm (physical, social)
4) Maximising efficiency

30
Q

Define compulsion

A

Compulsion is the experience of overwhelming urges to repeat a behaviour, even in the knowledge that it is harmful. It is present in numerous related disorders, known as trans-diagnostic phenomena. These include:

1) Anxiety
2) Depression
3) Self-harm
4) Addiction
5) OCD
6) Eating disorder

31
Q

What is anxiety?

A

Anxiety disorder can be conceptualised as a self-perpetuating network of positive feedback loops, arising from normally adaptive responses.

32
Q

Outline the 2 concepts explaining how anxiety develops

A

1) Trait anxiety - an individual’s propensity to experience anxiety under a certain set of stresses
> Low trait anxiety associated with higher mortality before the age of 25
> It is based on a mixture of genetic factors (i.e. polymorphism sod serotonergic and noradrenergic function) and environment, anxiety disorders tend to be 40% heritable.
2) State anxiety - the feeling of anxiety
> Automatically motivates to avoid harm
> Introduces attention and cognitive bias, changing the way information is perceived and rationalised
> Rumination, so automatic negative thoughts about possible threats
> Poor sleep affects brain function

33
Q

What are the characteristics of depression?

A

1) Low mood
2) Anhedonia - lack of positive experiences
3) Depressogenic stressors - abuse, loss, bullying, chronic illness
4) Prolonged stress - could be an evolutionary automatic recuperative response
5) Low self worth/esteem - adjusted self perception of worth
6) Social withdrawal and isolation
7) Hopelessness and thoughts of suicide

34
Q

What is self-harm?

A

Self-harm typically occurs in the context of low self-worth and persistent distress - it serves many functions, mainly related to reducing this distress.

35
Q

What are the 2 broad categories of self-harm?

A

1) Self-harm with the intention of suicide
2) Non-suicidal self-injury (NSSI): cutting, burning, skin-picking, pinching, ingesting objects, scratching, hitting, hair-pulling, poisoning.

36
Q

Why do people self harm?

A

1) They hate themselves
2) They believe that they deserve to be punished
3) They fear punishment that they cannot control
4) Temporary release from anxiety
> Control of punishment – feel safe
> Endogenous injury response - release of endogenous opioids and cefalins, happy chemicals, that temporary numb pain and fear

37
Q

What are the differences between positive and negative reinforcement?

A

1) Positive reinforcement: feeling fine and something occurs that makes one feel even better, causing that behaviour to be associated with a positive thing.
2) Negative reinforcement: feeling in a constant state of anxiety, distress, tension and something occurs that relieves that negative state. This releases dopamine, causing the brain to associate bad things with a positive outcome.

38
Q

Outline the characteristics of compulsion

A

1) State of distress
2) Distress reducing behaviour
> Self-harm
> Substance use
> Disordered eating
> Compulsive rituals
3) Temporary relief
4) Negative reinforcement
5) An urge to repeat that behaviour - repetition leads to habit formation as behaviour begins go happen automatically at an unconscious level

39
Q

What is addiction?

A

Repeated negative reinforcement, in the context of persistent states of suffering/ distress/tension, is a central part of the development of addictions. Addictions have a powerful unconscious component, mediated by the substances’ direct action on neural circuits for motivation and reward-seeking. The social context of addictions is absolutely central to their development.

40
Q

What is Obsessive-Compulsive Disorder (OCD)?

A

This is characterised by intrusive thoughts/images. These intrusive thoughts are distressing and involuntary and drive compulsive behaviours, which serve to relieve state of anxiety/tension. Negative reinforcement, driven by the distress caused by the intrusive thoughts, and cemented by habit-formation, are central to compulsion in OCD.

41
Q

What are the characteristics of eating disorders?

A

1) Low self-worth and anxiety
> Projected onto the body
> Hugh calories food gives a neural reward and creates a compulsive cycle of negative reinforcement.
2) Diet restriction
> Eating leads to feelings of failure and loss of control, leading to binge eating disorders (e.g. bulimia nervosa). Intense distress leads to purging and temporary relief, hence fuelling this compulsive cycle.
> Weight loss leads to safety, control and achievement and fear of failure and loss of control (e.g. anorexia). Lack of nutrition leads to brain starvation, causing cognitive inflexibility, and the incapability of thinking of other ways to cope, hence fuelling the compulsive cycle.

42
Q

How are eating disorders best conceptualised?

A

Eating disorders fen be conceptualised as means of reducing intense distress, particularly that associated with feeling everything is out of control.

43
Q

What is psychosis?

A

This is an umbrella term for the collection of symptoms that people present with due to many different reasons. These symptoms include: hallucinations, delusions and/or thought disorder. Essentially psychosis is reality failure as the brain is no longer able to process reality. So it is best defined as a group of pathologies which disrupt the process of perceiving and interpreting reality.

44
Q

What may cause psychosis?

A

1) Delirium - acute brain failure:
> Clouding of consciousness
> Attention deficit
2) Encephalopathy, acquired brain injury, stroke, etc.
3) Dementia
> Alzheimer’s
> Vascular
> Parkinson’s/ Lewy Body
> Huntington’s
4) Personality disorder - parapsychotic phenomena (e.g. hearing the vice of those who abused them).
5) Schizophrenia (“true psychosis)
6) Mania, depression, schizoaffective disorder, puerperal psychosis
(associated with giving birth) and other psychotic disorders
7) Drugs
> Cocaine, LSD, cannabis and alcohol
> L-Dopa, steroids and anticholinergics
8) Metabolic
> Ca2+, Mg2+, Cu2+ and Vitamin B12
9) Endocrine
> Thyroid, Cushing’s and Addison’s
10) Infections
> Encephalitis, syphilis

45
Q

What is reality failure?

A

Psychosis usually defined as hallucinations and delusions. However, as the major CNS is to accurately perceive and interpret information about the outside world, these two seemingly discrete symptoms actually describe quite an overarching and nonspecific deficit. So, psychosis represents a large group of different disease processes which are grouped together purely because they all share an end result which looks broadly similar.

46
Q

What is consciousness?

A

1) Consciousness is probably modular, not unitary
> Parallel processing – battery of unconscious processes.
2) Content of conscious awareness is selected by attention
> Both active/voluntary, and passive (salience and automatic screening of irrelevant stimuli)

47
Q

What are auditory verbal hallucinations?

A

These are thoughts/internal monologue experienced as external/other. These are experienced by around 5% of a healthy population.

48
Q

What are delusions?

A

These are fixed, false, unshakeable beliefs, out of context with cultural background.

49
Q

What are the “positive symptoms” of schizophrenia?

A

These are “positive” as they’re added on to the normal human experience, a they include:
1) Hallucinations
2) Delusions - can either persecutors or grandiose
> Delusional perceptions
> Delusions of control
> Thought delusions or interference

50
Q

What are the “negative symptoms” of schizophrenia?

A

1) Anhedonia - loss of enjoyment
2) Apathy
3) Social withdrawal
4) Blunted mood

51
Q

What are the “disorganised symptoms” of schizophrenia?

A

1) Thought disorder
2) Disorganised speech/behaviour
3) Inappropriate affect - incongruity of mood

52
Q

What are the disturbances in the fundamental components of experience/self-awareness associated with schizophrenia?

A

1) Perplexity:
> Disruption of language/meaning
> Aberrantly salient experiences
> Overwhelmed by formless sense of Something Fishy Going On
2) Disruption of the sense of Self
> Thoughts/experiences lose their “mine-ness”
> Internal world (mind/body) spills into external world
> The Other intrudes into internal world

53
Q

Outline the neurobiology begins schizophrenia

A

1) Schizophrenia has a significant genetic component
> Prevalence ~1% & Heritability ~80%
> Heritability from a single parent ~10%, both parents ~50%, ~40% in monozygotic twins.
> More than 200 genes Multifactorial (epi)genetic causes most common; very few single gene causes
> Genes for D2, neurodevelopment and inflammation
2) Excess of striatal dopamine (seen in PET scans)
> Especially in response to stress
3) Abnormal organisation of Default Mode Network
> stimulus-independent thought and self-reflection

54
Q

What is the function of dopamine?

A

1) Anticipated reward leads to directed attention
2) Reward prediction error signalling
3) Salience (sense of importance attached to perceptions)

55
Q

What is working memory?

A

Preconscious working memory stores large amount of data and allows one to contextualise the present moment. Deficits in working memory lead to thought and perception losing context, flow and order.

56
Q

What causes psychosis?

A

1) Genetic component
> Genes predisposing to schizophrenia must also confer significant advantage [more flexible grasp of reality??]
2) Developmental adversity/abuse
> Biased cognitive schemas
> Sensitised striatal dopaminergic system
> High expressed emotion, “double-bind” family dynamic
3) Neurodevelopment
> Prematurity, hypoxia, infection, winter / spring births
4) Life stressors
> Stress-Vulnerability Model
5) Relationship with recreational drugs
> Around 25% of psychosis symptoms

57
Q

How is psychosis/schizophrenia treated?

A

Psychosis is a biopsychosocial illness and so is treatable, using:
1) Antipsychotics
> Antidopaminergic (also serotonergic, anticholinergic, antihistaminergic, etc)
> “Typical” and “Atypical”
2) Psychological therapies
> CBT for Psychosis
> Avatar therapy (just real enough to be immersive)
> Sense of agency over voices
3) Social support
> Supportive environments, structures and routines
> Housing, benefits
> Support with budgeting /employment

58
Q

What are dopamine blockades?

A

These are medications used to treat psychosis that function by blocking the cerebrum (cortical and limbic) pathways. However, the striatum and pituitary pathways can also be accidentally blocked, leading to side effects such as:

1) Neurological (EPSE, tardive dyskinesia, parkinsonism, dystonia, sedation)
2) Prolactin (amenorrhoea, erectile dysfunction, gynaecomastia)
3) Metabolic (diabetes, weight gain)
4) GI (increased appetite, constipation)
5) Muscarinic (hypersalivation)
6) Haematological (neutropenia, agranulocytosis - especially clozapine)
7) Cardiac (arrhythmias, tachycardia, prolonged QTc)
8) Sedation

59
Q

Outline the link between mental illness and violence

A

1) People with mental illness are much more likely to be victims, rather than the perpetrators of violence
2) The rates of violence only higher in a few specific groups
> Schizophrenia (untreated + comorbid substance use) increases the rate of violence by 2-4 times.
> Alcohol abuse increases the rate of violence by 10-20 times.