Psychiatry Flashcards
What are the main methods by which antidepressants work ?
Increasing synaptic availability of N-AD/ Serotonin (5HT)
How do SSRI Works?
SSRIs work by increasing serotonin levels in the brain.
SSRIs inhibit serotonin reuptake by nerve cells so more serotonin is available to pass further messages between nearby nerve cells.
Name some SSRIs?
Effective For Sadness Panic Compulsions
escitalopram fluoxetine sertraline paroxetine citalopram fluvoxamine
Non-pharmacological Tx for depression?
Exercise Counselling Meditation- Yoga, Tai Chi Social Clubs Psychotherapy
Therapy is know to be as effective as anti-depressants in mild/moderate depression.
Common Side effects of anti-depressants?
Hyponatremia GI disturbance Insomnia Sexual dysfunction Weight gain Dry mouth Headaches Agitation/Restlesness/Anxiety
Causes for violent behaviour?
Psychiatric illness, substance misuse, personality disorder, physical illness
Adverse environments
What environmental changes may trigger violence in patients
Overcrowding Noise Alienation Claustrophobia Removal of privileges - due to bad behaviour
Define rapid tranqulisation?
Use of medication in controlling behaviour. Used as a last resort
Examples of antipsychotics
Haloperidol Olazapine Quetiapine Aripiprazole Risperidone Clozapine
What are the 3 Major criteria points for a depression diagnosis?
Time period for the criteria?
Persistent sadness or low mood; and/or
Loss of interests or pleasure (Anehdonia)
Fatigue or low energy (Anergia)
At least 1 of these, most days, most of the time for at least 2 weeks.
DSM-V
<5- SUBTHRESHOLD DEPRESSION
> 5 SIGECAPS + ONGOING FOR 2 WEEKS (MOST DAYS)
Symptoms of depression?
Time period?
Sleep Appetite Concentration Low confidence Suicidality Agitation Slowing of movements Guilt
Symptoms should be present for a month or more and every symptom should be present for most of every day.
What area of the brain deals with initiating muscle contractions?
Basal ganglia
What should you consider when doing a Mental State Examination?
Appearance Speech Memory/mood Thoughts Perception Orientation
Always Send Mail Through Post Office
MSE - Appearance
What things do you think about?
- Eye contact and rapport
- Clothing
- Hygiene
- Facial expressions
- Motor behaviours
- Signs of autonomic arousal
- Affect
Define Affect?
How people convey their mood by their behaviour
e.g. reactive and appropriate - that is, laughs at a joke, or cries when sad.
MSE - Speech
What things do you think about?
Content
Volume
Form - Speech rate, rhythm, fluency of speech
MSE - Mood
What things do you think about?
Elevated / Depressed?
Ask the patient to describe their mood subjectively?
Enquire about other mood states such as anxiety and panic?
MSE - Perceptions
What things do you think about?
Hallucinations? - Type/Origin
Delusions?
Define Delusion?
“A delusion is a false, unshakeable idea or belief which is out of keeping with the patient’s educational, cultural and social background; it is held with extraordinary conviction and subjective certainty.”
MSE - Orientation/Cognition
What things do you think about?
Orientation- time, person and place
General knowledge - name of prime minister, recent news items etc.
Concentration and attention? - Spelling WORLD backwards or serial sevens
Recall - repeating the new information five minutes later
Registrations - ability to repeat new information such as a name and
address
What’s the lifetime prevalence of mental illness?
25%
1 - What are the common types of mental disorder (6) ?
2 - Which is the most common?
1 - Affective disorders, dementia, psychoses, substance misuse, personality disorder, anxiety disorders (panic/OCD/PTSD)
2 - Affective (Mood) disorders
- Depression
- Bipolar
What is bipolar depression also known as
Manic Depression
What is mood congruence? Give examples
Symptoms experienced are in agreement with the person’s current mood.
e.g. Feeling suicidal when your dog dies
Believing you have superpowers when you are going through a manic episode
What is mood incongruence? Give examples
Symptoms experienced are conflicting with the person’s current mood.
e.g. Laughing when your dog dies
Believing you have superpowers despite going through a major depressive episode
Define Dysthymia?
Mild chronic depression.
Symptoms are not severe enough to meet criteria for a mild depressive disorder.
What are the the 4 distinctions of depression
Mild, Moderate, Severe,
Psychotic (Delusions/Hallucinations)
- Should be used to classify a single depressive episode.
Further episodes = Recurrent depressive disorder, with an episode of X
Mild - 5 SIGECAPS (At least 1 core) - Minor functional impairment
Moderate - Functional impairment between mild and severe
Severe - Most symptoms present, Severe functional impairment that interferes with normal function +/- psychotic symptoms
What are some differential diagnoses for depression?
Hypothyroidism, Cushing syndrome Dysthymia Cyclothymia Bipolar disorder Schizophrenia GAD PTSD Postnatal depression OCD Eating disorder Bereavement Normal sadness Drugs side effects
Pharmacological treatment options for depression?
Antidepressants - SSRI, TCAs ,MAOi
ECT
CBT
Counselling
What factors affect choosing an antidepressant?
Pregnancy Patient Preference Previous Treatment experience Suicidality Past history of elevated mood Age and Physical Health
On average how much earlier do people with severe mental disorders die vs. gen population?
10-25 years
Understand contributing factors can also lead to premature death -e.g. Co-mobitdities
Generally whose is more likely to have mental health problems
Men or Women?
Women (X2)
Define Personality
Innate and enduring characteristics characteristics of an individual which shapes their attitudes, thoughts and behaviours in response to situations.
What is a personality disorder?
Enduring patterns of thinking and feeling about oneself and others that significantly and adversely affect how and individual functions in various aspects of life.
Characteristics cause difficulties for themselves or relationships with others.
Abnormalities must not be caused by any other condition. Out keeping with social & cultural norms.
What are the 3 classifications for personality disorders?
Cluster A - Odd/Eccentric
Cluster B - Dramatic, Emotional & Erratic
Cluster C - Fearful & Anxious
MAD BAD SAD
What the CLUSTER A Personality disorders?
Paranoid
Schizoid
Schizotypical
What the CLUSTER B Personality disorders?
Histrionic Narcissistic Antisocial (dissocial) Emotionally Unstable Borderline Emotionally Unstable Impulsive
What the CLUSTER C Personality disorders?
Avoidant
Dependent
Anankastic (OCD)
Characteristics of Paranoid PD?
Suspicious of others - interprets motives as malevolent
Sensitive
Pervasive distrust
Jealousy (Partners fidelity)
Characteristics of Schizoid PD?
Pattern of detachment from social relationships
Excessive introspection & fantasy
Wants nothing to do with social interaction
Characteristics of Schizotypical PD?
Strange/Odd behaviour
Strange Appearance, belief & thinking
Interpersonal discomfort
NO PSYCHOTIC EPISODE
Characteristics of Antisocial PD?
Violates rights of others/ Callous lack of concern
No respect for authority
Aggression and Irritability
Characteristics of Histrionic PD?
Flamboyant Attention seeking Seductive Excessively emotional / Self-dramatisation Manipulating behaviour Egocentric
Characteristics of Narcissistic PD?
Grandiosity
Lack of empathy
Heighten importance of self
Need for admiration
Characteristics of Borderline PD / EUPD?
Unstable self-image
Unstable relationships
Splitting views of individuals - All good or All Bad
Characteristics of Emotionally Unstable Impulsive PD?
Inability to control anger
Unpredictable affect and behaviour
Characteristics of Anxious/Avoidant PD?
Very timid & shy
Low self-esteem
Avoids social contact - Uncomfortable
Afraid or rejection
Characteristics of Dependent PD?
Passive allow others to direct their lives
Lacks self-confidence
See themselves as hopeless or stupid
Clingy
What is the management for personality disorders?
Pharmacological Intervention
A & B - Antipsychotics
C - Antidepressants
Mood stabilisers - Li or Anticonvulsants to control affective instability or impulsivity
Psychodynamic therapy
DCT
CBT
Substance abuse treatment program referral
Which Personality Cluster has highest rate of suicide or violent deaths
Cluster B
Complications are personality disorders
Substance misuse
Self-Harm and suicide
Depressive disorder
Differentials Personality disorders?
Substance misuse Affective disorders Psychotic disorders Anxiety disorders (Phobia & Panic) Dementia
Characteristics of Anankastic (OCD) PD?
Perfectionist
Preoccupied with trivial details
Inflexible
Feelings of excessive doubt or caution
Investigations for PD?
Clinical Interview
Urine drug screen
MRI/CT scan of brain
Questionairres for differentials - PHQ-9, GAD-7, GAD2, SAPAS(Standardised Assessment of Personality Abbreviated Scale)
What are the main purposes for conducting a suicide risk assessment?
- Establish Patients intent.
- Assess the seriousness and perceived seriousness of attempt.
- How the patient feel about the attempt
Suicide Risk Assessment? - What areas do you need to cover
- Current Episode of self harm - Before Event, During Event, After Event
- Previous Episodes of self-harm
- Screen for Mental health conditions - Depression / Psychosis / Anorexia/ Alcohol Dependency
- Past psychiatric history and remainder of normal history taking- PMH, DH FH, SH
SH Needs to be focused on more!!
Questions MUST ask about self-cutting?
Location of cuts How many cuts? How deep? Feeling when they saw blood? Perceived outcome of cutting? Feelings at moment of cutting?
Questions MUST ask about OD?
Type of medication? How they got medication? How much medication was taken? What did you take with the medication? Perceived outcome of taking the medication? How long have you been planning taking medication? Action after taking medication? How they got to hospital?
Suicide Risk Assessment BEFORE Questions?
Trigger?
Planned or impulsive?
Any Final Acts? Preparative acts - Will, Note, Money transfers etc…
Any precautious steps taken not to be discovered?
Influenced by drugs or alcohol?
Suicide Risk Assessment DURING Questions?
Method? Alone? Location? Actions after self harming? Did they think self-harm would kill them? Thoughts at the time?
Suicide Risk Assessment AFTER Questions?
Did you call anyone?
Currently feel suicidal?
If you were to go home today, what would you do?
Any preventative factors against future self harm?
Willingness for treatment?
What areas of a SH need to be addressed?
Living situation Relationships & Dependants Occupation Drug & Alcohol Use ADLs
Possible Psychosis, Suicide Risk Assessment
What questions should you ask?
Are thoughts to harm ever not your own?
Do you feel that there are voices telling you to self-harm that others cannot hear?
How do they know these voices are not their own worries?
Define Suicide?
Act of intentionally killing oneself with the primary aim of dying
Define attempted suicide?
Act of intentionally killing oneself with the primary aim of dying, but failing to do so.
What is Parasuicide?
Act that looks like suicide but doesn’t result in death as a cry for help, attention, revenge or expression of despair.
What is Deliberate Self Harm?
Deliberate Self Harm (DSH)
Act of intentionally injuring oneself not intended to cause death but to gain relief from psychological stress / pain.
What are sociodenographic risk factors for suicide?
Gender - M>F
Age - 15 -44
Marital status - Single, divorced, widowed
Unemployed
Occupations- Farmers, doctors, Vets, pharmacists
Socioeconomic status- G4 & 5
Poor/no level of social support - elderly, prisoners, refugees
Personal reasons - Abuse as a child, access to means
Sense of hopelessness/feeling of entrapment
What are the clinical factors for suicide?
Hx of DSH
Mental disorder
Physical illness (Chronic) / significant pain.
FH of DSH
What are the 5 Main categories for mental illness?
Mood Disorders Psychosis and Schizophrenia Anxiety Disorders Eating Disorders Dementia
How can all mood disorders be divided?
Primary Mood disorders
Secondary Mood disorders (Organic)
What are the primary mood disorder categories?
Unipolar
Depressive Disorder - Mild, Moderate, Severe, Psychotic
Dysthymia
Bipolar
Bipolar Affective Disorder - B1 & B2
Cyclothymia
Define Primary mood disorder?
A mood disorder that doesn’t result from another medical or psychiatric condition
Define secondary mood disorder?
Mood disorder that results from another medical or psychiatric condition - e.g. anaemia, hypothyroidism, substance missuse
What criteria must be met for a mood disorder to be classed as bipolar?
MUST HAVE HAD 1 OR MORE EPISODES OF MANIA OR HYPOMANIA
What is recurrent depressive disorder?
A patient that has had more than one episode of depressive disorder.
Current episode - classified for a single episode
Define Bipolar 1?
Episodes of major depression and mania
- Full blown mania lasting at least 7 days
- Major depression at least 2 weeks
- Symptoms of mania severe enough that hospitalisation is required
Define Biopolar 2?
Episodes of major depression and hypomania
-No full blown manic or mixed episodes (No history)
Define Cyclothymia?
Recurrent episodes of mild elation and mild depressive symptoms that aren’t sufficiently severe or prolonged to meet criteria for BPD
Hypomanic and depressive symptoms don’t meet B2 Criteria
“Mild chronic bipolar affective disorder. “
Aetiology behind mood disorders?
Genetics
Change in neurorecptors functions
Neurochemical imbalances - Depletion of nAd, serotonin, dopamine
Organic causes
Environmental factors - Life events
Neurological abnormalities - loss of volume in frontal and temporal lobes
What effect does cocaine and amphetamines have?
Increases the levels of monoamines in synaptic cleft + elevates mood.
What are organic causes?
Neurological, Endocrine, Metabolic, Neoplastic, Drugs
What blood level is lithium toxicity considered
> 1.5 mmol/L
Name a fast acing sedative used in highly agitated and difficult to manage individuals
Lorazepam
Name some anticonvulsants
Lamotrigine, Carbamazepine, Valproate
Define psychomotor retardation
Slowing down of thought
Reduction of physical movements in an individual
Can be visible and be observed in speech and affect.
What are the 5 principles of the mental capacity act
- ASSUME a person has CAPACITY unless proved otherwise.
- Don’t treat people as incapable of making unless ALL PRACTICABLE STEPS have been been taken to help make a decision
- Don’t treat a person as unable to make a decision just because they seem to make an UNWISE DECISION
- Always take decisions in THE BEST INTERESTS of a person who lacks capacity
- Before making a decision consider if the act can be acheived in a LEAST RESTRICTIVE way of a persons right and freedom of action
What requirements must a person with capacity meet to make a decision?
- UNDERSTAND information RELEVANT to the decision
- RETAIN information for a sufficient period to make decisions.
- Use & WEIGH UP information as part of a process of making the decision
- COMMUNICATE their decision
What are the two types of sensory deceptions
Hallucinations
Illusions
What are the 4 disorders of thought?
Stream of thought
Possession of thought
Content of thought
Form of thought
Define Anxiety
State of psychological and physical symptoms brought about by a sense of apprehension at a perceived threat.
Causes of anxiety disorders
Genetic factors
Neurochemical abnormalities - GABA inbalance
Environmental factors - Stressful events
Describe the steps in the cognitive behaviour model for panic disorders
- Initial trigger + Risk factors leads to
- Fearful thoughts
- Emotions of fear and anxiety
- Body fight and flight system kicks in
- Symptoms of anxiety occur
4a. Behavioural changes are taken to avoid panic.
What are the treatment options for panic disorders
TCAs, SSRI, CBT, Benzodiazepines.
Describe the characteristics of a panic attack
Describe the features on cognition, behaviour and anxiety occurrence for panic disorders
Rapid onset of severe anxiety, lasts 20-30 minutes.
Associated cognitions- Fear of symptoms
Anxiety occurrence - Episodic (Occur recurrently and unexpectedly)
Associated behaviour- Escape
What lasting complications can arise from panic attacks
Secondary Agoraphobia
-Panic attack makes person avoidant of leaving the house to reduce risk of having a panic attack
What is generalised anxiety disorder
Persistent and excessive worry about a number of activities or events. (>- 6M, Most days)
Uncontrollable and irrational worry
Anxiety and worry are associated with symptoms (3+)
It is neither situational or episodic. (Phobia, Panic Disorder)
What are the symptoms associated with GAD? (6)
Concentration difficulty Restlessness Irritability Muscle tension Sleep disturbance (Falling asleep, staying asleep) Being easily fatigued
What diagnostic tool is used for Generalised anxiety disorder?
GAD-7
Name First Rank Symptoms (Schneiders)?
Auditory hallucinations - Thought echo, 2nd Person, 3rd person, voices arguing or commenting.
Thought Allienation (X3) -Thought Withdrawal, insertion, broadcasting
Somatic passivity
Delusional perception
Made feelings, impulses or actions (volition, affect, impulse)
Define Delusional perception?
Attribution of a new meaning usually in sense of self reference to a normally perceived object
Combines memory+ delusional significance
e.g. person thinks he’s from royal decscent because he remembers a spoon as boy that had a crown on it.
Define Passivity?
Belief that one’s thoughts or actions are influenced or controlled by an external agent.
What is the DSM-5 Criteria for BRIEF PSYCHOTIC EPISODE?
At Least 1: Delusions, Hallucinations or disorganised speech
Time period: >24H but LESS THAN 30 days
n.b. - good consideration when considering a differential of delirium
Define Delirium
Neuropsychiatric syndrome
A sudden state of severe confusion and rapid changes in brain function and mental abilities.
In what circumstances should Benzodiazepines be used?
Alcohol/benzo withdrawal
suspected catatonia
C/I to antipsychotics and extremely agitated
NOTE- Can make delirium worse
Define Psychosis?
A symptom or feature of mental illness characterised by radical changes in personality, impaired functioning, and a distorted or nonexistent sense of objective reality.
Person loses contact with reality.
Loss of function
Lack on insight
What are the main symptoms of psychosis?
Hallucinations
Delusions
Confused and disturbed thoughts
What are the investigations for psychosis?
Rule out organic causes - FBC, UE, Urine drug screen, LFTs, Kidney function, Glucose, Folate & Vitamin B Levels (12,1,3), TFTs, Blood culture
ESR, ANA - (Autoimmune)
What are the treatments for psychosis?
Biological
Psychological
Social
Define Hallucination?
A false sensory perception experienced without external stimulus.
Types of hallucinations?
Auditory - False perceptions of sound
Visual - False visual perceptions of sound
Tactile - False perceptions of touch (Formication)
Gustatory - False perceptions of taste
Olfactory - False perceptions of smell
Mneumonic for TCA Side Effects
Can’t see - Blurred vision
Can’t pee - Urinary retention
Can’t spit - Dry mouth
Can’t shit - Constipation
Risk Factors for interaction with perinatal psychiatry?
Perinatal - During Pregnancy up to 1 year postpartum
Low socioeconomic status Lone Parent Teenage pregnancy Unwanted pregnancy Low social support Poor family relationships
Main conditions associated with perinatal psych?
Postnatum depression Baby Blues Postpartum (puerperal) psychosis Perinatal OCD Perinatal PTSD
What is Anorexia Nervosa? (AN)
Eating disorder chartered by restriction of caloric intake leading to:
Low body weight
Intense fear of gaining weight
Body image disturbance
What is key distinction between Bulimia Nervosa vs. AN
BMI
BN >21
AN<18.5 (15%+ below expected)
BN - Normal/Overweight
AN- Underweight
Treatment for AN?
- Structured eating plan with oral nutrition
- Psychotherapy - AN Family therapy
- Fluid Repletion of any loss electrolytes-K, Ca2, Mg2+, Na,
+- SSRI Depression (Fluoxetine)
In extreme cases - NG feeding, oral feeding. Feeding as a treatment for MHA assessment
Education on nutrition to challenge over-valued ideas.
Investigations for AN?
CBC UE LFTs - UP ALT, AST TFTs - Low T3 Urinalysis ECG
Possible additionals - Hormone levels (Test, estradiol), Bone density
What can cause Metabolic alkalosis & Hypokalemia results.
Vomiting
Why is early intervention important in AN?
Prevents long term psychiatric and physical complications of AN