Psychiatry Flashcards

1
Q

Third person auditory hallucinations

A

Schizophrenia

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2
Q

Mesocortical dopamine hypoactivity

A

Negative/cognitive symptoms of schizophrenia

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3
Q

Subcortical dopamine hyperactivity

A

Psychosis

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4
Q

What is the function of the tuberoinfundibular dopamine pathway

A

Prolactin release

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5
Q

What is the function of the nigrostriatal dopamine pathway

A

Extrapyramidal motor function

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6
Q

What is the function of the mesocortical and subcortical dopamine pathways - what are these known as when combined?

A

Motivation and reward / mesolimbic system

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7
Q

Which dopamine pathway(s) are dysregulated in schizophrenia?

A

Subcortical and mesocortical (mesolimbic)

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8
Q

Mesolimbic dopamine blockade leads to what

A

Depression

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9
Q

Mesolimbic dopamine agonism leads to what

A

Psychosis

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10
Q

Anti-psychotic causing weight gain

A

Olanzapine

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11
Q

Main side effects of clozapine

A

Agranulocytosis and weight gain

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12
Q

What needs to be done before prescribing clozapine

A

Have tried two other anti-psychotics

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13
Q

Who can prescribe clozapine

A

Only consultant psychiatrist

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14
Q

Describe the monitoring of clozapine

A

Every week for 6 months, every 2 weeks for the next 6 months and then monthly thereafter (also one month after discontinuation)

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15
Q

What are the brain changes seen in schizophrenia

A

Reduced frontal lobe volume, enlarged lateral ventricles, reduced grey matter in the temporal cortex

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16
Q

Pressure of thought (2)

A

Mostly mania, can be seen in psychosis

17
Q

Thought blocking

A

Schizophrenia

18
Q

Flight of ideas

A

Mania

19
Q

How to treat EPSEs

A

Procyclidine

20
Q

Brain structure involved in the normal response to threat

A

Amygdala

21
Q

What is Beck’s triad

A

Negative feelings about the self, world and future

22
Q

What happens after taking NMDA antagonists

A

Psychotic symptoma

23
Q

Drug used for alcohol withdrawal

A

Chlordiazepoxide

24
Q

Seizures as a result of alcohol withdrawal occur within how long

A

48 hours

25
Q

Delirium tremens occurs within how long of alcohol withdrawal

A

48-72 hours

26
Q

Eosinophilic inclusions

A

Lewy bodies