Psychiatry Flashcards
What are the core features/symptoms of depression?
Low mood
Anergia
Anhedonia
List aetiology/risk factors for depression
Genetics, family history Stressful events/life Alcohol/drug use Chronic disease Steroid use, Cushing's syndrome (HPA disruption)
List additional symptoms and signs of depression (not core features)
Negative thoughts and speech Insomnia, early morning wakening Reduced appetite Weight loss Loss of libido Inattention, poor concentration Thought poverty, low pressure of speech Reduced facial expressions Limited body language
What is the criteria for mild-mod depression?
2/3 core symptoms + 4 additional symptoms
What is the criteria for severe depression?
3/3 core symptoms + 5 additional symptoms
What investigations would you order for suspected depression?
Largely clinical diagnosis based on history and mental state
Thyroid function test
Inflammatory markers
CT/MRI brain
List drug classes and examples of drugs used in depression
SSRI (fluoxetine, citalopram, sertraline, paroxetine)
TCA (amitryptiline, clomipramine, imipramine)
MAOi (phenelzine, moclobemide)
SNRI (venlafaxine, duloxetine)
NASSA (mirtazepine)
Anticonvulsants/mood stabilisers (lamotrigine, lithium, sodium valproate)
What are some notable side effects of SSRI?
GI upset
Short-term anxiety/suicidal ideation
Sexual dysfunction
Hyponatraemia
What are some notable side effects of TCA?
Sedation
Anticholinergic side effects (dry mouth, dizziness, blurred vision, urinary retention, constipation)
What are some notable side effects of MAOi?
Hypertensive crisis Postural hypotension Drowsiness Insomnia Nausea, constipation Reaction with tyramine foods
What factors influence suicidal thoughts/intent/behaviour?
Male Older Living alone Recent traumatic event Unemployment, financial struggle Major psych illness Alcohol/drugs addiction Family problems
What factors influence self harm?
Female Young Social issues Personality disorder Alcohol abuse Arguments Stress Child abuse
Define bipolar disorder
2 or more episodes of mood and behaviour disturbance involving hypomania/mania and depressive phases
What are the three types/classifications of bipolar disorder?
I: manic episode + previous hypomanic-depressive episodes
II: 2 or more hypomanic-depressive episodes (no mania)
III: drug-induced hypomania-depression
What is the difference in duration between hypomania and mania?
Hypomania lasts 4 consecutive days
Mania lasts 7 consecutive days
List aetiology/risk factors for bipolar disorder
Genetics, family history Infections Hyperthyroidism SLE Stroke Recreational drugs (amphetamines, cocaine, cimetidine, steroids, levodopa)
List clinical features of bipolar disorder
Elated mood, euphoria Usually depression occupies longer phases Overactivity Restlessness Racing thoughts High pressure speech Irritability Grandiose delusions Flight of ideas Inattention, insomnia Increased libido Irresponsible, reckless behaviour Psychosis more associated with mania
Outline treatment of acute mania/hypomania
Antipsychotic (aripiprazole, olanzapine)_
Detention may be necessary
Mood-stabiliser (valproate)
Which drug is used for bipolar disorder treatment?
Lithium
May use lamotrigine/valproate if ineffective/intolerable
List aetiology/risk factors for anorexia nervosa
Genetics, family history Down-regulated HPA Childhood problems EUPD Social/cultural/occupational factors
What are the specific criteria for diagnosing anorexia nervosa?
Body weight less than 85% expected or BMI less than 17.5
Fear of being fat even when underweight
Purging/vomiting behaviour to lose weight
Endocrine disturbance
List clinical features of anorexia
Cold sensitivity Fatigue Impaired cognition Constipation Osteoporosis Dizziness Fullness after eating Autonomic upset Reduced libido, amenorrhoea
What questions would you particularly ask for investigating anorexia?
Sick because you feel full? Control over eating? One stone loss in 3 months? Fat belief when others say you're thin? Food dominates your life? (SCOFF)
What are the specific criteria for diagnosing bulimia nervosa?
BMI less than 17.5
Recurrent binge-eating behaviour
Preoccupation with weight
Purging mechanisms to overcome fatness