Psychiatry Flashcards

1
Q

What are the core features/symptoms of depression?

A

Low mood
Anergia
Anhedonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

List aetiology/risk factors for depression

A
Genetics, family history
Stressful events/life
Alcohol/drug use
Chronic disease
Steroid use, Cushing's syndrome (HPA disruption)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

List additional symptoms and signs of depression (not core features)

A
Negative thoughts and speech
Insomnia, early morning wakening
Reduced appetite
Weight loss
Loss of libido
Inattention, poor concentration
Thought poverty, low pressure of speech
Reduced facial expressions
Limited body language
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the criteria for mild-mod depression?

A

2/3 core symptoms + 4 additional symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the criteria for severe depression?

A

3/3 core symptoms + 5 additional symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What investigations would you order for suspected depression?

A

Largely clinical diagnosis based on history and mental state
Thyroid function test
Inflammatory markers
CT/MRI brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

List drug classes and examples of drugs used in depression

A

SSRI (fluoxetine, citalopram, sertraline, paroxetine)
TCA (amitryptiline, clomipramine, imipramine)
MAOi (phenelzine, moclobemide)
SNRI (venlafaxine, duloxetine)
NASSA (mirtazepine)
Anticonvulsants/mood stabilisers (lamotrigine, lithium, sodium valproate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are some notable side effects of SSRI?

A

GI upset
Short-term anxiety/suicidal ideation
Sexual dysfunction
Hyponatraemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are some notable side effects of TCA?

A

Sedation

Anticholinergic side effects (dry mouth, dizziness, blurred vision, urinary retention, constipation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are some notable side effects of MAOi?

A
Hypertensive crisis
Postural hypotension
Drowsiness
Insomnia
Nausea, constipation
Reaction with tyramine foods
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What factors influence suicidal thoughts/intent/behaviour?

A
Male
Older
Living alone
Recent traumatic event
Unemployment, financial struggle
Major psych illness
Alcohol/drugs addiction
Family problems
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What factors influence self harm?

A
Female
Young
Social issues
Personality disorder
Alcohol abuse
Arguments
Stress
Child abuse
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Define bipolar disorder

A

2 or more episodes of mood and behaviour disturbance involving hypomania/mania and depressive phases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the three types/classifications of bipolar disorder?

A

I: manic episode + previous hypomanic-depressive episodes
II: 2 or more hypomanic-depressive episodes (no mania)
III: drug-induced hypomania-depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the difference in duration between hypomania and mania?

A

Hypomania lasts 4 consecutive days

Mania lasts 7 consecutive days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

List aetiology/risk factors for bipolar disorder

A
Genetics, family history
Infections
Hyperthyroidism
SLE
Stroke
Recreational drugs (amphetamines, cocaine, cimetidine, steroids, levodopa)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

List clinical features of bipolar disorder

A
Elated mood, euphoria
Usually depression occupies longer phases
Overactivity
Restlessness
Racing thoughts
High pressure speech
Irritability
Grandiose delusions
Flight of ideas
Inattention, insomnia
Increased libido
Irresponsible, reckless behaviour
Psychosis more associated with mania
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Outline treatment of acute mania/hypomania

A

Antipsychotic (aripiprazole, olanzapine)_
Detention may be necessary
Mood-stabiliser (valproate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which drug is used for bipolar disorder treatment?

A

Lithium

May use lamotrigine/valproate if ineffective/intolerable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

List aetiology/risk factors for anorexia nervosa

A
Genetics, family history
Down-regulated HPA
Childhood problems
EUPD
Social/cultural/occupational factors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are the specific criteria for diagnosing anorexia nervosa?

A

Body weight less than 85% expected or BMI less than 17.5
Fear of being fat even when underweight
Purging/vomiting behaviour to lose weight
Endocrine disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

List clinical features of anorexia

A
Cold sensitivity
Fatigue
Impaired cognition
Constipation
Osteoporosis
Dizziness
Fullness after eating
Autonomic upset
Reduced libido, amenorrhoea
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What questions would you particularly ask for investigating anorexia?

A
Sick because you feel full?
Control over eating?
One stone loss in 3 months?
Fat belief when others say you're thin?
Food dominates your life?
(SCOFF)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are the specific criteria for diagnosing bulimia nervosa?

A

BMI less than 17.5
Recurrent binge-eating behaviour
Preoccupation with weight
Purging mechanisms to overcome fatness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
List clinical features of bulimia nervosa
``` Storage of food Eating large quantities Vomiting, calluses on hands (Russell's sign) Tetanic muscles Swollen salivary glands Endocrine disturbance ```
26
Outline treatment for eating disorders
``` CBT, family therapy Diet management, food diary Treat complications OCP can boost oestrogen SSRI may help ```
27
List clinical features of generalised anxiety disorder
Psychological: worry, panic, irritability, reduced concentration, restlessness, distractability CNS: numbness, tingling, fatigue, insomnia, dizziness, headache, tremor Autonomic: palpitations, chest pain, hyperventilation, xerostomia, nausea, vomit "lump in throat" "butterflies" "ringing" nail-biting thumb-sucking
28
What is the duration of symptoms for diagnosis of generalised anxiety disorder?
6 months or more
29
Outline non-pharmacological treatment of generalised anxiety disorder
Lifestyle - exercise, relaxation, meditation, avoid caffeine and anxiogens CBT, mindfulness Graded exposure desensitisation Hypnosis
30
Outline pharmacological treatment of generalised anxiety disorder
``` Anxiolytics (diazepam for less than 6 weeks) SSRI (fluoxetine) Pregabalin Paroxetine for social anxiety Venlafaxine ```
31
What is the time criteria for panic disorder?
Panic lasts up to 45 mins and peak anxiety occurs around 10 mins
32
List clinical features of panic disorder
``` Hyperventilation Restlessness Palpitations Sweating Fear, horror Helplessness Numbness Features of GAD ```
33
What is depersonalisation?
Perception that people/self are unreal or automated | e.g. body like cotton wool
34
What is derealisation?
Perception that one is detached from reality
35
What is a phobia?
Irrational fear that is uncontrollable, causing anxiety and avoidant behaviour
36
What is classical vs imagined conditioning with regards to developing phobias?
Classical: fear develops after stimulus caused emotional shock Imagined: fear develops in childhood/development
37
Outline treatment of phobias
Graded exposure desensitisation Flooding (not routinely done) CBT Paroxetine for social phobia
38
What are obsessions and compulsions?
Obsessions are stereotyped, purposeless behaviours that are unwanted Compulsions are repeated rituals that reduce anxiety when performed
39
List clinical features of obsessive compulsive disorder
``` Constant checking Repetitive thoughts and actions Superstitions Perfectionism Anxiety ```
40
Outline treatment of obsessive compulsive disorder
CBT, exposure response therapy SSRI (fluoxetine) TCA (clomipramine) Deep brain stimulation
41
What is post-traumatic stress disorder?
Protracted response to stressful event/trauma, diagnosed 3 months after the event
42
List aetiology/risk factors for PTSD
``` Natural/human disasters, war Accidents Witness death Sexual assault Kidnap ```
43
List clinical features of PTSD
``` Nightmares Flashbacks Insomnia Panic disorder signs become chronic Emotional numbing Detachment Avoidant behaviour Hyperarousal, hypervigilance ```
44
Outline treatment of PTSD
``` Focused psychotherapy, CBT EMDR Correct stress hormone dysregulation SSRI (paroxetine) TCA (amitryptilline) BZD's Venlafaxine ```
45
What is a hallucination?
Perceptual experience that does not match reality
46
What is a delusion?
Fixed firm belief that is illogical and not amenable to change in the face of evidence to the contrary
47
What is schizophrenia?
Psychotic illness involving cognitive and behavioural disturbance
48
What is the proposed pathophysiology of schizophrenia?
Increased dopaminergic neurotransmission and activity
49
List aetiology/risk factors for schizophrenia
Early cannabis use Altered neurobiology and development Abnormal brain architecture Genetics (NRG-1 on c8, dysbindin on c6)
50
List structural brain abnormalities in schizophrenia
Enlarged lateral ventricles Reduced cortical volume, esp frontal lobe Reduced hippocampal volume
51
List clinical features of schizophrenia
Psychosis (hallucinations, delusions, thought disorder) | -ve symptoms (lack of volition, social withdrawal, apathy, self-neglect, blunted mood/affect)
52
Outline treatment for schizophrenia
``` Psychosocial intervention, CBT, family therapy Antipsychotic Acute management (de-escalate, oral/IM haloperidol +/- lorazepam) ```
53
What is the ICD-10 criteria for dependence?
``` Strong desire for the substance Difficulty controlling use of substance Physiological withdrawal state Neglect other pleasure Persist with substance despite evidence of harm ```
54
List aetiology/risk factors for drug dependence
``` Difficult social circumstances Inherited vulnerability Unemployment Depression, anxiety, PTSD Childhood abuse ```
55
Give examples of stimulants
``` Amphetamine Mephedrone Phencyclidine Cocaine MDMA ```
56
Give examples of hallucinogens
``` Cannabis Solvents LSD Mescaline Ketamine ```
57
Give examples of depressants
``` Heroin Morphine Codeine Dihydrocodeine Methadone Benzodiazepines ```
58
List clinical features of drug dependence
``` Disturbed cognition Altered consciousness and perception Dangerous/odd behaviour Arrests for larceny Injection site abscesses/infection Requests for drugs Withdrawal symptoms ```
59
Outline treatment for opiate dependence
Detox: methadone, bruprenorphine Maintenance: lofexidine Relapse prevention: naltrexone, acamprosate Psychotherapy
60
Describe risky and high risk alcohol consumption
Risky: 15-35 u/week regularly | High risk: more than 35 u/week regularly
61
List clinical features of alcohol dependence
``` Life revolves around drink Restlessness Irritability, sweaty Jaundice Memory impairment Neuropathy Fits, falls Hallucination Bleeding (varices, MW tears) Anaemia Arrhythmias Hypertension Withdrawal/delirium tremens ```
62
List clinical features of delirium tremens
``` Tachycardia Hypotension Tremor Fits Hallucinations Aggressiveness, violence ```
63
How can CAGE or TWEAC be used to identify alcohol dependence?
Cut-down prompts? Awareness? Guilty about drinking? Eye-opener in the morning? Tolerance? Worry? Eye-openers? Amnesia? Cut-down attempts?
64
Outline treatment of delirium tremens/alcohol withdrawal
Parenteral thiamine Oral diazepam/chlordiazepoxide Prophylaxis - B blocker, carbamazepine, phenytoin
65
Outline treatment of alcohol dependence
Psychotherapy, CBT, AA meetings Relapse prevention (naltrexone) Post-detox abstinence, acamprosate
66
What is personality disorder?
When personality is abnormal/deviates from social or cultural norm and causes harm to self and/or others
67
Describe paranoid personality disorder and give an example of someone from Harry Potter who fits the description
Distrust of others and their motives, constantly suspicious and reluctant to confide or share info Mad Eye Moody
68
Describe schizoid personality disorder and give an example of someone from Harry Potter who fits the description
Detached from social relationships and restricted range of emotion Severus Snape
69
Describe histrionic personality disorder and give an example of someone from Harry Potter who fits the description
Excessive emotionality and attention-seeking behaviour | Draco Malfoy
70
Describe antisocial personality disorder and give an example of someone from Harry Potter who fits the description
Disregard for rights and health of others with lack of remorse for others' feelings Bellatrix Lestrange
71
Describe emotionally unstable personality disorder and give an example of someone from Harry Potter who fits the description
Pattern of unstable relationships, self-esteem with fluctuating mood Lavender Brown
72
Describe narcissistic personality disorder and give an example of someone from Harry Potter who fits the description
Inflated sense of self-importance with deep need for admiration, often with underlying fragile self-esteem Luscious Malfoy
73
Describe avoidant personality disorder and give an example of someone from Harry Potter who fits the description
Social inhibition and feelings of personal inadequacy | Neville Longbottom
74
Describe dependent personality disorder and give an example of someone from Harry Potter who fits the description
Need to be in care or with people, leading to clinging/submissive behaviour Ron Weasley
75
Describe obsessive personality disorder and give an example of someone from Harry Potter who fits the description
Preoccupation with perfection and orderliness with little flexibility Dolores Umbridge
76
What is delirium?
Acute confusional state with cognitive impairment and fluctuating course
77
List aetiology/risk factors for delirium
``` Elderly in hospital Head injury Infection Alcohol excess, withdrawal Sleep deprivation Unfamiliar environment Surgery Drugs (BZD, opioids, anticonvulsants, digoxin, levodopa, illicit drugs) ```
78
List clinical features of delirium
``` Inattention Abnormal perception and mood Worse at night Impaired memory Incoherent speech Hallucinations Fear, terror ```
79
What tool is used to assess delirium?
4AT (Alertness, Attention, AMT4 (age, dob, place, year), Acute onset)
80
Outline treatment of delirium
Treat underlying cause Optimise environment and review drugs Haloperidol/risperidone if severe (oral/IM) BZD if alcohol withdrawal
81
What is the IQ cut-off for mild learning disability? What would you notice in the patient?
IQ between 50 and 70 | Useful development of language, LD noticed in school
82
What is the IQ cut-off for moderate learning disability? What would you notice in the patient?
IQ between 35 and 49 | Most can talk and get by but basic function
83
What is the IQ cut-off for severe learning disability? What would you notice in the patient?
IQ between 20 and 34 | Limited social activity
84
What is the IQ cut-off for profound learning disability? What would you notice in the patient?
IQ less than 20 | Simple speech is difficult, need special counselling and schooling
85
List aetiology/risk factors for learning disability
Brain trauma Antenatal trouble (infection, alcohol, hypoxia, hypothyroidism) Genetics (Down's, fragile X)
86
List clinical features of learning disability
``` Sensory/motor disability Epilepsy Incontinence Below expected intellect, struggle at school Abnormal behaviour in public ```
87
Outline management of learning disability
Speech and language therapy Support nutrition, care, learning, social areas Antipsychotic may lower seizure threshold Behavioural therapy
88
What is attention deficit hyperactivity disorder (ADHD)?
Behavioural disorder incorporating triad of inattention, hyperactivity and impulsive behaviour
89
List aetiology/risk factors for ADHD
Reduced frontal lobe function Premature birth Genetics Smoking/alcohol during pregnancy
90
List clinical features of ADHD
``` Unable to focus/listen to detail Unable to follow instructions or finish tasks Restlessness Disorganised Forgetfulness Insomnia Mood disorder Family stress ```
91
Outline management of ADHD
``` Cognitive and behavioural therapy Parental education School support Stimulant drugs (methylphenidate (Ritalin) or dexamfetamine) Atomoxetine Antidepressant TCA Antipsychotic ```
92
What is autism spectrum disorder?
Lifelong developmental disorder affecting social interaction, communication and behaviour
93
List clinical features of social interaction in autism
Unaware of feelings/existence of others (treat people like furniture) Abnormal response to hurt Impaired imitation Lack of empathy
94
List clinical features of communication in autism
``` Limited facial expressions and gestures Avoids gaze No social smiles or babbling in infancy Stiffens when held, doesn't like to be hugged Lack of speech No interest in stories or fantasy play Repetitive speech Doesn't pick up on social cues/sarcasm ```
95
List clinical features of behaviour in autism
``` Stereotypical movements Preoccupied with parts of objects Inflexible thoughts Distress over changes in environment Routine Precision, fixative behaviour ```
96
What is the criteria for diagnosing autism?
6 or more symptoms, including 2 from social interaction, 1 from behaviour, 1 from communication