Psychiatry Flashcards
Alogia
impoverished speech
Avolition
lack of desire drive or motivation to pursue meaningful goal
Avnhendonia
inaility to experience pleasure from normally pleasurable life events
Negative schizophrenia symptoms
- memory and concentration
- unusual behaviour
- impaired communication
- social withdrawal
- decrease interest w/ daily activity
types of schizophrenia
Paranoid schiz Hebephrenic schiz catatonic schiz undifferentiated schiz post schiz depressiion residual schiz simple schiz
Schneider 1st rank symptoms
auditory hallucination
somatic passivity
delusion of passivity
delusion of perception
Schneider 2nd rank symptoms
2nd hallucionation
2nd delusions
visual tactile olfacory and gestatory hallucination
perplexity (inabilit to deal/ understand something)
emotional blunting
type 1 schizophenia
- ACUTE
- POSITIVE symptoms
- functioned well before the symptoms
- DUE TO: dopamine transmission problem
- no neuro signs
- good cognition
- response well to antipyschiotics
good prognosis
type 2 schizophrenia
- CHRONIC
- NEGATIVE symptoms
- hx of poor social and education prior to it
- DUE TO: structural brain abnormalities (CT - Dx)
- neuro signs
- impairment of cognition
- response poor to antipyschiotics
- poor prognosis
dopmine abnormalities in schiz
INCREASE dopamine release in mesolimbic stratum during lines
- correlates to positive symp and good prognosis
DECREASE in mesocortical system
- correlates with defective cognition
DDX of negative schiz symptoms
Depression
effects of neuroleptic meds
environmental under stimulation
physical illness (endocrine/ alzeihmers)
substance misuse
Schizoid or schizotypical personality disorder
autism / asperfer’s syndrome
Ambivalence
simutaneous contradictory thinking (angle and devil)
bleuler - four As of schizophrenia
Ambivalence
Autism (internal simuli)
inappropiate affect
loosening of association
epidemiology of schiz by sex and age
Males = 22 years
feamles = 26
MALES > female
Susceptibility genes and chromosomal abnormalities
Genes
- DAOA - dopamine amino acid oxidase activator
- dysbindin
- neuroregulin
- zinc finger protein 804A
Chromosomes
- DISC1 - disrupted in schizophrenia 1
- microdelition of chrom 22q11 (vela-cranial facial syndrome)
what season is schiz more common
babies born in spring and winter
NH: january - April
SH: Julyl - september
serotonin level in schizophrenia
INCREEASED
left handedness
increase risk of SCHIZOPHRENIA
why does cannibis increase schizophrenia
COMT gene moderates the influence of cannibis use on developing psychosis
brain abnormalities in schizophrenia
Ventricles larger >brain tissue
GREY matter loss > white
TEMPORAL lobe - esp. medial temporal lobe
why are males at greater risk of schizophrnia
Males: - increase obstetric problems - worse premorbid adjustment - more structural brian abnormalities negaitive sympto - worse prognosis
risk of suicide in schizophrenic patients
2%
schizohrenia is ass .w/
Smoking
Bipolar disease
schizotypical disorder
eccentric behaviour and anomalies of thinking and affect which resemble those seen in schizophrenia
schizoaffective disorder
episiodic disorger in which both affective and schizophrenic symptoms are prominent within the same episode of the illness preferably spontaneously but at least within a few days of each other
schizoaffective types with best and worse prognosis
best - schizoaffective type w. mania
worse - schizoaffective type w/ depression
ICD10 criteria - how long for symptoms
1 month or more
what is the least likely to be a DDX of negative symptoms of schizophrenia A - cannibis excess 2. enviromental overstimulation 3. Alzehimers disease 4. Depression 4. Aspergers syndrome
- enviromental overstimulation
the prevalence of schizophrenia
1%
tx of tardive dyskinesia
- stop anticholinergic and decrease antipsychotic dose
CHANGE to CLozapine
Tx for dystonia
Anticholinergics
- Procyclidine and biperiden
parkinsonism / psurdoparkinsonism tx
dose reduction
change to atypical
Anticholinergics
- Procyclidine and biperiden
akathisia treatment
decrease dose
switch to atypical
NO effect with Anticholinergics
response to clozapine in resistant tx schizophrenia
30-60%
indications for clozapine
treatment resistant schiz tardive dyskinesia pyschosis in PArkinson Huntington disease resistent mania
Capgras syndrome
illusion of doubles - thinks they are placed by an exact double
- FAMALES >males
Fregoli syndrome
believer person/ object changes their identity and follows patient