Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Psychiatry > DRUGS > Flashcards

DRUGS Flashcards

1
Q

acamprosate

A

NMDA (N MYTL D ASPARTE ) CO AGONIST ( low concentration - activation when receptor activity is low
and high concentration - inhibit activation when active is high

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

AGOMELATINE

A

MT1 and MT2 melantonegic receptor agonist

5HT2a recepter ANTAGONIST

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Apiprazole

A

patiral agonist at D2 and 5HT1A

antagonist to 5HT2 receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

barbituates

A

GABA agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Benzodiazipine

A

GABAa agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Buprenorphine

A

partial agonist at kappa and mu opiod receptors

Antagonist at delta receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Buspirone

A

5HT1a parital agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Bupropion

A

NDRI - noradrenaline and dopamine reuptake inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clonidine

A

alpa 2 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dexamphentamine

A

CNS stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

disulfiram

A

aldehyde dehydrogenase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

flumazenil

A

benzodiazipine antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Lofexidine

A

a2 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

memantine

A

NMDA recetpro antagoinst

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Methadone

A

MU OPIOD AGONIST

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Methylphenidate

A

CNS stimulant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

VARENICLINE

A

a4B2 neuronal nicotinic actylcholine receptor agoinst

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

zopiclone

A

GABA agoinst

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Zolpidem

A

GABA agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

amtriptyline use

A 
D N N M 
Depression 
neuroleptic pain 
Nocturnal eneursis 
Migraine prophylaxis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

nortiptyline

A

D N N
Depression
neuroleptic pain
Nocturnal eneursis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

imitryptiline

A

D N
Depression
Nocturnal eneursis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

clomipramine

A 
OCP D 
Depression 
OCD 
phobia 
catoplexy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

lofepramine

A

depressioon

safest TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
dothiepin
depression | most toxic in overdose
26
SE of TCA
``` anticholingeric SE (dry mouth, constipation, sedation, decrease saliva) histamine (weight gain and sedation Alpha blockage (postural hypertension) Cardiac SE - prolonged QT - arrythmias - Congestive HF - orthostatic hypertension - tacycardia (think Tca causes Tacycardia) ```
27
antichonergic SE
``` dry mouth blurred vision constipation drowsiness sedation hallucinations memory impairment difficulty urinating confusion delirium decreased sweating decreased saliva ```
28
SSRI withdrawal
dizziness headache ataxia agitation insomnia fatigue paratoxine > fluvoxamine > sertraline
29
fluoxetine use
DOA depression OC disorder Anorexia nervosa or bulimia nervosa ``` Strongers t protein binding longest half life active metabolite (norfluoxetine) ```
30
paroxetine
``` DOP GP depression OCD Phobia+ panic GAS PSTD ```
31
fluvoxamine use
Depression | OCD
32
Citalopram
Depression | Panic agraphobia
33
Escitalopram
depression OCD Panic and phobia GAD
34
sertraline
Depression OCD PTSD
35
when do you get serotonin syndrome
within 2-5 days after discontinuation or within a month
36
SSRI side effects
GI - nausea , vomitting GI upset 5HT2 - Agitation, akathisia, anxiety insomnia and sexual dysgunction 5HT3 - GI and headache
37
serotonin syndrome clinical
Rigidity , MYCLONUS, tremors and HYPERreflexia , tremor NEURO - aggitation , confusion, seizure coma death Autonomia - GI upset, HYPER / hypo thermia, MYDRIASIS, tachycardia
38
Treatment of serotonin syndrome
1. gastric lagage and activated charcoal CYPROHeptadine BETA blockers - propanolo and pindolol - useful in reversing some of the NM and autonomic complications benzodiazepine
39
what medications cause hyponatremia
1. diuretics, desmopressin, antiepileptis, antipsychotics, antidepressant, anticancer, NSIADs
40
Treatment of hyponatremia with antidepressants
``` Fluid restrictions antidepressants should be discontinued and a new class antidepressant can be started (SNRI, MAOI ```
41
venlafaxine use
Spression GAD Diabetic neuropathy and chronic pain Urinary stress incontinece
42
Symptoms compare b/w SNRI, Ruboxteine and Bupropion
ALL 3 share - hedache, dizziness , nausea and dry mouth SNRI and Ryboxetine - CONSTIPATION Buprpion- seizures and weight loss - do not give in anorexic patients
43
clinical of SNRI important
both cause HTN | headache, dizziness, nausea dry moth constipation, decal dysfunction and sedation
44
mianserin
Tetracyclin AD Rash and sedation
45
Trazodone
SARI cuases priapism and sedation
46
Mirtazapine
NADRI - causes weight gain and sedation
47
AGOMELATINE
``` MT1 and MT2 H - headache I - insomnia N - nausea D - dizzy S - sweating ``` LIVER - increase liver
48
how to treat hypertensive crises
Alpha blockage w/ phentolamine OR chlorpromazine | clinical - headache, flushing hypertension and rarrely cerebrovascular
49
Moclobeemide
``` MAO - --> reversible inhibitoion of MAO SNAC Sleep disturbance Nausea Agitation Confusion ```
50
lithium use
``` mild to moderate depression BPA disorder Recurrent depression Aggressive behaviour Self mutilating behaviour Steriod induced psychosis ```
51
Lithium teratogenicity ;
ebstein anomaly cardiac failure blue baby syndrome (due to the insuffienct blood flow to the baby)
52
Valproate use
mania depression Rapid cyclic depression DO not give
53
Valporate toxicity
``` Facies NTD Cardiac Skeltal (radial aplasia and thumb aplasia) Spinal IDisability ```
54
SE of valpoate
GI Drowsiness HYPERANNOMNIA Transiet hair loss -then grows back curly thrombocytopenia/ agranuloyctosis / aneamia Liver and pancreatic toxicity weight gain
55
Carbamazapine teratogenicity
NTD cadiac GI
56
Carbamazapine SE
Ataxia Agraulocytosis GI diplopia Dizziness Drosiness aplastic anemia / thrombocytopenia SJS
57
lamotrignene teratogenicity
oral cleft and SJS
58
lamotrigine SE
GI diplopia headache dizziness and SJS
59
what AP cause sedation
COC Clozapine olanzapine Chlopromazine
60
What AP causes photosensitivity
Chlorpromazine - can cause sunburn
61
what AP causes peripheral oedema
olanzapine
62
AP with hyperprolactine
rivistigmine, Amisulpride | Sulpride
63
postual hypotension which AP
adrenergic a1 block clopromazine , clozapine Risperidone and quiietapine
64
HTN with ap
Clozapine ONLY
65
QT prolongation with AP
Pimozide and setindole
66
Reduce seizure threshold
CLOZAPINE
67
2 things only clozapine SE
decrease seizure threshold | HTN
68
Weight gain with which AP
CLOZAPINE olanzapine ? quietapine ? respiradone ? amisulpride
69
dyslipidemia with AP
phenothiazines clozapine and olanzapine
70
increase risk of diabetes with what AP
clozapine and olanzapine
71
NMS clinical
``` Fever Encepahlopathy VITALS enzymes high - CPK and myoglobin Rigidity ``` PLUS 3 - metabolic acidosis automatic leucocytosis
72
treatment of NMS
dantrolene Benzodiazipine ( lorazepam) Bromocriptine (dopamine agonist) Sodium bicarb - to alkainalize the urine
73
why do you die with NMS
``` 20% die due to: - cardiac collapse resp failure myoglobinuria renal failure DIC Arrythmias ```
74
what can cause NMS
1 AP - haloperiodol and fluphenazine 2. lithium 3 AD - SSRI , TCA, MAOI
75
clozapine is used for
``` treatment of resistant schizophrenia tardive dyskinesa Psychosi in parkinson huntington resistant mania ```
76
MOA clozapine
low affinity for D2 Higher for D4 Also D 1,3,5 Affinity for 5HT, alpha 1 and 2 and muscarinic
77
first generation AP
Chlorprommazine promazine trifluropenazine fluphenazine Haloperidol Flupehthixol Zuclopenthixol Sulpride Pimizide
78
2nd gerneation
amisulpride Olanzapine Queitapine Risperidone palperidone Sertindole Clozapine
79
3rd generation
Aripiprazole
80
what group do these belong to Chlorprommazine promazine trifluropenazine fluphenazine
PHENOTHIAZINE
81
what group do these belong to | Haloperidol
Butyrophenone
82
what group do these belong to | Pimizide
DIPHENylbutylpiperidine (think such a long name for the last 1st generation group
83
what group do these belong to Risperidone palperidone
Benzizoxazole
84
what group do these belong to | Sertindole
Phenylindole derivative
85
treatment of tourettes
Haloperidol Clonidine PImizide
86
two types of a2 agonist
Clonidine lofexadine
87
who are TCA contraindicated in
BPH cause can worsen urinary retension
88
what antidepressants can be used in pregnancy
A N I F Amitryiptyline Noratryptiline Imipramine Fluoxetine
89
risk factor of SSRRI in 3rd trimester
persistent pulmonary hypertension in the new born | Agitation and irritability
90
AP okay in prganncy
Clorpromazine trifluoperotine haloperidol olazapine clozapine
91
antidepressants in breast feeding
paroxetine Sertraline and nortriptylune and imitryptiline
92
percentage of women with CPA disorder get postnatal psychosis
25-50%
93
percentage of women who get postnatal psychosis when they have a family history of postnatal psychosis
74%
94
risk factors for PND
Biological - older age, severe baby blues, past history of depression, past depression in other pregnancy (25% of recurrence risk) fam history of depression in pregnancy or postpartum, sensitive to hormonal meilu Psyschosocial - ambibivlance about pregnanyc, single mom, marital instability, adverse life event, bonding difficulties, sleep distrubance late pregnnacy
95
what AP is recommended for breast feeding mom
olanzapine
96
after postnatal psychosis - risk of developing BPA
20%
97
after postnatal psychosis - what is risk of developing it themselves in next pregnancy
57%
98
high or low socioeconomic status is ass. w/ increase risk of postnatal psychosis
HIGH
99
MOA buprenorphine
partial agonist at mu and kappa opioid receptor and an antagonist at delta receptors
100
MOA busperione
5HT1 reuptake inhibitor
101
atomoxetine
norepinephrine receptor inhibitor
102
apipirazole moa
d2 partial agonist
103
restless leg syndrome treatment
TETRABENZINE (serotonin antagoinst)
104
postural hypotension and pipraism SE
A1 antagonist
105
when do you get motor tic and verbal tic
motor tic - 7 years | verbral tic - 11 years

Psychiatry (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions