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Psychiatry > DRUGS > Flashcards

DRUGS Flashcards

1
Q

acamprosate

A

NMDA (N MYTL D ASPARTE ) CO AGONIST ( low concentration - activation when receptor activity is low
and high concentration - inhibit activation when active is high

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2
Q

AGOMELATINE

A

MT1 and MT2 melantonegic receptor agonist

5HT2a recepter ANTAGONIST

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3
Q

Apiprazole

A

patiral agonist at D2 and 5HT1A

antagonist to 5HT2 receptors

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4
Q

barbituates

A

GABA agonist

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5
Q

Benzodiazipine

A

GABAa agonist

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6
Q

Buprenorphine

A

partial agonist at kappa and mu opiod receptors

Antagonist at delta receptors

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7
Q

Buspirone

A

5HT1a parital agonist

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8
Q

Bupropion

A

NDRI - noradrenaline and dopamine reuptake inhibitor

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9
Q

Clonidine

A

alpa 2 agonist

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10
Q

Dexamphentamine

A

CNS stimulant

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11
Q

disulfiram

A

aldehyde dehydrogenase inhibitor

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12
Q

flumazenil

A

benzodiazipine antagonist

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13
Q

Lofexidine

A

a2 agonist

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14
Q

memantine

A

NMDA recetpro antagoinst

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15
Q

Methadone

A

MU OPIOD AGONIST

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16
Q

Methylphenidate

A

CNS stimulant

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17
Q

VARENICLINE

A

a4B2 neuronal nicotinic actylcholine receptor agoinst

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18
Q

zopiclone

A

GABA agoinst

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19
Q

Zolpidem

A

GABA agonist

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20
Q

amtriptyline use

A 
D N N M 
Depression 
neuroleptic pain 
Nocturnal eneursis 
Migraine prophylaxis
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21
Q

nortiptyline

A

D N N
Depression
neuroleptic pain
Nocturnal eneursis

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22
Q

imitryptiline

A

D N
Depression
Nocturnal eneursis

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23
Q

clomipramine

A 
OCP D 
Depression 
OCD 
phobia 
catoplexy
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24
Q

lofepramine

A

depressioon

safest TCA

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25
Q

dothiepin

A

depression

most toxic in overdose

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26
Q

SE of TCA

A 
anticholingeric SE  (dry mouth, constipation, sedation, decrease saliva) 
histamine (weight gain and sedation 
Alpha blockage (postural hypertension) 
Cardiac SE 
- prolonged QT 
- arrythmias 
- Congestive HF 
- orthostatic hypertension 
- tacycardia (think Tca causes Tacycardia)
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27
Q

antichonergic SE

A 
dry mouth
blurred vision
constipation
drowsiness
sedation
hallucinations
memory impairment
difficulty urinating
confusion
delirium
decreased sweating
decreased saliva
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28
Q

SSRI withdrawal

A

dizziness
headache

ataxia
agitation

insomnia
fatigue

paratoxine > fluvoxamine > sertraline

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29
Q

fluoxetine use

A

DOA
depression
OC disorder
Anorexia nervosa or bulimia nervosa

Strongers t protein binding 
longest half life 
active metabolite (norfluoxetine)
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30
Q

paroxetine

A 
DOP GP 
depression 
OCD
Phobia+ panic 
GAS 
PSTD
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31
Q

fluvoxamine use

A

Depression

OCD

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32
Q

Citalopram

A

Depression

Panic agraphobia

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33
Q

Escitalopram

A

depression
OCD
Panic and phobia

GAD

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34
Q

sertraline

A

Depression
OCD
PTSD

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35
Q

when do you get serotonin syndrome

A

within 2-5 days after discontinuation or within a month

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36
Q

SSRI side effects

A

GI - nausea , vomitting GI upset
5HT2 - Agitation, akathisia, anxiety insomnia and sexual dysgunction
5HT3 - GI and headache

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37
Q

serotonin syndrome clinical

A

Rigidity , MYCLONUS, tremors and HYPERreflexia , tremor

NEURO - aggitation , confusion, seizure coma death

Autonomia - GI upset, HYPER / hypo thermia, MYDRIASIS, tachycardia

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38
Q

Treatment of serotonin syndrome

A
  1. gastric lagage and activated charcoal
    CYPROHeptadine
    BETA blockers - propanolo and pindolol - useful in reversing some of the NM and autonomic complications
    benzodiazepine
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39
Q

what medications cause hyponatremia

A
  1. diuretics, desmopressin, antiepileptis, antipsychotics, antidepressant, anticancer, NSIADs
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40
Q

Treatment of hyponatremia with antidepressants

A 
Fluid restrictions 
antidepressants should be discontinued and a new class antidepressant can be started (SNRI, MAOI
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41
Q

venlafaxine use

A

Spression
GAD
Diabetic neuropathy and chronic pain
Urinary stress incontinece

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42
Q

Symptoms compare b/w SNRI, Ruboxteine and Bupropion

A

ALL 3 share
- hedache, dizziness , nausea and dry mouth

SNRI and Ryboxetine - CONSTIPATION

Buprpion- seizures and weight loss
- do not give in anorexic patients

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43
Q

clinical of SNRI important

A

both cause HTN

headache, dizziness, nausea dry moth constipation, decal dysfunction and sedation

44
Q

mianserin

A

Tetracyclin AD

Rash and sedation

45
Q

Trazodone

A

SARI cuases priapism and sedation

46
Q

Mirtazapine

A

NADRI - causes weight gain and sedation

47
Q

AGOMELATINE

A 
MT1 and MT2 
H - headache 
I  - insomnia 
N - nausea 
D - dizzy 
S - sweating

LIVER - increase liver

48
Q

how to treat hypertensive crises

A

Alpha blockage w/ phentolamine OR chlorpromazine

clinical - headache, flushing hypertension and rarrely cerebrovascular

49
Q

Moclobeemide

A 
MAO -  --> reversible inhibitoion of MAO 
SNAC
Sleep disturbance 
Nausea 
Agitation 
Confusion
50
Q

lithium use

A 
mild to moderate depression
BPA disorder 
Recurrent depression 
Aggressive behaviour 
Self mutilating behaviour 
Steriod induced psychosis
51
Q

Lithium teratogenicity ;

A

ebstein anomaly
cardiac failure
blue baby syndrome (due to the insuffienct blood flow to the baby)

52
Q

Valproate use

A

mania
depression
Rapid cyclic depression

DO not give

53
Q

Valporate toxicity

A 
Facies 
NTD 
Cardiac 
Skeltal (radial aplasia and thumb aplasia) 
Spinal 
IDisability
54
Q

SE of valpoate

A

GI

Drowsiness
HYPERANNOMNIA
Transiet hair loss -then grows back curly

thrombocytopenia/ agranuloyctosis / aneamia

Liver and pancreatic toxicity
weight gain

55
Q

Carbamazapine teratogenicity

A

NTD
cadiac
GI

56
Q

Carbamazapine SE

A

Ataxia
Agraulocytosis
GI

diplopia
Dizziness
Drosiness

aplastic anemia / thrombocytopenia

SJS

57
Q

lamotrignene teratogenicity

A

oral cleft and SJS

58
Q

lamotrigine SE

A

GI diplopia headache dizziness and SJS

59
Q

what AP cause sedation

A

COC
Clozapine
olanzapine
Chlopromazine

60
Q

What AP causes photosensitivity

A

Chlorpromazine - can cause sunburn

61
Q

what AP causes peripheral oedema

A

olanzapine

62
Q

AP with hyperprolactine

A

rivistigmine, Amisulpride

Sulpride

63
Q

postual hypotension which AP

A

adrenergic a1 block
clopromazine , clozapine
Risperidone and quiietapine

64
Q

HTN with ap

A

Clozapine ONLY

65
Q

QT prolongation with AP

A

Pimozide and setindole

66
Q

Reduce seizure threshold

A

CLOZAPINE

67
Q

2 things only clozapine SE

A

decrease seizure threshold

HTN

68
Q

Weight gain with which AP

A

CLOZAPINE olanzapine ? quietapine ? respiradone ? amisulpride

69
Q

dyslipidemia with AP

A

phenothiazines clozapine and olanzapine

70
Q

increase risk of diabetes with what AP

A

clozapine and olanzapine

71
Q

NMS clinical

A 
Fever 
Encepahlopathy 
VITALS 
enzymes high - CPK and myoglobin 
Rigidity

PLUS 3
- metabolic acidosis
automatic
leucocytosis

72
Q

treatment of NMS

A

dantrolene
Benzodiazipine ( lorazepam)
Bromocriptine (dopamine agonist)
Sodium bicarb - to alkainalize the urine

73
Q

why do you die with NMS

A 
20% die due to: 
- cardiac collapse 
resp failure 
myoglobinuria 
renal failure 
DIC 
Arrythmias
74
Q

what can cause NMS

A

1 AP - haloperiodol and fluphenazine
2. lithium
3 AD - SSRI , TCA, MAOI

75
Q

clozapine is used for

A 
treatment of resistant schizophrenia 
tardive dyskinesa 
Psychosi in parkinson 
huntington 
resistant mania
76
Q

MOA clozapine

A

low affinity for D2
Higher for D4
Also D 1,3,5

Affinity for 5HT, alpha 1 and 2
and muscarinic

77
Q

first generation AP

A

Chlorprommazine
promazine
trifluropenazine
fluphenazine

Haloperidol

Flupehthixol
Zuclopenthixol

Sulpride

Pimizide

78
Q

2nd gerneation

A

amisulpride

Olanzapine

Queitapine

Risperidone
palperidone

Sertindole

Clozapine

79
Q

3rd generation

A

Aripiprazole

80
Q

what group do these belong to Chlorprommazine
promazine
trifluropenazine
fluphenazine

A

PHENOTHIAZINE

81
Q

what group do these belong to

Haloperidol

A

Butyrophenone

82
Q

what group do these belong to

Pimizide

A

DIPHENylbutylpiperidine (think such a long name for the last 1st generation group

83
Q

what group do these belong to
Risperidone
palperidone

A

Benzizoxazole

84
Q

what group do these belong to

Sertindole

A

Phenylindole derivative

85
Q

treatment of tourettes

A

Haloperidol
Clonidine
PImizide

86
Q

two types of a2 agonist

A

Clonidine lofexadine

87
Q

who are TCA contraindicated in

A

BPH cause can worsen urinary retension

88
Q

what antidepressants can be used in pregnancy

A

A N I F

Amitryiptyline
Noratryptiline
Imipramine
Fluoxetine

89
Q

risk factor of SSRRI in 3rd trimester

A

persistent pulmonary hypertension in the new born

Agitation and irritability

90
Q

AP okay in prganncy

A

Clorpromazine trifluoperotine haloperidol olazapine clozapine

91
Q

antidepressants in breast feeding

A

paroxetine Sertraline and nortriptylune and imitryptiline

92
Q

percentage of women with CPA disorder get postnatal psychosis

A

25-50%

93
Q

percentage of women who get postnatal psychosis when they have a family history of postnatal psychosis

A

74%

94
Q

risk factors for PND

A

Biological
- older age, severe baby blues, past history of depression, past depression in other pregnancy (25% of recurrence risk) fam history of depression in pregnancy or postpartum, sensitive to hormonal meilu

Psyschosocial
- ambibivlance about pregnanyc, single mom, marital instability, adverse life event, bonding difficulties, sleep distrubance late pregnnacy

95
Q

what AP is recommended for breast feeding mom

A

olanzapine

96
Q

after postnatal psychosis - risk of developing BPA

A

20%

97
Q

after postnatal psychosis - what is risk of developing it themselves in next pregnancy

A

57%

98
Q

high or low socioeconomic status is ass. w/ increase risk of postnatal psychosis

A

HIGH

99
Q

MOA buprenorphine

A

partial agonist at mu and kappa opioid receptor and an antagonist at delta receptors

100
Q

MOA busperione

A

5HT1 reuptake inhibitor

101
Q

atomoxetine

A

norepinephrine receptor inhibitor

102
Q

apipirazole moa

A

d2 partial agonist

103
Q

restless leg syndrome treatment

A

TETRABENZINE (serotonin antagoinst)

104
Q

postural hypotension and pipraism SE

A

A1 antagonist

105
Q

when do you get motor tic and verbal tic

A

motor tic - 7 years

verbral tic - 11 years

Psychiatry (7 decks)

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