Psychiatry 2 Flashcards
Clinical features of delusional disorder?
1+ delusions for 1+ months
Other psychotic symptoms are absent or not prominent
Behavior is not obviously odd/bizarre; ability to function apart from delusion’s impact
What are the subtypes of delusional disorder?
Erotomanic, grandiose, jealous, persecutory, somatic
DDx - delusional disorder
- Schizophrenia (other psychotic symptoms present, such as hallucinations, disorganization, negative symptoms + greater functional impairment)
- Personality disorders (paranoid - pervasive pattern of suspiciousness, narcissistic - grandiosity, schizotypal - odd beliefs, but no clear delusions)
Treatment of delusional disorder?
- Antipsychotics
2. CBT
Clinical features of brief psychotic disorder?
Sudden onset of 1+ psychotic symptoms lasting 1+ days, but less than 1 month; full return to function
Excluded if the symptoms are better explained by the effects of a medication or medical illness
Characteristics of personality disorders?
Long-standing patterns of interpersonal problems but no persistent delusions or other psychotic symptoms
Widespread distrust and suspiciousness are characteristic of ___ personality disorder.
Paranoid
Patients with ___ personality disorder exhibit eccentric behavior and odd beliefs or magical thinking; their beliefs are not held with delusional conviction.
Schizotypal
Patients with ___ personality disorder often display pervasive emotionality or the need to be the center of attention.
Histrionic
Medications commonly used to treat acute bipolar depression?
Second-generation antipsychotics (quetiapine and lurasidone) and the anticonvulsant lamotragine
[Lithium, valproate, and combined olanzapine/fluoxetine have also demonstrated efficacy]
Why should antidepressant monotherapy generally be avoided in patients with bipolar I disorder?
Risk of precipitating mania, development of rapid cycling, increased mood cycle frequency
(If necessary, antidepressants should be used in combination with mood stabilizers as these appear to decrease the risk of an anti-depressant-induced switch from depression to mania)
Define rapid cycling.
4+ mood episodes/year
True or false - haloperidol is a first-generation antipsychotic that has not shown efficacy in treating bipolar depression.
True
High-dose glucocorticoids, often given for allergic, inflammatory, or autoimmune conditions, may cause ___, typically during the first week of treatment, but can occur at any time. What other symptoms can it cause?
Glucocorticoid-induced psychosis; manic or depressive symptoms
Symptoms of cannabis use?
Euphoria, perceptual changes, increased appetite, red eyes, slowed reflexes, dizziness, and impaired coordination
What is the core feature of delirium?
Fluctuating cognitive impairment, such as poor attention and disorientation
What are the characteristic features of medication-induced psychotic disorder?
Acute onset of delusions and/or hallucinations that are temporally associated with the use of a new medication
Diagnosis of dementia with Lewy bodies (DLB)?
Dementia plus 2+ of the following: Visual hallucinations Parkinsonism Fluctuating cognition REM sleep behavior disorder
Treatments for dementia with Lewy bodies?
Carbidopa-levodopa (Parkinsonism) Cholineserase inhibitors (eg, rivastigmine; cognitive impairment) Melatonin (REM sleep behavior disorder) [Trial of antipsychotic medication may be indicated in patients with functionally impairing visual hallucinations or delusions]
Why must antipsychotics be prescribed with caution in DLB?
Extreme antipsychotic hypersensitivity of patients with DLB; may cause worsening confusion, parkinsonism, and autonomic dysfunction
Which antipsychotic is known for stronger dopamine receptor antagonism relative to other second-generation antipsychotics?
Risperidone
When antipsychotics are indicated in the treatment of DLB, evidence favors what? What should be avoided entirely?
Low-potency second-generation antipsychotics (eg, quetiapine); first-generation antipsychotics
Diagnosis of schizophreniform disorder?
1+ month, but <6 months, same symptoms as schizophrenia, functional decline not required
Symptoms of schizophrenia (2+): delusions, hallucinations, disorganized speech, grossly disorganized or catatonic behavior, and negative symptoms
Diagnosis of schizophrenia?
6+ months, with 1+ months of active symptoms, can include prodromal and residual periods, requires functional decline
Diagnosis of schizoaffective disorder?
Major depressive or manic episode with concurrent active-phase symptoms of schizophrenia + lifetime history of 2+ weeks of delusions or hallucinations in the absence of prominent mood symptoms
Mood episodes are prominent and recur throughout illness
Not due to substances or another medical condition
DDx - psychotic disorders
- Brief psychotic disorder (1 day to <1 month, sudden onset, full return to function)
- Schizophreniform disorder (1 month to <6 months, schizophrenia symptoms, no functional decline required)
- Schizophrenia (6+ months with 1+ months active symptoms, requires functional decline)
- Schizoaffective disorder (mood episode with concurrent active-phase symptoms of schizophrenia + 2+ weeks of delusions or hallucinations in the absence of prominent mood symptoms)
- Delusional disorder (1+ delusions and 1+ month, no other psychotic symptoms, normal functioning except for direct impact of delusions)
Age of onset of the psychotic features of schizophrenia?
Between late teens and mid-30s
When the diagnosis of schizophreniform disorder is made without waiting for the patient to recover, it is specified as ___. If symptoms persist >6 months, the diagnosis is changed to ___.
Provisional; schizophrenia
Clinical features of PTSD?
Exposure to life-threatening trauma
Nightmares, flashbacks, intrusive memories
Avoidance of reminders, amnesia for event
Emotional detachment, negative mood, decreased interest in activities
Sleep disturbance, hypervigilance, irritability
Increased startle response
Duration 1+ months
Treatment of PTSD?
Trauma-focused CBT
Antidepressants
Prazosin for nightmares
What increases risk for PTSD in military veterans?
Repeated deployments
Longer duration
Higher severity of combat exposure
Clinical features of panic disorder?
Recurrent, spontaneous, unexpected panic attacks with 4+ of the following:
Chest pain, palpitations, SOB, choking Trembling, sweating, nausea, chills Dizziness, paresthesias Derealization, depersonalization Fear of losing control or of dying
1+ months of worry about additional attacks or avoidance behavior
Dx requires that at least some of the episodes are untriggered or unexpected
Treatment of panic disorder?
First-line/maintenance: SSRI/SNRI and/or CBT
Acute distress - benzodiazepines
When is anxiety disorder due to another medical condition diagnosed?
When the panic attacks are a direct physiological consequence of another medical condition (eg, hyperthyroidism, pheochromocytoma, arrhythmias, asthma)
Clinical features of GAD?
6+ months of persistent worry and anxiety about multiple issues
Difficult to control
3+ of the following symptoms: restlessness or feeling on edge, fatigue, difficulty concentrating, irritability, muscle tension, sleep disturbance
Significant distress or impairment
Not due to substances, another mental disorder, or a medical condition
Does not feature unexpected panic attacks
Following stabilization of acute symptoms, patients with bipolar disorder require maintenance treatment to delay or prevent recurrence of new mood episodes. Common first-line mood stabilizers?
Lithium
Valproate
Other options - quetiapine and lamotrigine
Why is lithium contraindicated in patients with renal dysfunction?
Lithium is excreted unchanged by the kidneys and may build up to toxic levels when used in patients with renal dysfunction
Long-term use has also been associated with nephrogenic DI and chronic tubulointerstitital nephropathy
True or false - topiramate has not demonstrated efficacy in acute or maintenance treatment of bipolar disorder.
True
What three things should be evaluated in a suicide risk assessment?
Ideation
Intent
Plan
What information should be included when evaluating suicidal ideation?
Passive (wish to die, not wake up) vs. active (thoughts of killing self)
Frequency, duration, intensity, controllability
What information should be included when evaluating suicidal intent?
Strength of intent to attempt suicide
Ability to control impulsivity
Determine how close patient has come to acting on a plan (rehearsal, aborted attempts)
What information should be included when evaluating suicide plan?
Specific details (method, time, place, access to means, preparations)
Lethality of method
Likelihood of rescue
What should be done for all patients presenting with depression?
Careful screening for suicide risk
Signs and symptoms of neuroleptic malignant syndrome?
Fever >40 C (104 F) common Confusion/mental status changes/delirium Muscle rigidity (generalized, lead pipe) Autonomic instability (abnormal vital signs - HTN, tachycardia, sweating)
CK and WBC may be elevated
Treatment of neuroleptic malignant syndrome?
Stop antipsychotics or restart dopamine agents Supportive care (hydration, cooling); ICU Dantrolene (direct-acting muscle relaxant) or bromocriptine/amantadine (reverse dopamine blockade) if refractory
What medications can cause NMS?
More commonly associated with high-potency first-generation antipsycsyndromeotics (eg, haloperidol), but can occur with every class, including second-generation
NMS should be differentiated from ___.
Serotonin syndrome
Signs and symptoms of serotonin syndrome?
Hyperthermia (usually not as high as NMS)
Autonomic instability
Mental status changes
Prominent GI symptoms
Neuromuscular irritability (hyperreflexia, myoclonus, tremor, NOT lead-pipe rigidity)
Cause of serotonin syndrome?
Typically due to a combination of serotonergic medications or the interaction of these medications and MAOIs (eg, phenelzine)
Compare NMS and SS.
NMS has a higher fever
SS has prominent GI symptoms and neuromuscular irritability (hyperreflexia and myclonus), NO lead-pipe rigidity
Both have autonomic instability and mental status changes
Characteristics of catatonia?
Syndrome of marked psychomotor disturbance with decreased motor activity, lack of responsiveness during interview, and posturing
Not associated with high fevers
What causes malignant hyperthermia?
Volatile anesthetics or succinylcholine
Dx - MDD?
2+ weeks
5+ of 9 symptoms - depressed mood and SIGECAPS
Significant functional impairment
No lifetime history of mania
Dx - adjustment disorder with depressed mood?
Onset within 3 months of identifiable stressor
Resolve 6 months after the stressor ends
Marked distress and/or functional impairment
Does not meet criteria for another DSM-5 disorder