Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Cancer > Psychiatric effects of cancer > Flashcards

Psychiatric effects of cancer Flashcards

1
Q

Which mental health condition is associated with smoking and lung cancer?

A

Schizophrenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Who are susceptible to steroid psychosis?

A

Bipolar patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bloods for depression and anxiety?

A 
FBC
LFT
TFT
U+E
Creatinine
Calcium
Vitamin B12
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Contraindication of epiltopgenic antidepressant medications?

A

Brain tumour

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Avoid SSRIs if…

A

If there is a current physical symptom burden e.g. nausea, diarrhoea, insomnia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Contraindication of antidepressant venlafaxine?

A

Hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Fluoxetine should be avoided as an anti-depressant therapy for cancer for what reason?

A

Drug-drug interactions

Citalopram and sertraline are better options

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Risks of anti-depressants in cancer care?

A

SIADH/hyponatraemia
GI bleeding with SSRIs (esp. with NSAIDs)
Serotonin syndrome (esp. with tramadol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which cancer has an 80% depression rate with psychotic features?

A

Pancreatic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Inflammatory explanation for depression in pancreatic cancer?

A

High IL-6 causes resistance to glucocorticoid receptor
This causes hypercortisolaemia
Induction of IDO leads to serotonin depletion and high levels of Kynurenine and its metabolites
Depressive symptoms proportional to IL-6 level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Frontal lobe tumour:

Organic psychiatry

A 
Apathy
Coarsened social skills
Expressive dysphasia
Disinhibition
Perseveration
Change in personality
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Temporal lobe tumour:

Organic psychiatry

A

Memory loss
Deja vu
Auditory hallucinations
Complex partial seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Pituitary tumour:

Organic psychiatry

A

Various endocrine effects on mental health

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Brain metastases are particularly likely with which cancers?

A

Small-cell lung
Advanced melanoma
Breast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Endocrine paraneoplastic syndrome in small-cell lung cancer?

A

Ectopic ADH secretion
Hyponatraemia
Lassitude, nausea, low mood
Delirium and fits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Endocrine paraneoplastic syndrome in non-small-cell lung cancer?

A 
Ectopic PTHrP secretion
Hypercalcaemia
Low mood
Thirst
Delirium
Constipation
17
Q

Give an example of a Neuropsychiatric paraneoplastic syndrome:

A

Limbic encephalitis

18
Q

What can cause limbic encephalitis?

A

Anti-Hu antibody in small-cell lung cancer

Anti-NMDAR antibody in teratoma

19
Q

Psych symptom of paraneoplastic anti-Hu secretion in small-cell lung cancer?

A

Dementia as the anti-Hu binds to neurones exclusively

20
Q

Psych symptoms of paraneoplastic anti-NMDAR secretion in teratoma?

A

Psychosis and schizophrenia due to glutaminergic hypofunction - treat by immunotherapy/removing teratoma in the ovary

21
Q

Non-psych symptoms of paraneoplastic anti-NMDAR secretion in teratoma?

A 
Opsoclonus
Nystagmus
Abnormal muscle tone/posture
Fits
Central hypoventilation
22
Q

‘Chemobrain’ side effects of antifolates:

A

Low mood and subtle cognitive impairment

Reason: demyelination, impaired hippocampal neurogenesis, reduced monoamine NT synth and build up of homocysteine

23
Q

Treatment for steroid psychosis?

A

Steroid reduction and olanzapine

24
Q

95% rate of what in whole brain radiotherapy?

A

Growth hormone deficiency (4 years later)

And 3-10 point IQ loss

25
Q

40% rate of what after head and neck radiotherapy?

A

Hypothyroidism (1 year later)

26
Q

Psych effect of PI3K/AKT inhibitors?

A

Sever depression - 30%

27
Q

Psych effect of proteosome inhibitors (myeloma treatment)?

A

Depression

28
Q

Psych effect of bevacuzumab (inhibits VEGF used in renal, colorectal and cervical cancers)?

A

Disrupts the BBB causing posterior reversible encephalopathy syndrome (PRES: pulsating headaches and confusion)

29
Q

Why is Rituximab given in PML?

A

Reactivation of childhood JC virus in severely immunocompromised state

30
Q

Psych effect of Rituximab in PML?

A

Clumsiness, visual field defects, cognitive impairment (30%), aphasia, personality changes and hemiparesis
Reason: Asymmetrical demyelination in white matter of parietal and occipital lobes
Treatment: steroids and plasmapheresis

31
Q

What is blinatumomab

A

Bi-specific antibody that acts as a T-cell engager
It targets CD19 on tumour cell and CD3 on T-cells to bring them together
Used in refractory B-cell ALL

32
Q

Psych effect of blinatumomab?

A

Confusion, dysphasia, somnolence, tremor, seizures, coma
Reason: T-cells cross BBB, bind to B-cells and incite cytokine storm
Prevention/management: infusion of high dose steroids

Cancer (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions