Psychedelic Medicine

Question 1

What are the features of psilocybin?

Answer 1

Effects of Psilocybin Total Time for Oral Synthesized:
- approximately 4-7 hours
(effects may vary with each individual; physical and mental effects do not necessarily
correlate with each other)

Duration:
- Onset - 15-40 minutes 
- Coming Up: 15-30 min
- Gliding Down: 1-3 hours (Effects
generally last for 6 hours, stay in Session Room for 8 hours)

Next day fatigue, or “hangover”:

• After Effects: 0-6 hours
• Plateau: 1-4 hrs

Chemical structure of psilocybin and psilocin similar to the neurotransmitter
serotonin:
- Involved in appetite, sleep, memory, learning, temperature, mood, behaviour,
muscle contraction, depression, CV function, endocrine and aging regulation, bone metabolism, wound healing, possibly migraine headache

Psilocin is the active agent after psilocybin has been ingested (phosphorus
removed)
- Primary effect of psilocin is on the receptors for serotonin

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Question 25

What are some key phenomenological descriptions of the psychedelic experience?

Answer 25

Good source:
- https://psychonautwiki.org/wiki/Subjective_effects_index

Divided into:

• Visual effects
• Cognitive effects
• Somatic effects

With further subdivisions

Visual:

• Enhancements (e.g. pattern recognition enhancement, magnification)
• Distortions (e.g. drifting, tracers, 3D textures)
• Geometry
• Hallucinations (e.g. internal, unspeakable horrors)

Cognitive:

• Enhancements (e.g. emotional, thought acceleration)
• Suppressions (e.g. memory suppression, language suppression)
• Novel states (e.g. time distortion, paranoia)
• Spiritual states (e.g. existential self-realisation)

Somatic:

• Enhancements (e.g. tactile, stimulation, auditory distortion)
• Suppressions (e.g. perception of decreased weight)
• Novel states (e.g. changes in bodily form, pupil dilatation)