Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psych: SD & Pharm > Psych Pharm > Flashcards

Psych Pharm Flashcards

You may prefer our related Brainscape-certified flashcards:
Psychology 101 flashcards GRE® Psychology flashcards
1
Q

medication category for:

first generation- haloperidol

second generation- risperidone

A

antipsychotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

medication category for:

MAOIs

tricyclics, tetracyclics

SRIs or SRAs

SSRIs, SNRIs

atypical’s or NDRI’s

5HT1a agonist/5HT3 antagonist

SSRI/5HT1a partial agonist

A

antidepressants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

medication category for:

lithium

anti-seizure drug- valproate

anxiolytics-antihistamine, anti-hypertensive, benzodiazepine

A

mood stabilizers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

medication category for:

zolpidem

ramelteon

temazepam

suvorexant

ADHD meds

A

hypnotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

can neural circuits “learn” over time?

A

yes

over-stimulated circuits become dysregulated

  • circuit activity breaks down resulting in dysfunction
  • circuit dysfunciton is seen as symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

stimulate receptors

A

agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

stimulate with ceiling & occupy receptor (which precludes other NT’s from attaching)

A

partial agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

block agonist from receptor

A

antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

blocks agonists at receptor & reduce activity below baseline constitute activity

A

inverse agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

psychiatric symptoms related to _______ _______

A

related to neural circuits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

circuit contains ________ and ________

A

neurotransmitters and receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

_______ activity drives symptoms

A

receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

modulate receptor activity with ______

A

drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

excess stimulation of the portions of the CNS that control motor function that are outside of the pyramidal tract

group of syndromes w/ signs of abnormal motor movement result from D2 antagonism (bradykinesia, incoordination, spasms)

A

extrapyramidal syndrome (EPS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

“late appearing dyskinesias”

a form of EPS

primarily orofacial dyskinesia

D2 receptor blockade

may be permanent

A

tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

excess level of 5HT producing akithesia, muscle twitching, hyper-reflexia, penile erection, seizures, coma

A

serotonin syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

excess antagonism of D2 receptor producing muscle rigidity, fever, unstable BP, myoglobinemia

may be fatal

an extreme manifestation

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

genetically determined hypersensitivity to anesthetic agents resulting in severe hyperthermia, accelerated muscle metabolism, metabolic acidosis

A

malignant hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

syndrome including:

at a minimum, hallucinations, delusions

frequently also disorganized speech and behavior, gross distortions of reality testing

A

psychosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

drug class for haloperidol

A

first generation antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

indications for haloperidol

A

psychotic symptoms

(defining & associative symptoms)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

MoA for haloperidol

A

D2 antagonist

inhibits alpha1, but not M1, H1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

drug class for risperidone

A

SGA

atypical antipsychotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

indications for risperidone

A

psychosis (positive & negative symptoms)

mania

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

MoA for risperidone

A

5HT and DA antagonist

mild alpha1, alpha2, H1 antagonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

drug class for quetiapine

A

SGA

atypical antipsychotic

D2 & 5HT antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

indications for quetiapine

A

bipolar disorder

schizophrenia

adjunct in MDD

off-label: GAD, OCD, PTSD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

MoA for quetiapine

A

D2 and 5HT2 antagonism

high affinity for M1 muscarinic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

drug class for lurasidone

A

SGA

atypical antipsychotic

D2, 5HT2, 5HT7 antagonist

5HT1a partial agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

indications for lurasidone

A

schizophrenia

bipolar 1 disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

MoA for lurasidone

A

D2, 5HT2, 5HT7 antagonist

5HT1 partial agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

drug class for ziprasidone

A

SGA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

indications for ziprasidone

A

bipolar disorder

schizophrenia

acute agitation in schizophrenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

MoA for ziprasidone

A

D2, 5HT2a, 5HT1d antagonist

5HT1a agonist

moderate 5HT and NE reuptake inhibition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

what do we want to rule out before treating what looks like depression?

A

mania

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

what is the black box warning for all young adults for all antidepressants?

A

suicide risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

treatment goals:

what is the success rate w/ antidepressants?

A

60-80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

after starting antidepressants, how long does it take to see improvements in emotions?

A

2-4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

how long does it take to see the full impact of antidepressants?

A

6-8 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

drug class for phenelzine

A

monoamine oxidase inhibitor (MAOI)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

indications for phenelzine

A

depression refractory to other Rx, ECT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

MoA for phenelzine

A

inhibition of MAO producing increased NE, DA, 5HT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

drug class for nortriptyline

A

tricyclic antidepressant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

indications for nortriptyline

A

depressive disorders

off-label: chronic pain, anxiety, enuresis, ADHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

MoA for nortriptyline

A

inhibit SERT, NET

block 5HT2A receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

drug class for mirtazapine

A

tetracyclic

alpha2 antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

indications for mirtazapine

A

depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

MoA for mirtazapine

A

antagonism of alpha2 receptors dishibits 5HT, NE release;

blocks NE negative feedback inhibits of NE, 5HT release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

drug class for trazadone

A

SARIs

5HT2A, 5HT2C antagonist & reuptake inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

indications for trazadone

A

MDD

insomnia (lower doses)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

MoA for trazadone

A

antagonist of 5HT2A, 5HTC and inhibits reuptake serotonin via SERT, reduces number of 5HT receptors & increasing 5HT flow in neuron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

drug class for fluoxetine

A

selective serotonin reuptake inhibitor (SSRI)

53
Q

indications for fluoxetine

A

MDD

dysphoric disorder

anxiety

eating disorders

OCD

54
Q

MoA for fluoxetine

A

inhibit reuptake serotonin via SERT reducint number 5HT receptors & increasing 5HT flow in neuron;

mild NRI, DRI, 5HT2C inhibition, CYP2D6 & 3A4 inhibition

55
Q

drug class for sertraline

A

SSRI antidepressant

56
Q

indications for sertraline

A

MDD
PMDD

PD

PTSD

social anxiety disorder

OCD

57
Q

MoA for sertraline

A

selectively inhibits SERT & increases 5HT level in synapse

58
Q

drug class for citalopram

A

SSRI antidepressant

59
Q

indications for citalopram

A

depression

60
Q

MoA for citalopram

A

selectively inhibits SERT & mild antihistamine (H1) activity

61
Q

drug class for venlafaxine

A

serotonin & NE reuptake inhibitors (SNERIs)

62
Q

indications for venlafaxine

A

MDD
GAD

SAD

panic disorder

off-label: pain, OCD, hot flashes

63
Q

MoA for venlafaxine

A

inhibits SERT at lower doses, NET at high doses

64
Q

drug class for duloxetine

A

SNERI antidepressant

65
Q

indications for duloxetine

A

MDD

DPNP

fibromyalgia

GAD

chronic MSK pain

66
Q

MoA for duloxetine

A

elevates levels of 5HT, NE, and DA

elevates DA levels in PFC

67
Q

drug class for buproprion

A

NE, DA reuptake transporter inhibitors (NDRIs)

68
Q

indications for buproprion

A

depression

smoking cessation

69
Q

MoA for buproprion

A

NE, DA reuptake inhibition

70
Q

drug class for vortioxetine

A

SSRI

71
Q

indications for vortioxetine

A

MDD

72
Q

MoA for vortioxetine

A

inhibits SERT, partial agonist at 5HT1a and 5HT3 antagonist

73
Q

drug class for vilazodone

A

SPARI (serotonin partial agonist reuptake inhibitor)

74
Q

indications for vilazodone

A

MDD

75
Q

MoA for vilazodone

A

inhibits SERT with elevatio of 5HT levels & has 5HT1a partial agonist activity

76
Q

drug class for lithium

A

mood stabilizer

77
Q

indications for lithium

A

bipolar disorder

mania

78
Q

possible SE/ADR of lithium

A

diabetes insipidus

79
Q

drug class for valproate

A

anti-seizure med

mood stabilizer

80
Q

indications for valproate

A

seizure disorder

mania

aggression

81
Q

MoA for valproate

A

increase GABA concentration

82
Q

drug class for hydroxyzine

A

antihistamine (H1)

anxiolytic

83
Q

indications for hydroxyzine

A

anxiety, pruritis, sedation

84
Q

MoA for hydroxyzine

A

inhibits H1 receptors

85
Q

drug class for propanolol

A

beta blocker

anxiolytic

86
Q

indications for propanolol

A

HTN

anxiety

tremor

hyperthyroidism

87
Q

MoA for propanolol

A

nonselective beta blocker

88
Q

drug class for diazepam

A

benzodiazepine anxiolytic

89
Q

indications for diazepam

A

bridge therapy in anxiety disorders

sedative, status epilepticus, alcohol withdrawal

90
Q

MoA for diazepam

A

binds to & stabilizes BZD receptor on post-synaptic GABA neuron in limbic system & reticular formation enhancing GABA impact

91
Q

drug class for oxazepam

A

benzodiazepine anxiolytic

92
Q

indications for oxazepam

A

bridge therapy in anxiety disorders

sedative, alcohol withdrawal

93
Q

MoA for oxazepam

A

binds to & stabilizes BZD receptor on post-synaptic GABA neuron in limbic system & reticular formation enhancing GABA

94
Q

drug class for buspirone

A

miscellaneous anxiolytic

95
Q

indications for buspirone

A

anxiety

96
Q

MoA for buspirone

A

5HT1A partial agonist modulates 5HT levels

97
Q

drug class for zolpidem

A

non-benzodiaepine hypnotic

98
Q

indications for zolpidem

A

short-term treatment insomnia

99
Q

MoA for zolpidem

A

selective agonist for alpha1 subunit of BZD receptor of GABA receptor complex -> increase GABA impact

100
Q

drug class for esopiclone

A

hypnotic, nonbenzodiazepine

101
Q

indications for esopiclone

A

insomnia

102
Q

drug class for zaleplon

A

hypnotic

nonbenzodiazepine

103
Q

indications for zaleplon

A

short-term treatment insomnia

104
Q

drug class for ramelteon

A

hypnotic

miscellaneous

105
Q

indications for ramelteon

A

insomnia

106
Q

drug class for temazepam

A

hypnotic

benzodiazepine

107
Q

indications for temazepam

A

short-term treatment of insomnia

108
Q

drug class for suvorexant

A

hypnotic

orexin receptor antagonist

109
Q

indications for suvorexant

A

insomnia

110
Q

MoA for suvorexant

A

blockes wake-promoting orexin-A and orexin-B to receptors OX1R and OXR2 which suppresses wake drive

111
Q

what are the 2 ADHD meds?

A

methylphenidate

atomexetine

112
Q

drug class for methylphenidate

A

CNS stimulant

113
Q

indications for methylphenidate

A

symptomatic treatment of ADHD, narcolepsy

off-label: depression in terminally ill

114
Q

drug class for atomexetine

A

SNRI

115
Q

indications for atomoxetine

A

ADHD

116
Q

drug class for acamprosate

A

GABA agonist/glutamate antagonist

117
Q

indications for acamprosate

A

maintenance of alcohol abstinence

118
Q

drug class for disulfram

A

aldehyde dehydrogenase inhibitor

119
Q

indications for disulfram

A

maintenance of alcohol abuse

120
Q

drug class for naltrexone

A

opioid antagonist

121
Q

indications for naltrexone

A

maintenance of alcohol or opioid absitnence

off-label: cholestatic pruritis

122
Q

drug class for methadone

A

opioid analgesic

123
Q

indications for methadone

A

low doses- analgesia

treatment of opioid addiction

124
Q

drug class for buprenorphine

A

opioid partial agonist

125
Q

indications for buprenorphine

A

analgesia

opioid withdrawal

dependence

126
Q

drug class for naloxone

A

opioid antagonist

127
Q

indications for naloxone

A

opioid overdose

128
Q

drug class for buprenorphine & naloxone

A

opioid partial agonist & opioid antagonist

129
Q

indications for buprenorphine & naloxone

A

maintenance herapy for opioid dependence

*not for induction of abstinence

Psych: SD & Pharm (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions