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Year 3 > Psych drugs > Flashcards

Psych drugs Flashcards

1
Q

type of drug -

sertraline

A

SSRI

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2
Q

type of drug -

FLUOXETINE

A

SSRI

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3
Q

type of drug -

PAROXETINE

A

SSRI

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4
Q

type of drug -

CITALOPRAM

A

SSRI

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5
Q

type of drug -

ESCITALOPRAM

A

SSRI

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6
Q

type of drug -

AMITRIPTYLINE

A

TCA

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7
Q

type of drug -

LOFEPRAMINE

A

TCA

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8
Q

type of drug -

CLOMIPRAMINE

A

TCA

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9
Q

type of drug -

DOSULEPIN

A

TCA

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10
Q

type of drug -

VENLAFAXINE

A

SNRI

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11
Q

type of drug -

DULOXETINE

A

SNRI

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12
Q

type of drug -

MIRTAZAPINE

A

NASSA
noradrenaline serotonin specific antidepressant

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13
Q

type of drug -

MOCLEBEMIDE

A

MAOI
monoamine oxidase inhibitors

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14
Q

type of drug -

PHENELZINE

A

MAOI

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15
Q

type of drug -

TRAZADONE

A

SARI

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16
Q

SSRI MOA

A

block serotonin reuptake from synaptic cleft
overall reduction in inhibitory controls of serotonin release

17
Q

SSRI main S/E

A

GI upset - abdominal pain, constipation, nausea

18
Q

TCA MOA

A
  • block reuptake of noradrenaline
  • block reuptake of serotonin
    ^ via blocking their transporter
19
Q

which molecules are antagonised by TCAs?

A
  • histamine
  • dopamine
  • acetylcholine
20
Q

main TCA S/Es

A
  • sedative
  • weight gain
  • anticholinergic syndrome - dry mouth + constipation
21
Q

MOA of SNRI

A

selectively block noradrenaline and serotonin (TCA are not selective)

22
Q

main SNRI S/Es

A

GI upset
hypertension
palpitations

23
Q

MOA for mirtazapine

A

presynaptic antagonism of:
- noradrenaline
- serotonin
- histamine

24
Q

which drug blocks alpha2-adrenergic receptors, causing increase in neurotransmitter release?

A

mirtazapine

25
Q

which drug can be used to counter S/E of SSRI?

A

mirtazapine

26
Q

MOA of MAOI

A
  • block monoamine oxidase
  • prevents breakdown of serotonin + noradrenaline
27
Q

reversible MAOI?

A

moclebemide

28
Q

Irreversible MAOI

A

phenelzine

29
Q

sodium valproate MOA

A

blocks voltage sensitive Na channels
increase in GABA level

30
Q

lamotrigine MOA

A

blocks voltage sensitive Na channels

31
Q

mood stabiliser causing SJS

A

lamotrigine

32
Q

MOA for typical anti-psychotics

A

block dopamine
D2 receptors

33
Q

extra-pyramidal side effects caused by?

A

typical anti-psychotics

34
Q

examples of extra-pyramidal S/Es

A

acute dystonia
akathisia
Parkinsonism
tardive dyskinesia

35
Q

muscle rigidity, feber, autonomic instability + cognitive changes - in responsive to antipsychotics (usually 1st gen)

A

neuroleptic malignant syndrome

36
Q

how can extra-pyramidal S/Es be managed

A

procyclidine

37
Q

rapid tranquillisation

A

1st - oral lorazepam

2nd - IM ^

38
Q

MOA of benzodiazepines

A

activate GABAa receptors
causes inhibition of neurotransmission
hence sedative relaxing affect

39
Q
A

Year 3 (2 decks)

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