Psych Flashcards
ou are an FY2 working in a GP practice. See an 30 year old man with a year history of low mood, inability to concentrate in his job and lack of interest in socialising with others. He reports some recent episodes of self-harm and says he feels worthless and guilty most days. He is currently on 50mg OD PO sertraline.
What are the core symptoms of depression and some others?
Low mood Anergia Anhedonia Difficulty sleeping Not eating as well Loss of libido Loss of confidence Loss of concentration Suicidal ideation/self harm Feelings of guilt
How long do the symptoms have to be ongoing for to make a diagnosis of depression?
2 weeks minimum
Using the bio psychosocial model , what are the risk factors for depression?
Biological: genetics
Psychological: low self esteem, past history of child abuse or loss of parent, anxious personality
Social: recent tragic life incidents eg. loss of someone ,unemployment, homelessness. Lack of friends.
Chronic pain eg. fibromyalgia
What screening tool can be used in GP for depression?
PHQ-9
What are the treatment options used in depression?
- CBT, group therapy, IAPT in Sheff
May also need medication if more severe: - SSRI eg. sertraline, citalopram
- Mirtazipine (NAssA) or SNRI- venlafaxine
3rd; MOA inhibitors e.g rasigiline or TCA- clomipramine , amitryptilline
What are some side effects of SSRIs?
Initially- suicidal ideation increases Sexual dysfunction Weight loss Diarrhoea Insomnia
What are some side effects of TCAs?
Can’t spit, can’t shit, can’t see , can’t pee
Dry mouth, constipation, blurred vision, urinary retention
cardiac problems
What do you need to warn patients about who are on MAO inhibitors?
eating any tyramine rich foods eg. cheese, red wine, beer
What can be tried to treat severe depression not responding to any treatment?
ECT
What are side effects of ECT?
Memory loss- retrograde, aching muscles, headaches, confusion
What are some risk factors for suicide?
Risk factors:
- Unemployed
- No family or friends nearby
- Multiple previous attempts of self harm/sucicide
- Planning the next attempt i.e leaving a note or making sure no one finds them
- Male
- Alcohol or drug misuse
- History of mental illness
- History of chronic disease
- Sorting out any final acts eg. selling belongings/ paying bills
Miss L is a 23 year old, single and shares a flat with her mother. She received SSRI treatment for depression 2 years ago following a termination of pregnancy. Her mother has brought her to see the GP as she is concerned that Miss L is “not herself”. Miss L appears excessively cheerful and talks loudly and quickly. She is wearing a lot of makeup in vivid colours. She tells you she is absolutely fine although sometimes she has trouble sleeping. She believes she is going to achieve stardom and become a world famous popstar next month. It is difficult to get a history from her as she changes the subject frequently, appears offended by some questions and laughs inappropriately at others. What is the likely diagnosis -specifically?
Bipolar disorder
Type 1 - mania and depression
What is the difference between hypomania and mania?
Mania will have psychotic symptoms eg. grandiose delusions, persecutory delusions
How will you manage an acute manic episode?
Antipsychotics eg. olanzapine
What is good to give to help treat the acute depressive episode?
Lamotrigine
Fluoxetine and olanzipine
You have diagnosed Miss L with bipolar disorder and treated her acute manic episode with olanzapine. You now need to manage her chronically. What are the options for treatment? Which one can you give 25 year old Miss L who doesn’t take any medication ?
Lithium
Sodium valproate
Antipsychotics eg. olanzapine
Lithium! - don’t need to be on contraception
Need to be on contraception to give sodium valproate
What are the side effects of lithium?
LITHIUM
Leucycottosis, inspidus, tremor, hydration- polyuria, polydipsia , GI disturbances, underactive thyroid- hypothyroid, metallic taste in mouth
Patient starts on lithium. Is having levels regularly monitored (weekly to begin with), 3 monthly once stable. Then presents to A+E with coarse tremor, blurred vision, jerking of her arms, diarrhoea and vomiting. What has happened and how do you manage?
Lithium toxicity
Bloods: FBC, U&E, LFTs, lithium level, TFTs
Stop lithium and supportive tx- rehydrate
Ms M is 32 years old with a known history of alcohol has been attending Alcoholics Anonymous. Members of these groups have asked her to seek help as she believes that a number of them are talking about her and calling her “paedo” (though they have reassured her that this is not the case). During the interview she seems nervous and distracted. Her speech is sometimes garbled, and she flits from one subject to a seemingly unrelated other one frequently. She says there is a conspiracy to frame her as a “paedo”. She tells you that staying clean and sober is extremely important to her, but that she feels she can no longer trust the other group members and is now reluctant to attend 12‐step meetings. What symptoms of schizophrenia is she showing?
Delusions
Thought disorder- Knight’s move thinking (flits from one subject)
Pressure of speech
What are the first rank symptoms of schizophrenia? What are some others?
First rank: 3rd person auditory hallucinations Delusional perceptions Passivity phenomenon Thought disorder- thought broadcast, thought echo, thought insertion, thought withdrawal
Others: delusions, 2nd person auditory hallucinations, visual hallucinations, thought disorder eg. Knight’s move thinking- jumping from topic to topic, negative symptoms- apathy, blunted responses, catatonia
What is schizoaffective disorder and how is it treated?
Experience symptoms of mood disorder and schizophrenia at the same time and of the same intensity Tx: antipsychotic and mood stabiliser.
What is schizotypal?
It is a personality disorder with some schizophrenia symptoms
What is schizophreniform?
Fail to meet the criteria for schizophrenia but have some symptoms with deterioration in function.
Ms M is 32 years old with a known history of alcohol has been attending Alcoholics Anonymous. Members of these groups have asked her to seek help as she believes that a number of them are talking about her and calling her “paedo” (though they have reassured her that this is not the case). During the interview she seems nervous and distracted. Her speech is sometimes garbled, and she flits from one subject to a seemingly unrelated other one frequently. She says there is a conspiracy to frame her as a “paedo”. She tells you that staying clean and sober is extremely important to her, but that she feels she can no longer trust the other group members and is now reluctant to attend 12‐step meetings. She is diagnosed with schizophrenia.
What is her bio psychosocial plan for management?
Biological: atypical antipsychotic eg. olanzapine, risperidone
Psychological: CBT, alcoholic support groups - maybe a different one or involve the substance abuse team.
Social: address any job or housing issues, family issues?
What are some first generation (typical) antipsychotics? How do they work?
Haloperidol, Chlorpromazine, prochlorpromazine, sulpiride. They block D2 (dopamine) receptors
What are some side effects of 1st generation antipyschotics?
ESPEs
Tardive dyskinesia - lip smacking, chewing, grimacing
Akasthisia - pacing, inner restlessness
Parkinsonism
Acute dystonic reaction - muscular spasms, acute torticollis, ocular gyrate crisis
How do you treat acute dystonic reaction?
IV fluids, procyclidine (anticholinergics)
How do you treat tardive dyskinesia?
Very difficult - tetrabenazine
How do you treat akathisia?
Propranolol and switch to second gen antipschyotic
How do 2nd gen antipsychotics work and what are there side effects?
Block dopamine D2 receptors and serotonin receptors
Side effects:
weight gain, diabetes, hyperlipidaemia, hyperprolactinaemia- galactorrhea, amenorrhea, infertility, erectile dysfunction
What needs to be monitored when a patient is on antipsychotics?
ECG- long QT Bloods: FBC, U&E, LFTs, prolactin, glucose, lipids , HBA1c Side effects Weight and waist circumference BP
What are the 3 clusters of personality disorders and an example from each?
Cluster A: odd/eccentric ‘Mad’- schizotypal, paranoid PD
Cluster B: dramatic/emotional ‘Bad’ - emotionally unstable , antisocial, histrionic, PD
Cluster C: anxious/avoidant ‘Sad’ - dependent, obsessive compulsive PD