Obstetrics Flashcards
What is the average length of a normal pregnancy?
37-42w
What does gravidity and parity mean?
Gravidity: total number of pregnancies
Parity: total number of pregnancies >24w
What are the normal changes in pregnancy (cardiac)? (3)
Increase in cardiac output due to Increase in SV and HR BP first drops then rises Slight cardiomegaly Decrease in peripheral resistance Ejection systolic murmur Compression of IVC
What are the normal changes in pregnancy (blood)? (2)
Dilutional anaemia: increase in plasma volume, decrease in Hb
Decreased albumin
Increased fibrinogen and clotting factors
What are the normal changes in pregnancy (resp)? (3)
Increased tidal volume
Increased minute ventilation- but no increased RR
Some SOB
What are the normal changes in pregnancy (endo)? (3)
Increased thyroid size and parathyroid
Increased basal metabolic rate
Increased prolactin through
What are the normal changes in pregnancy (uterus)? (2)
Increased uterus size
Braxton Hick contractions
What are the normal changes in pregnancy (gastro)? (3)
Constipation and haemorrhoids- due to reduced gastric emptying
GI reflux
Nausea and vomiting
Increased renal blood flow and GFR
In normal pregnancy: what effects does the increased oestrogen production have on the breast and vagina? (3)
Increase in breast and nipple size
Vaginal hypertrophy
Increased discharge
At what dates should the booking visit occur and what is done in it?
Before 12w- ideally 10w
FBC, blood group, HIV, serology for syphillis (VDRL), Hep B, rubella
What supplement do pregnant women need to take and for how long for and what dose?
Folic acid from pre-conception to 12w gestation
Low risk: 0.5mg
High risk: 5mg (DM, obesity, PMH of spina bifida)
When is the main ultrasound scan and what does it look for?
11-13+6 looking for:
- Dating: using crown rump length - estimate gestational age
- Nuchal translucency - for chromosomal abnormalities + beta-HCG, PAPP-A (pregnancy associated plasma protein A) (combined test)
- Viability of the pregnancy
- Presence of multiple pregancies
What is involved in the combined and quadruple tests that can be offered to screen for chromosomal abnormalities e.g. Down’s, Patau’s, Edwards and at what times?
Combined test: between 11 + 13+6: NT + beta HCG + PAPP-A
Quadruple test if they have missed combined test at 18-20 weeks (2nd trimester): AFP + unconjugated estriol + inhibin A +beta HCG
If the combined test is positive/baby is high risk for or chromosomal abnormalities e.g. Down’s, Patau’s, Edwards, what further two tests can be offered and when?
Chorionic villus sampling at 11-14w: safer than amnio
Amniocentesis at 15- 20w: risk of miscarriage, infection, pre-term labour
What is the scan at 18-20 weeks looking at?
Anomaly scan: looking for foetal abnormalities like spina bifida or anencephaly.
Rhesus haemolytic disease has occurred in this women’s pregnancy. Is she rhesus + or - and is the foetus rhesus + or -?
Foetus: rhesus + (DD/Dd)
Mother: rhesus - (dd)
Mother creates anti-D antibodies to foetus which cross placenta and destroy foetal RBCs (haemolytic anaemia )
How can you prevent rhesus haemolytic disease from occurring?
Give anti-D to rhesus -ve mothers at 28w
What are some maternal complications of multiple pregnancy? (3)
Polyhydramnios Pre-eclampsia APH and PPH Instrumental delivery Anaemia- increased iron and folate requirements Gestational Diabetes Placental abruption
What are some foetal complications of multiple pregnancy? (3)
Foetal mortality
Growth restriction
Prematurity
Malformations
What is the risk in monochorionic twins?
They share placenta: risk of foeti-foetal transfusion: blood flow doesn’t flow evenly between them
What is the cause of polyhydramnios and what are some risk factors?
Due to increased foetal urination and decreased foetal swallowing
RF: multiple pregnancy, trisomy 18 & 21, diabetes, oesophageal atresia of foetus
How is polyhydramnios treated?
Serial ultrasounds
Maternal steroids
May consider indomethacin or drainage
What is the definition of small for gestational age and what are some risk factors (3)?
Symphysial fundal height <10th gentile for their gestational age. RF: maternal smoking, multiple pregnancy, maternal age >40, pre-eclampsia, previous SGA baby
What are some risks of SGA baby?
Prematurity, foetal distress and meconium aspiration, foetal mortality (hypoxia), cerebral palsy
What is the definition of intrauterine growth restriction and what are some risk factors? (3)?
IUGR: estimated foetal weight <10th centile - slow growth.
RF: maternal smoking, alcohol & drugs, pre-eclampsia, maternal conditions eg. renal failure, IBD, CF, asthma , multiple pregnancy
What investigations are done in a foetus with IUGR?
Serial abdo circumference- SFH Serial Ultrasound scans CTG - assessment of cardiac oxygenation Amniotic fluid index Regular umbilical artery doppler- if reversed/absent end diastolic flow = may need C-section and steroids
What is the definition of small for dates?
Foetus with birth weight <10th centile on customised growth charts
What is the definition of large for dates and how is it measured?
Weight >90th gentile on customised growth chats
Measure with SFH and serial US
What is the main risk factor for large for dates/foetal macrosmia and what is the main complication?
Gestational diabetes , polhydramnios
Risk of shoulder dystocia- may need C section if baby >4.5kg
Heather is a 30 year old woman. She is currently experiencing lower abdominal pain and vaginal bleeding. Her last period was 14 weeks ago, and she had a positive pregnancy test 12 weeks ago. What is the diagnosis?
Miscarriage: loss of pregnancy <24w
What are the features of a threatened miscarriage? Is cervical os open or closed?
Mild painless bleeding, cervical os closed. 75% settle themselves.
What are the features of a inveitable miscarriage? Is cervical os open or closed?
About to miscarry- either after threatened or by itself. Heavier bleeding with clots. Cervical os is OPEN.
What are the features of a incomplete miscarriage? Is cervical os open or closed?
Most POC passed, some left in uterus. Cervical os is open. May need dilation and curettage.
What are the features of a complete miscarriage? Is cervical os open or closed?
All POC passed, US: empty cavity. May be bleeding and labour like cramps. cervical os is closed
What are the features of a missed miscarriage? Is cervical os open or closed?
Foetus has died but remains in uterus. TVUS: foetal pole large and no foetal heart activity. May have had a past bleed. Cervical os is closed.
What are the features of a septic miscarriage?
Infected contents of uterus- painful uterus, peritonism signs (swelling abdo, pain).
Heather is a 30 year old woman. She is currently experiencing lower abdominal pain and vaginal bleeding. Her last period was 14 weeks ago, and she had a positive pregnancy test 10 weeks ago.
Heather’s cervix is open and she is having an inevitable miscarriage.
Obs: BP 90/58, HR 105, RR 20, Temp: 36.9
What is your initial management?
ABCDE
Profuse bleeding: IM ergometrine
What are the options for treatment of a miscarriage?
Expectant: wait 7-14 days for miscarriage to complete itself.
Medical management: if expectant doesn’t work/pt preference: vaginal misoprostol
Surgical: suction/theatre if heavy bleeding, infection, severe pain. Give anti-D
Katrina was diagnosed with endometriosis. She underwent laparoscopy with surgical ablation and now takes ibuprofen for pain.
A year later, she presents to A&E with abdominal pain and some vaginal bleeding. She has vomited a few times. She is sexually active and her last period was 8 weeks ago.
What is the diagnosis?
Ectopic pregnancy
What is the most common site for implantation in ectopic pregnancy?
Ampulla of Fallopian tube
What are some risk factors for ectopic pregnancy?
PID, previous ectopic, endometriosis, surgery to tubes eg. tubal ligation, IVF, smoking
What are the symptoms of ectopic pregnancy?
Abdo pain- unilateral (LIF), colicky then constant
Dark PV bleeding
N&V
Syncope
Shoulder tip pain - bleeding irritates phrenic nerve
What are some signs of ectopic pregnancy?
Cervical excitation
Pelvic tenderness
Hypotension , tachycardia
Katrina was diagnosed with endometriosis. She underwent laparoscopy with surgical ablation and now takes ibuprofen for pain.
A year later, she presents to A&E with abdominal pain and some vaginal bleeding. She has vomited a few times. She is sexually active and her last period was 8 weeks ago.
What investigations might you do?
Bloods- FBC, U&E, group and save, beta HCG (high)
Pregnancy test
TVUS - no intrauterine pregnancy
this is an ectopic
What are the options for treatment of ectopic pregnancy?
Expectant: mild symptoms, beta-HCG is low and falling. Do serial beta HCGs
Medical: methotrexate 1 dose. CI: live ectopic.
Surgical: symptoms, very high beta HCG. Laprascopic salpingectomy if other tube is healthy or salpingotomy if other tube is not healthy/retain fertility
What are some risk factors for hyperemesis gravidarum
RF: multiple pregnancy, molar pregnancy, previous hyperemesis gravidarum
A pregnant lady in her 14th week gestation presents complaining of severe nausea and vomiting. She says its been getting so bad she’s unable to eat or drink anything at all. She says she’s tried eating small amounts and tried having ginger but nothing has helped. She also describes feeling dizzy. On examination- she has dry mucous membranes, is hypotensive and has reduced skin turgor. How are you going to manage this?
Hospital admission for IV fluids - normal saline with potassium or hartmann’s
Anti-emetics- promethazine/cyclizine
Thiamine replacement IV in hospital
This is hyperemesis gravid arum
What are the two types of gestational trophoblastic disease?
Molar pregnancy
Choriocarcinoma
What happens in a molar pregnancy?
Abnormal fertilised egg implants in uterus. The cells proliferate without control and take over–> instead of foetus, get a mass of abnormal cells (trophoblast) which produce beta hCG as derived from chorion.
How do you investigate (what would you see) and treat molar pregnancy?
beta- HCG raised and US- snowstorm appearance of swollen villi and moles
Tissue is removed with gentle suction
How do you diagnose pre-eclampsia?
HTN: BP >140/90
Proteinuria: 0.3g/24h
What are some risk factors for pre-eclampsia?
Diabetes, previous pre-eclampsia, previous HTN, renal disease eg. CKD, FMH
What investigations do you want to do in a patient with pre-eclampsia?
Dipstick for proteinuria
FBC, U&E, LFTs, clotting
TVUS
How do you treat pre-eclampsia (mild, moderate, severe)?
Mild: regular blood tests- FBC, U&E, LFTs, foetal scans , regular BP
Moderate: treat if BP >150/100= labetalol
Severe: labetalol (2nd line=nifedipine), Mg sulphate as prophylaxis for pre-eclampsia
What can you give to patients with a high risk of pre-eclampsia eg. past history/FMH?
Aspirin from 12s
A lady comes in with known pre-eclampsia and has been monitored throughout with regular blood tests and blood pressure checks. Today she has come to A&E as she’s got a very bad headache, feels drowsy, her vision has blurred and she’s had 2 seizures where she has fallen to floor and her arms have gone stiff and shook. What’s happened and how are you going to treat?
Eclampsia
Magnesium sulfate IV
What does HELLP syndrome stand for and when does it occur?
Complication of pre-eclampsia
Haemolysis + elevated liver enzymes + low platelets
causes RUQ pain
How do you treat HELLP syndrome?
Deliver if >34 weeks
Tranfuse Hb, platelets , FFP
What are the cut offs for gestational hypertension diagnosis? and how to treat?
BP >140/90
lifestyle, if need meds: oral labetalol
What tests can be done to diagnose gestational diabetes?
Random fasting glucose >7
2 hour OGTT at 28w (if RF)= >8.5
What are some risk factors for gestational diabetes? What test will you do for those with risk factors?
FMH of GD Previous GD in prev pregancy Increased BMI Ethnicity -SA, carribean increasing age
OGTT at 28weeks
What are some foetal complications of gestational diabetes?
Macrosomia
Shoulder dystocia
Congenital abnormalities e.g.neural tube and cardiac
Post natal: hypoglycaemia (baby is accustomed to hyperglycaemia), jaundice
What are some maternal complications of gestational diabetes?
Pre-eclampsia (and risk of HELLP) Birth trauma and instrumental delivery Hypoglycaemia Retinopathy Post natal: increased risk of T2DM, hypoglycaemia
A pregnancy lady has an OGTT at 28 weeks due to having previous gestational diabetes in her last pregnancy. Her value comes back at 9 and her fasting plasma glucose is 7.5mmol/L. Foetal US has shown the baby to have a large head. What treatment are you going to offer?
Start insulin straight away as OGTT >8.5 and fasting plasma glucose >7 with foetal macrosmia.
What are the options for treatment of gestational diabetes?
First line: lifestyle- diet, exercise, weight loss
If >2 weeks and no change: insulin
Metformin only if CI to insulin
What are the TORCH infections?
Infections of foetus - toxoplasmosis, other- syphillis, varicella zoster, parvovirus B19, rubella, CMV and herpes
What complications to the foetus occur with CMV infection?
IGUR, hydrocephalus, motor and sensory impairment, deafness
How do you prevent herpes zoster infection travelling from mother to neonate?
Give baby varicella immune immunoglobulin (VIZG) at birth. C-section if within 6 weeks of onset.