Psych Flashcards
4 features of Neuroleptic Malignant Syndrome + common meds involved (3)
- EPSE - rigidity, dystonia, dysphagia
- Temperature dysregulation - >39
- Autonomic side effects - tachycardia, hypertension, sweating
- CNS effects - drowsiness, confusion
Meds - Metoclopramide, prochlorperazine, domperidone
Neuroleptic malignant syndrome Mx steps in ED (5)
- Stop any offending medications
- Commence bromocriptine +- in consultation with clinical toxicologist
- Insert 2x large bore cannulas
- Cooloing with ice packs
- Sedation with low dose BZD
Exam: Outpatient management of acute psychosis- acutely psychotic, psych review 2-3days, not at high risk?
-> If possible delay anti-psychotic to allow for assessment and diagnosis
-> If interim Rx needed for acute agitation = oral diazepam 5-10mg Q4H (Max40mg daily)
KFP: DDx for psychotic symptoms (4+4+4)
- Psychotic disorders
- Schizophreniform disorder (<6mo)
- Schizophrenia (>6mo)
- Substance-induced psychotic disorder (long than intoxication, but <4wks)
- Schizoaffective disorder (Schizophrenia Sx with prominent mood Sx) - Other psychiatric disorders
- Acute mania
- Post-partum-psychosis
- Psychotic depression
- Personality disorder - Medical/other
- Dementia (with Lewy body)
- intracerebral mass
- Delirium
- Tertiary syphillis
3 primary psychotic disorders that differ with timing?
- Brief psychotic disorder (resolve <1mo)
- Schizophreniform disorder (1mo-<6mo)
- Schizophrenia (>6mo)
KFP: Hx to assess risk of suicide in patient with SI, but no intent or plan? (6)
- Past hx of SI or DSH
- Access to firearms (or similar lethal method)
- Lack of social support
- History of concurrent substance use
- Compensatory behaviours (giving away belongings)
- Exposure to suicide of family member or loved one
KFP: Pt with depressive symptoms, also has better periods. Hx to assess possibility of mania/Type 2 Bipolar (5)
- Decreased need for sleep
- Delusions of grandiosity
- Increased sexual disinhibition (grouped with all risk taking behaviour)
- How long did this period last for (Hypomania >4days)
- Hallucinations?
Possible AEs with lithium use (5)
- Renal (impacts concentrating ability -> thirst + polyuria)
- Thyroid (reduces availability of thyroxine)
- Parathyroid (causes hyperCa from 2ndry hyperPTH)
- Weight gain (~5%)
- Teratogenic (consult obs/gyn)
KFP. 28F presents in clear mania. Mx actions (3)
- Urgent referral to ED for psychiatric review
- Schedule under MHA if does not consent to voluntary treatment
- Discuss with psychiatrist on call
Pharmacological management of acute mania (2)
Anti-psychotic PLUS mood stabliser
eg. olanzapine + lithium
Anti-psychotic for acute mania symptoms, and stop once settles
Concurrent mood stabliser for long term
Safest anti-depressant for pregnancy
Sertraline
48M, history of HTN, hypercholesterolaemia and schizophrenia. On perindopril, atrovatastatin and clozapine. Presents with fever 38.2, unclear focus. Co-incidentally had FBE yesterday which was normal. What needs to be considered and investigated?
Clozapine AE-
- neutropaenia +- myocarditis
Needs urgent ECG, trop + CRP if present with fever >38
KFP: Examples of drugs associated with serotonin syndrome (1+4)
- SSRI + SNRIs
PLUS - some TCAs (clomipramine)
- some opioids (tramadol, tapentadol, methadone)
- Stimulants (cocaine, meth, ecstasy)
- mood stabilizer (lithium)
3 features of serotonin syndrome
anyone CAN get serotonin syndrom
1. Cognitive - agitiation, confusion
2. Autonomic - hypertension, tachycardia, fever
3. Neurological - hyperreflexia, tremor, seizure
3 pharma options for alcohol dependency with main contraindications or consideration?
- Naltrexone (liver disease, opioid use)
- Acamprosate (renal disease)
- Disulfiram (ongoing drinking)