Psych Flashcards
what is Russels sign
calluses on the knuckles or back of the hand due to repeated self-induced vomiting - due to bulimia
what is the name of the fine hairs associated with an6aemia
lanugo hair
what form of memory loss is found in depression
global (short, long-term, working memory loss)
Factors suggesting diagnosis of depression over dementia
short history, rapid onset
biological sx e.g. weight loss, sleep disturbance
patient worried about poor memory
reluctant to take tests/disappointed with results
mini-mental test score: variable
global memory loss (dementia characteristically causes recent memory loss)
what is the DSM diagnostic criteria for depression
5/9 sx, nearly every day for at least 2 weeks:
- Depressed mood/ irritability (feels/appears sad or empty or teary)
- Anhedonia:
- Significant weight or appetite change.
4.Sleep alterations: Insomnia or hypersomnia. - Activity changes: Psychomotor agitation or retardation.
- Fatigue
- Guilt /worthlessness:
- Cognitive issues: think/ concentrate/ make decisions,
- Suicidality:
depression stepwise Mx
Mild:
* low-intensity therapy e.g. (CBT).
mod-sev
* higher-intensity CBT/interpersonal therapy
- and meds 1st line: (SSRI) sertraline.
- Immediate referral: in active suicidality,
- Refractory (tx resistant) depression - lithium/ Electroconvulsive Therapy (ECT).
SSRIs should be used with caution in young people, which SSRI
is suitable for children/ adolescents
fluoxetine
A
pt with ``Hx depression6 is on6 sertralin6e,
H`e recen6tly b5egan6 takin6g ib5uprofen6 due to a sports in6jury. what further medication n6eeds to b5e prescrib5ed?6
PPI
SSRIs commonly cause GI Sx as S/E, so PPI is needed when pt on SSRI & NSAID
(NICE: don’t prescribe SSRI &NSAID but if it has to be done, give PPI)
Give 4 drugs/drug groups which should cause in6teraction6s with `SSRIs
NSAIDS-inc aspirin (GI bleed risk)
warfarin/heparin (bleeding risk)
triptans (serotonin syndrome)
MOAIS (e.g. resegiline =- serotonin syndrome)
which SSRI should be avoided in pregnancy
Paroxetine
to avoid serotonin syndrome, how long should a pt waiting between stopping & starting MAOIs and SSRIs.
To avoid this, patients should be given a 14-day washout period between MAOIs and SSRIs.
what are the metabolic S/E of atypical antipsychotics
hyperlipidemia, hypercholesterolemia, hyperglycemia,hyperprolactinemia and weight gain.
typical- mainly EPSE & hyperprolactinaemia
atypical- less EPSE/hyperprolactinaemia, more of the other metabolic effects
give x2 examples of typical & atypical antipsychotics
typical: haloperidol, chlorpromazine
atypical: clozapine, risperidone, olanzapine
what 4 features make up EPSE for antipsychotics
- Parkinsonism
- acute dystonia - sustained muscle contraction (e.g. torticollis)
- akathisia (severe restlessness)
- tardive dyskinesia ( abnormal, involuntary, motions - most common is chewing and pouting of jaw)
what are the non- metabolic S/E of antipsychotics (excluding EPSE)
- antimuscarinic: dry mouth, blurred vision, urinary retention, constipation
- sedation, weight gain
- neuroleptic malignant syndrome: pyrexia, muscle stiffness
- reduced seizure threshold (greater with atypicals)
- prolonged QT interval (particularly haloperidol)
lithium
- therapeutic range
- excreted primarily by…..
0.4-1.0 mmol/L
primarily by the kidneys. - has a long plasma half-life being excreted