PSYC*2410 Chapter 3: Anatomy of the Nervous System Flashcards
What are the two divisions of the vertebrate nervous system?
- The central nervous system
- The peripheral nervous system
What is the central nervous system?
The portion of the nervous system located within the skull and spine (brain and spinal cord)
What is the peripheral nervous system?
The potion of the nervous system located outside the skull and spine
Which division of the PNS interacts with the external environment?
The somatic nervous system
Which division of the PNS that regulates the body’s internal environment?
The autonomic nervous system
The efferent nerves of the autonomic nervous system are further divided into what two systems?
- The sympathetic nervous system
- The parasympathetic nervous system
Which division of the nervous system stimulates, organizes, and mobilizes energy resources in threatening situations?
The sympathetic division
Which division of the nervous system acts to conserve energy?
The parasympathetic division
What does the relative activity of the opposing sympathetic and parasympathetic input control?
Each autonomic target organ
What are afferent nerves?
Nerves that carry sensory signals to the CNS
What are efferent nerves?
Nerves that carry signals from the CNS to the skeletal muscles (somatic NS) or internal organs (autonomic NS)
Which type of autonomic motor nerves project from the CNS in the lumbar and thoracic regions of the spinal cord?
Sympathetic nerves
Which type of autonomic motor nerves project from the brain to the sacral region of the spinal cord?
Parasympathetic nerves
When sympathetic neurons synapse on second-stage neurons, are they near or far from their target organs?
Far
When parasympathetic neurons synapse on second-stage neurons, are they near or far from their target organs?
Near
What are cranial nerves?
The nerves projecting from the brain
How many cranial nerves are there?
12 pairs (24 total)
What are the first two cranial nerves?
- Olfactory nerves
- Optic nerve
What are the longest cranial nerves?
The vagus nerves
Where do the vagus nerves travel?
To and from the gut
Are the autonomic motor fibres of cranial nerves sympathetic or parasympathetic?
Parasympathetic
What are the meninges?
The three protective membranes that cover the brain and spinal cord
From outermost to innermost, what are the three meninges?
- The dura mater
- The arachnoid membrane
- The pia mater
What is the subarachnoid space?
The space beneath the arachnoid membrane
What is contained within the subarachnoid space?
Large blood vessels and cerebrospinal fluid
Which of the three meninges adheres to the CNS?
The pia mater
What are the three interconnected structures filled with cerebrospinal fluid?
- The subarachnoid space
- The central canal
- The cerebral ventricles
What is the main role of the cerebrospinal fluid?
To protect and cushion the brain
What is the small CSF-filled channel that runs the length of the spinal cord?
The central canal
What are the CSF-filled internal chambers of the brain?
The cerebral ventricles
What are the four cerebral ventricles?
- Two lateral ventricles
- The third ventricle
- The fourth ventricle
What connects the third and fourth ventricle?
The cerebral aqueduct
What are the network of capillaries that protrude into the ventricles from the pia mater and produce CSF?
The choroid plexuses
What path does the CSF follow to be absorbed and drained?
Absorbed from the subarachnoid space into dural sinuses that run through the dura mater and drain into the jugular veins of the neck
What causes hydrocephalus?
A build up of fluid in the ventricles causes the walls of the ventricles, and thus the entire brain, to expand
What is the mechanism that impeded the passage of toxic substances from the blood into the brain?
The blood-brain barrier
What characteristic of the blood vessels in the brain creates an effective blood-brain barrier?
The blood vessel walls in the brain are composed of tightly packed cells that form a barrier to the passage of many molecules
T or F: The blood-brain barrier impedes the passage of all large molecules.
False, certain molecules can pass through
What are neurons?
Cells that are specialized for the reception, conduction, and transmission of electrochemical signals
What composes the neuron cell membrane?
A lipid bilayer
What is embedded within the neuron cell membrane?
Various proteins
How are neurons classified?
Based on the number of processes extending from their cell bodies
What are most neurons classified as?
Multipolar
Which type of neuron has more than two processes extending from its cell body?
Multipolar neurons
Which type of neuron only has one process extending from its cell body?
Unipolar neurons
Which type of neuron has two processes extending from its cell body?
Bipolar neurons
What are interneurons?
Neurons with short axons or no axons at all
What are the two kinds of gross neural structures in the nervous system?
- Those composed primarily of cell bodies
- Those composed primarily of axons
What are clusters of neuronal cell bodies in the CNS called?
Nuclei
What are ganglia?
Clusters of neuronal cell bodies in the PNS
What are tracts?
Bundles of axons in the CNS
What are bundles of axons in the PNS called?
Nerves
What are glial cells/glia?
The non-neuronal cells of the nervous system
What is the ratio of glia to neurons in the brain?
2:3
What are four types of glia?
- Oligodendrocytes
- Schwann cells
- Microglia
- Astrocytes
What are oligodendrocytes?
Glial cells that myelinate axons of the CNS
T or F: Each oligodendrocyte provides only one segment of myelination?
False, each oligodendrocyte provides multiple segments, often on more than one axon
What are schwann cells?
Glial cells that compose the myelin sheaths of the PNS axons
What do schwann cells promote?
The regeneration of PNS axons
Each schwann cell constitutes how many myelin segments?
One
What are microglia?
Glial cells that respond to injury or disease by engulfing cellular debris and triggering inflammatory responses
What are three things microglia play a role in?
- The regulation of cell death
- Synapse formation
- Synapse elimination
What are the largest and most studied glial cells?
Astrocytes
The extensions of which type of glial cell cover the outer surface of blood vessels that course through the brain?
Astrocytes
T or F: Some astrocytes make contact with neurons.
True
Which type of glial cell can exchange chemical signals, form functional networks, control the establishment and maintenance of synapses, control the blood-brain barrier, play a role in certain form of cognition, and more?
Astrocytes
What is the major problem in visualizing neurons?
They are so tightly packed and their axons and dendrites are so intertwined that looking through a microscope at unprepared neural tissue reveals very little
What is a golgi stain?
A neural stain that completely darkens a few neurons in a slice of tissue to reveal their silhouettes
What are golgi stains commonly used for?
To discover the overall shape of neurons
What is the main drawback to golgi stains?
They provide no indication of the number of neurons in an area
What is a nissl stain?
A neural stain that has an affinity for the structures in neuron cell bodies
Nissl dyes penetrate all cells on a slide, but they only bind to what?
They only bind to the most prevalent neuron in cell bodies (ex. DNA or RNA)
What is the most common dye used in the Nissl method?
Cresyl violet
When are Nissl types most commonly used?
To estimate the number of cell bodies in an area
What is the procedure for producing an electron microscopy?
Thin slices of neural tissue are coated with an electron-absorbing substance, then a beam of electrons is passed through the tissue onto a photographic film
What is one drawback of the electron microscopy?
The images are so detailed that it can be difficult to visualize general aspects of neuroanatomical structures
Are scanning electron microscopes capable of providing as much magnification as a conventional electron microscopy?
No
What are the two types of neuroanatomical tracing techniques?
- Anterograde
- Retrograde
Which type of neuroanatomical tracing methods are used when tracing the paths of axons projecting away from cell bodies?
Anterograde tracing methods
Which type of neuroanatomical tracing methods are used when tracing the paths of axons projecting away from cell bodies?
Retrograde tracing methods
Directions in the vertebrate nervous system are described in relation to what?
The orientation of the spinal cord
What are the three axes of the vertebrate nervous system?
- Anterior-posterior
- Dorsal-ventral
- Medial-lateral
Which direction is referred to as anterior?
Toward the nose end of a vertebrate
What is another word for rostral?
Anterior
Which direction is referred to as posterior?
Toward the tail end/ back of the head of a vertebrate
What is another word for caudal?
Posterior
Which direction is referred to as dorsal?
Toward the back surface of a vertebrate or toward the top of the head
Which direction is referred to as ventral?
Toward the chest surface of a vertebrate or toward the bottom of the head
Which direction is referred to as medial?
Toward the midline of the body of a vertebrate
Which direction is referred to as lateral?
Away from the midline of the body of a vertebrate
What does superior mean?
Toward the top of the primate heat or brain
What does inferior mean?
Toward the bottom of the primate head or brain
What are the three different planes of the brain?
- Horizontal
- Frontal
- Sagittal
What are horizontal brain sections?
Any slices of brain tissue cut in a plane parallel to the top of the brain
What are frontal brain sections?
Any slices of brain tissue cut in a plane that is parallel to the face
What is another word for coronal sections?
Frontal sections
What are sagittal brain sections?
Any slices of brain tissue cut in a plane that is parallel to the side of the brain
What is a midsagittal section?
A section cut down the centre of the brain, between the two hemispheres
What is a cross-section?
A section cut at a right angle to any long, narrow structure of the CNS (ex. The spinal cord or a nerve)
What are the two areas that comprise the spinal cord?
- An inner H-shaped core of gray matter
- A surrounding area of white matter
What is gray matter?
Portions of the nervous system that are composed largely of cell bodies and unmyelinated interneurons
What are the two dorsal arms of spinal gray matter?
The dorsal horns
What are the two ventral arms of spinal gray matter?
The ventral horns
What is white matter?
Portions of the nervous system composed largely of myelinated axons
What are spinal nerves?
Pairs of spinal nerves attached to the spinal cord
To how many levels of the spine are pairs of spinal nerves attached?
31 different levels
Each spinal nerve divides as it nears the cord, and its axons are joined to the cord via one of which two roots?
- The dorsal root
- The ventral root
Are all dorsal root axons sensory/afferent or motor/efferent?
Sensory/afferent
What do the cell bodies of dorsal root nerves grouped together just outside the spinal cord form?
The dorsal root ganglia
Are neurons of the dorsal root unipolar or multipolar?
Unipolar
Are all ventral root axons sensory/afferent or motor/efferent?
Motor/efferent
Are neurons of the ventral root unipolar or multipolar?
Multipolar
Where do the cell bodies of ventral root neurons reside?
In the ventral horns
Where do spinal nerves that are part of the somatic nervous system project?
To skeletal muscles
Where do spinal nerves that are part of the autonomic nervous system project?
To ganglia
What do the three swellings on the anterior end of the neural tube eventually develop into?
The adult forebrain. midbrain, and hindbrain
Before birth, which of the initial three swellings does not grow into two different swellings?
The midbrain
What are the five swellings that compose the developing brain at birth?
- The telencephalon
- The diencephalon
- The mesencephalon (midbrain)
- The metencephalon
- The myelencephalon (medulla)
Which of the five major divisions of the brain is the most posterior?
The myelencephalon
What is the myelencephalon largely composed of?
Tracts carrying signals between the brain and the body
In which of the five major divisions of the brain is the reticular formation?
The myelencephalon
What is the reticular formation?
A complex network of about 100 tiny nuclei
Which brain structure occupies the central core of the brain stem, from the posterior boundary of the myelencephalon to the anterior boundary of the midbrain?
The reticular formation
The various nuclei of which brain area are involved in arousal, sleep, attention, movement, maintenance of muscle tone and various cardiac, circulatory, and respiratory reflexes?
The reticular formation
What is the myelencephalon also referred to as?
The medulla
Which of the five major divisions of the brain contains the pons and cerebellum?
The metencephalon
What is the metencephalic structure that creates a bulge on the ventral surface of the brain stem?
The pons
What is the large, convoluted metencephalic structure on the brain stem’s dorsal surface?
The cerebellum
Which brain structure is thought to participate in the storage of memory of learned sensorimotor skills?
The cerebellum
Damage to which brain structure eliminates the ability to precisely control movements and adapt them to changing conditions?
The cerebellum
T or F: Cerebellar damage produces a variety of cognitive deficits.
True
What are the two structures that compose the mesencephalon?
- The tectum
- The tegmentum
What is the mesencephalon also referred to as?
The midbrain
What is the tectum?
The dorsal surface of the midbrain/mesencephalon
What are the two pairs of bumps that compose the mammalian tectum?
- The inferior colliculi
- The superior colliculi
What is the posterior pair of colliculi in the tectum called?
The inferior colliculi
Which pair of colliculi in the tectum have an auditory function?
The inferior colliculi
What is the anterior pair of colliculi in the tectum called?
The superior colliculi
Which pair of colliuli in the tectum receive major visual input and direct the body’s orientation toward or away from particular visual stimuli?
The superior colliculi
What is the tegmentum?
The ventral division of the midbrain/mesencephalon
What is contained within the tegmentum?
Parts of the reticular formation, tracts of passage, and three colourful structures
What are the three colourful structures contained in the tegmentum?
- The periaqueductal gray
- The substantia nigra
- The red nucleus
What is the periaqueductal gray?
The gray matter around the cerebral aqueduct
Which structure in the tegmentum plays a role in mediating the analgesic (pain-reducing) effects of opioid drugs?
The periaqueductal gray
What is the cerebral aqueduct?
The narrow channel connecting the third and fourth ventricles
Which structure in the tegmentum is a nucleus whose neurons project via the nigrostriatal pathway to the striatum of the basl ganglia?
The substantia nigra
Which tegmentum structureis part of the mesotelencephalic dopamine system?
The substantia nigra
The red nucleus of the tegmentum is a structure of which system?
The sensorimotor system
What are the two structures that compose the diencephalon?
- The thalamus
- The hypothalamus
What is the two-lobed diencephalic structure that constitutes the anterior end of the brain stem?
The thalamus
Where do the lobes of the thalamus sit?
One lobe sits on either side of the third ventricle
What is the massa intermedia?
The neural structure in the third ventricel that connects the two lobes of the thalamus
What are sensory relay nuclei?
Nuclei of the thalamus whose main function is to relay sensory signals to the appropriate areas of the cortex
What are the six-layered thalamic structures that receive input from the retinas and transmit their output to the primary visual cortex?
The lateral geniculate nuclei
Which thalamic nuclei receive input from the inferior colliculi and project it to the primary auditory cortex?
The auditory thalamic nuclei
Which thalamic nuclei are important relay stations in the somatosensory system?
The ventral posterior nuclei
T or F: Sensory relay nuclei are one-way streets
False
Which diencephalic structure is located just below the anterior portion of the thalamus?
The hypothalamus
Which diencephalic structure plays an important role in the regulation of several motivated behaviours?
The hypothalamus
How does the hypothalamus exert its effects?
By regulating the release of hormones from the pituitary glad
What are the three structure that appear on the inferior surface of the hypothalamus?
- The pituitary gland
- The optic chiasm
- The mammillary bodies
What is the X-shaped structure on the inferior surface of the diencephalon?
The optic chiasm
At what point do the optic nerves from each eye come together and decussate?
The optic chiasm
What does it mean for a nerve to decussate?
To cross over to the other side of the brain
Are decussating fibres said to be contralateral or ipsilateral?
Contralateral
What is the largest, most superior/dorsal of the brain’s five major divisions?
The telencephalon
Which of the five major brain divisions mediates the most complex functions?
The telencephalon
What is the cerebral cortex?
The convoluted layer of tissue that covers the cerebral hemispheres
Is the cerebral cortex mainly composed of myelinated or unmyelinated neurons?
Unmyelinated
What does it mean to be lissencephalic?
To have a cortex that is not convoluted
What are fissures?
The large furrows in a convoluted cortex
What is the longitudinal fissure?
The fissure that separates the two cerebral hemispheres
What are sulci?
The small furrows in a convoluted cortex
What are cerebral commissures?
Tracts that connect the left and right cerebral hemispheres
What is the largest cerebral commissure?
The corpus callosum
What are the two major landmarks on the lateral surface of each hemisphere?
- The central fissure
- The lateral fissure
Which fissure separates the frontal lobe from the parietal lobe?
The central fissure
Which fissure separates the temporal lobe from the frontal lobe?
The lateral fissure
What are the four lobes of each hemisphere?
- Frontal
- Parietal
- Temporal
- Occipital
What are the two distinct functional areas in each frontal lobe?
- The precentral gyrus and adjacent frontal cortex
- The frontal cortex, anterior to the motor cortex
Which functional area of the frontal lobe has motor function?
the precentral gyrus and adjacent frontal cortex
What role does the portion of the frontal cortex anterior to the motor cortex play?
Performs complex cognitive functions
What are the two large functional areas in each parietal lobe?
- The post central gyrus
- Posterior parts of the parietal lobes
What is the primary function of the postcentral gyrus in the parietal lobe?
Analyzing body sensations
What is the primary function of the posterior regions of the parietal lobe?
Perceiving the location of objects and our bodies
Which of the four brain lobes lies adjacent to the temples?
The temporal lobes
Which of the four brain lobes contains the hippocampus and amygdala?
The temporal lobes
What are the three general functional areas of the temporal cortex?
- The superior temporal gyrus
- The inferior temporal cortex
- The medial portion of temporal cortex
What is the superior temporal gyrus involved in?
Hearing and language
What is the inferior temporal cortex involved in?
Identifying complex patterns
Which of the four cerebral lobes is the most posterior?
The occipital lobe
The primary function of which cerebral lobe is visual?
The occipital lobe
T or F: The cerebral lobes are best thought of as functional units.
False
What are gyri?
The cortical ridges located between fissures or sulci
What is the largest gyri in the frontal lobes?
The precentral gyrus
What is the primary function of the precentral gyrus?
Motor
What is the largest gyri in the parietal lobes?
The postcentral gyrus
What is the primary function of the postcentral gyrus?
Somatosensory
What is the largest gyri in the temporal lobes?
The superior temporal gyrus
The neocortex constitutes how much of the cerebral cortex?
90%
What two categories do most neocotrical neurons fall into?
- Pyramidal cells
- Stellate cells
The six layers of neocortex differ from one another in terms of what three factors?
- Size
- Density
- The relative proportion of pyramidal and stellate cell bodies they contain
T or F: Many long axons and dendrites course vertically (at right angles to the corical layers) throught the neocortex.
True
Which type of cortical neurons are multipolar and have a large dendrite that extends toward the cortex surface?
Pyramidal cells
What are the star-shaped cortical interneurons called?
Stellate cells
What is the functional organization of the neocortex in vertical columns called?
Columnar organization
What is the limbic system?
A collection of interconnected nuclei and tracts that ring the thalamus
What is the limbic system involved in?
The regulation of motivated behaviours
What are the six major structures of the limbic system?
- The amygdala
- The hippocampus
- The cingulate cortex
- The fornix
- The septum
- The mammillary bodies
What is the basal ganglia?
A collection of subcortical nuclei
Which structure of the basal ganglia is the terminal of the dopaminergic nigrostriatal pathway?
The striatum
What two things make up the striatum?
- Caudate
- Putamen
Which structure of the basal ganglia is located between the putamen and thalamus?
The globus pallidus
Where does the stiatum’s major output go?
The globus pallidus
What does the basal ganglia play a role in?
The performance of voluntary motor responses and decision-making
Which disease is associated with the deterioration of the pathway from the substantia nigra of the midbrain to the stiatum of the basal ganglia?
Parkinson’s disease
Which part of the basal ganglia is in the medial portion of the ventral striatum?
The nucleus accumbens
What does the nucleus accumbens play a role in?
Plays a role in the rewarding effects of addictive drugs and other reinforcers