Psoriasis Flashcards
Epidemiology of psoriasis
2% worldwide
Peaks of Psoriasis
2 peaks:
- 20–30 Yrs
-50–60 Yrs.
Earlier in F
percentage of psoriasis patient with:
Nail changes
79%
percentage of psoriasis patient with PSA
30% +ve psoriatic arthritis
MC variant of Psoriasis
Chronic plaque psoriasis
Plaque psoriasis is MC in children followed by guttate
MC gene As/w PS
HLA-Cw6 (Strongest association)
= 90% of early onset, 50% of late-onset, widespread disease & ↑ recurrences
found in Ch6p
PSORS1 (Ch 6p + HLA-Cw6); 50% of Patients
Type 1 & 2 PS
+FHx, positive HLA-Cw6, Early-onset = Type I psoriasis
-FHx, negative HLA-Cw6, Late-onset = Type II psoriasis.
which gene As/w PSA and pustular Ps
HLA-B27
Gene As/w early onset along with HLA-cw6?
MHC-II Ag (DRB1*0701/2)
Gene As/w guttate & erthythrodermic Ps
HLA-B13 & HLA-B17
Gene As/w palmoplantar putsulosis.
HLA-B8, Bw35, Cw7, and DR3
Gene As/w generalized pustular psoriasis?
loss-of- function mutations in IL36RN (IL36R antagonist like DITRA)
Triggers for Ps
External triggering factors(trauma and sunburns)
Systemic triggering factors
-Infections: MC Strept esp. pharyngitis
- HIV
-↓Ca
-Psychogenic stress
-Drugs
-Alcohol consumption, smoking & obesity.
Drugs triggering Ps
TD-LIMBS
TNF inh,
Dupilumab, anti-PD-1
Lithium,
IFN, imiquimod,
antiMalarials,
β-blockers,
Steroids (rapid taper))
Rapid steroid taper triggers
pustular psoriasis & flares of plaque psoriasis
