(Ch108) AK, BCC & SCC Flashcards
percentage of Americans who develop NMSC
1/5
Risk factors for mortality in SCC
- Age
- White
- Male
- lip, ear and genitalia
Risk factors for mortality in BCC (rare)
Immunosuppressed
Nevoid BCC syndrome
what is the amount of cumulative exposure to sun for SCC
70K hrs
what is the amount of intermittent exposure to sun for BCC
10k hrs
percentage of people developing additional NMSC after SCC or BCC dx
30-50% in 5y
environmental RF specific to SCC
- Cumulative/occupational sun exposure
- HPV
- cigarette smoking
Risk factors for SCC and BCC
- ENVIRONMENTAL EXPOSURES
- PIGMENTARY PHENOTYPE
- GENETIC SYNDROMES
- PREDISPOSING CLINICAL SETTINGS
- IMMUNOSUPPRESSION
Mention environmental RF for BCC and SCC
- Cumulative/occupational sun exposure (SCC)
- Intermittent/recreational sun exposure (BCC)
- Other exposures to UV light (PUVA, tanning beds)
- Ionizing radiation
- Chemicals (arsenic)
- HPV (SCC)
- Cigarette smoking (SCC)
Mention pigmentary phenotypes RF for SCC and BCC
Fair skin
Always burns, never tans
Freckling
Red hair
Mention Genetic syndromes risk factors for SCC and BCC
- Xeroderma pigmentosum
- Oculocutaneous albinism
- Epidermodysplasia verruciformis (SCC)
- Dystrophic epidermolysis bullosa (primarily recessive) (SCC)
- Ferguson–Smith syndrome (SCC)
- Muir–Torre syndrome
- Nevoid basal cell carcinoma syndrome (BCC)
- Bazex and Rombo syndromes (BCC)
Mention Genetic syndromes risk factors for SCC only
- Epidermodysplasia verruciformis (SCC)
- Dystrophic epidermolysis bullosa (primarily recessive) (SCC)
- Ferguson–Smith syndrome (SCC)
Mention Genetic syndromes risk factors for BCC only
- Nevoid basal cell carcinoma syndrome (BCC)
2 . Bazex and Rombo syndromes (BCC)
clinical setting increasing risk for SCC
- Chronic non-healing wounds
- Longstanding DLE, LP (erosive) or lichen sclerosus
- Porokeratosis (especially linear)
clinical setting increasing risk for BCC
Nevus sebaceus
