Psoriasis Flashcards

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1
Q

Definition

A

A chronic autoimmune disease characterised by erythematous, scaly plaques

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2
Q

Name the 5 types of psoriasis

A
  • chronic plaque psoriasis (common type, symettrical plaques on extensor surfaces)
  • flexural (smooth, erythematous plaques on flexor regions)
  • guttate psoriasis (tear drop shaped plaques appear after a strep infection)
  • pustular
  • generalised/erythrogermic
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3
Q

Risk Factors

A
  • Drugs (BALI)
    Beta blockers, Anti-malarials, Lithium and Indomethacin/NSAIDs
  • Skin trauma
  • infection
  • FH
  • Steroid withdrawal
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4
Q

Presentation of chronic plaque psoriasis

A

S - extensor surfaces and scalp
C - bright red/pink
A - nail changes e.g. pitting, onycholysis, hyperkeratosis.
M - circular/oval elevated plaques, often have overlying white scale

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5
Q

differentials for a scaly rash

A

scabies
discoid eczema

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6
Q

Pathophysiology and its relation to treatment

A

The autoimmune reaction causes inflammation and hyperproliferation of keratinocytes.

Corticosteroids reduce inflammation
Vitamin B reduced keratinocyte proliferation

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7
Q

Name 4 methods of management

A

Topical treatment
Phototherapy
Systemic treatment
Biologics e.g. infliximab

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8
Q

Name the 4 topical treatments in the order of their stepwise approach

A

All pts must use emollients all the time

1st line - potent topical steroid e.g. Betnovate AND topical vitamin B e.g. Dovonex (apply at diff times)

2nd line - stop topical steroid and apply vitamin D twice daily

3rd line - stop topical vitamin D and apply steroid twice daily

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9
Q

Describe the 3 lines of systemic treatment

A

1st line - Methotrexate
2nd line - Ciclosporin
3rd line - Acitretin

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