psoriasis Flashcards
a disease characterized by papulosquamous skin lesions. it is a common, chronic and inflammatory disease. contains reddish or salmon coloured plaques covered with silvery scales. associated with punctate hemorrhage when removed (point like bleeding).
psoriasis
the pathophysiology of psoriasis is the dysregulation of the cell mediated _______ immune response
adaptive
which pathway over responds in psoriasis?
Th1
what cytokines are released that causes hyperproliferation of keratinocytes and formation of the psoriatic plaques
IL-12, IL-17 and IL-23
what environmental factors and disease states may cause psoriasis?
- streptococcal pharyngitis
- stressful life events
- low humidity
- HIV
- trauma, medications, cold, obesity
true/false: diets high in fish oils seem to be protective against the development of psoriasis
true
is psoriases present in the extensor or flexor areas of the body?
extensor e.g. elbows and knees
a subtype of psoriasis; ausptiz sign and koebners phenomenom. extensor diesase and on scalp. most common type of psoriasis
plaque-type psoriasis
a subtype of psoriasis; small, monomorphic sterile pustules surmounting painful, inflamed, red, papules. could present with fever and elevated WBC
pustular psoriasis
a subtype of psoriasis; can be seen in 50% of patients with psoriasis. usually associated with arthritis. psoriatic joint disease is present in about 90%.
psoriatic nails
a subtype of psoriasis; not specific to psoriasis. total body redness and peeling of the skin. massive skin shedding. hypothermia, infection, dehydration, protein loss, electrolytes
erythrodermic
true/false: blood work is generally not necessary for the determination os psoriasis
true
what is the first line treatment for mild-moderate psoriasis?
topical steroids
what are the most effective vehicles for psoriasis but they may stain clothing and bedding
ointments
