Pseudocholinesterase deficiency

Question 1

23M

Elective surgical procedure - Anesthesia — Prolonged paralysis

anesthesia was administrated with propofol , succinylcholine , fentanyl infusions

no return of neuromuscular function back

Mother also have problem - slow to wake up from anesthesia
why prolonged paralysis ??

Answer 1

After succinylcholine’s == prolonged paralysis

Pseudocholinesterase deficiency
Autosomal recessive disorder
genetic polymorphism in the BCHE gene

Question 2

cause of prolonged paralysis ?

Answer 2

dec plasma hydrolysis of succinylcholine

Question 3

function of Succinylcholine in intubution and surgery ?

Answer 3

skeletal muscle relax

Question 4

form and work of succinylcholine ?

Answer 4

depolarizing neuromuscular blocking agent
persistent depolarization

Question 5

redistribution to fat which drug ><

Answer 5

propofol

Question 6

if drug bind to plasma protein what will happen ?

Answer 6

dec the effect of the medication

Question 7

type of disease of pseudocholinesterase deficiency ?

Answer 7

autosomal recessive