PSC Flashcards

1
Q

Primary sclerosing cholangitis is associated with which other medical condition?

A

inflammatory bowel disease (ulcerative colitis)

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2
Q

Describe each stage of primary sclerosing cholangitis.

A

I-portal: portal edema, inflammation, ductal proliferation; II-periportal: periportal fibrosis +/- inflammation beyond limiting plate; III-septal: septal fibrosis, bridging necrosis or both; IV-cirrhotic: biliary cirrhosis

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3
Q

Where is the most common location for development of a dominant biliary stricture?

A

at or near hepatic duct bifurcation

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4
Q

What is the incidence of cholangiocarcinoma in patients with PSC?

A

10-15%

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5
Q

How is small duct PSC diagnosed?

A

liver biopsy

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6
Q

What serological abnormalizities can be found in patients with PSC?

A

antinuclear, antismooth muscle, anticardiolipin antibioties

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7
Q

What is the surgical procedure for patients with dominant strictures associated with PSC?

A

complete resection of extrahepatic biliary tree and reconstruction using Roux-en-Y hepaticojejunostomy +/- stent

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8
Q

What percentage of OLTs in the US are done for PSC?

A

5%

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9
Q

What percentage of patients recur after liver transplantation?

A

15-20%

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