PSC 2019 Lecture 5

Question 1

what are the effects of asbestos

Answer 1

asbestos fibres form spindles in the alveoli

Question 2

what happens during fibrosis

Answer 2

distance for gas exchange is increased which impairs lung function, the lungs also become smaller

Question 3

what do fibroblasts do

Answer 3

secrete collagen

Question 4

How many people live with IPF in the UK. How many people will die due to IPF in the uk

Answer 4

Over 30,000
1 in a 100

Question 5

what happens during IPF

Answer 5

the alveolar epithelium is damaged
there is an aberrant healing off the wound
pro fibrotic fibres are released
increased extracellular matrix deposition
impaired gas exchange, leading to respiratory failure

Question 6

what does pirfenidone do and what are its side effects

Answer 6

suppresses fibroblast proliferation via TGF-Beta inhibition

Question 7

what does Nintedanib
what are its side effects

Answer 7

triple TKI inhibitor

Question 8

which mucin was seen on a normal vs IPF volcano plot

Answer 8

MUC5B

Question 9

proteomics also revealed that there was reduced surfactant