PSA - Prescription Review Flashcards
Side Effects of Steroids
S - Stomach ulcer
T - Thin skin
E - OEdema
R - R + L sided HF
O - Osteoperosis
I - Infection (+ candida)
D - Diabetes (common hyperglycaemia, rare DM)
S - Syndrome of CUSHING’S!
Cytochrome P450 Inducers (need more drug)
Cytochrome P450 Inhibitors (risk of OD)
Inducer:
P - phenytoin
C - carbamezapine
B - barbituates
R - rifampicin
A - alcohol (chronic)
S - sulfonylureas
Inhibitor:
A - allopurinol
O - omeprazole
D - disulfiram
E - erythromcin
V - valporate
I - isoniozid
C - ciprofloxacin
E - ethanol (acute)
S - sulfonamides
Drugs to stop before Operations and when
I - insulin (variable dose)
L - Lithium (day before)
A - Anticoag and Antiplatelet (variable)
C - COCP/ HRT (4 weeks before)
K - K+ sparing diuretic (same day)
O - Oral hypoglycaemic agents (variable)
P - Perandopril/ ACEi (same day)
Method for reviewing a prescription
P - Patient details
Re - Reaction/ allergies
S - Sign the doc
C - Contra-indications
R - Route of med
I - Infusion needed?
B - Blood clot prophylaxis
E - Anti-emetic
R - Relief of pain
Common Contra-Indications to be aware of (4)
- Drugs which increase bleed risk
- Steroids
- NSAIDs
- Anti-hypertneisives
Side effects of anti-hypertensives
- All of them…
- B-blockers (3)
- ACEi (2)
- CCB - (2)
- Diuretics - generally!
Thiazide -
K+ sparing -
- All of them - postural hypotension
- B-blockers
- Bradycardia (good chronic HF but not good cute)
- Wheeze in asthmatics
- erectile dysf. - ACEi
- Dry cough
- Electrolyte disturbances inc. K+ and dec. Na+ - CCB
- Facial flushing
- peripheral oedema - Diuretics - Renal failure!
Thiazide - Gout
K+ sparing - Gynaecomastia
Doses of common anti-emetics for all routes!
Cyclizine -
Clopramide -
Cyclizine - 50mg 8 hrly
Clopramide - 10mg 8 hrly
Replacement fluids
Give 0.9% sodium chloride unless (3)
-
-
-
- Hypernatraemia or hypoglycaemia - 5% dextrose (hyoglycaemkc be thinking 10% 100ml over 15-20mins)
- Ascites - human albumin
- Shocked due to bleed - blood transfuse
IV Fluids
If showing signs of shock give -
If oliguric (not due to obstruction) give -
If showing signs of shock give - 500ml bolus then reasses
If oliguric (not due to obstruction) give - 1L over 2-4hrs
Rough guide to predicting fluid loss
500ml depleted if -
1L depleted if -
> 2Ldepleted if -
500ml depleted if - Oliguric (<30ml/hr UO) or anuric
1L depleted if - Tachy + Oliguric
> 2Ldepleted if - Shocked + Tachy + Oliguric
How much KCl should be added if U=Es are normal?
40mmol/day therefore (2 x 20mmol in 2 of the 3 bags)
REAL LIFE - 3 things you should do every time you prescribe fluids
- Check U+Es for additives
- Ausc. lungs, check ankles for overload
- Palpate bladder - retention
Blood clot prophylaxis
Prescribe what? drug/ class and route
Med prophylactic dose =
surgery prophlactic dose med risk = how long before surgery?
surgery prophlactic dose high risk = how long before surgery?
treatment dose is weight specific so look it up!
Contra-indications to prescribe this? (2)
Contra-indication for compression stockings? (1)
Prescribe what?
enoxiparin sodium s/c every
Med prophylactic dose = 40mg every 24 hours
surgery prophlactic dose med risk = 20mg 1 dose given 2hrs before surgery then 20mg every 24 hours
surgery prophlactic dose high risk = 40mg given 12 hrs before surgery and then 40mg every 24 hours
treatment dose is weight specific so look it up! (DOAC is better)
Contra-indications to prescribe this? (2)
- Bleed risk
- currently bleeding (including ischaemic stroke)
Contra-indication for compression stockings?
- PAD with ulcers
2 scenarios to avoid metoclopramide?
- PD patients - worsens symptoms
- Young females - causes dyskinesia (unwanted movements)
first-line anti-emetic for pretty much all scenarios?
dose/route/ hourly?
Scenario that it shouldn’t be used? (1)
- Its also avoided in the elderly due to what cause?
Instead give? dose and route and what hourly?
cyclizine 50mg 8 hourly IV/Oral/IM
Can cause fluid retention so don’t give in HF
Elderly- can cause confusion/ drowsiness due to anti-cholinergic properties/ burden
Metoclopramide 10mg 8 hourly IV/IM