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PHARMACOLOGY - 2 > PS+S receptors and effects > Flashcards

PS+S receptors and effects Flashcards

1
Q

Eye: sympathetic stimulation

A
  • Alpha 1: Dilate pupils by contraction of radial muscle, iris
  • Beta 2: relaxation of ciliary muscle (low levels unless large stimulation)
    o So can focus on distance!
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2
Q

Eye: parasympathetic stimulation

A
  • M3,M2: pupillary constriction by contraction of sphincter muscle, iris
  • M3, M2: contraction of ciliary muscle
    o So can focus on ‘food’ in front of you (close vision)
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3
Q

Glands of head: sympathetic stimulation

A
  • Alpha 1:
    o Lacrimal: increased secretion (‘dry’ secretion)
    o salivary: minor increased secretion (dry thick)
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4
Q

Glands of head: parasympathetic stimulation

A
  • M3
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5
Q

Lungs: sympathetic stimulation

A
  • Beta2: bronchiolar dilation by bronchiolar smooth muscle relaxation
  • *only if it is a REALLY BIG sympathetic stimulation
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6
Q

Lungs: parasympathetic stimulation

A
  • M3: bronchiolar contraction by contraction of bronchiolar smooth muscle
    o Don’t need to be breathing as much
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7
Q

Heart: sympathetic stimulation

A
  • Beta-1>beta-2
    o SA node=increased HR
    o Atria=increased contractility
    o AV node=increased conduction
    o Ventricle=increased contractility
  • *pacemakers and throughout! (effects HR and contractility readily)
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8
Q

Heart: parasympathetic stimulation

A
  • M3
    o SA node=decreased HR
    o Atria=decreased contractility
    o AV node=decreased conduction
    o Ventricle=decreased contractility
  • *mostly to pacemakers (not much to myocardium, primarily see HR effect)
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9
Q

Chronotropic

A
  • Increased HR
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10
Q

Inotropic

A
  • Increased contractility
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11
Q

Dromotropic

A
  • Increased conduction/speed
    o Purkinje and AV nodes
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12
Q

Lusotropic

A
  • Increased relaxation
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13
Q

Blood vessels (arteries and arterioles): low sympathetic stimulation (not much E released)

A

*only see alpha1 effects=constriction
- Coronary
- Pulmonary
- Skin and mucosa (no beta2)
- Skeletal muscle
- Abdominal viscera

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14
Q

Blood vessels (arteries and arterioles): high sympathetic stimulation

A

*stimulation of adrenals and increased E=alpha 1, but more beta2 =dilation
- Coronary
- Pulmonary
- Skeletal muscle
- Abdominal viscera
- (no beta2 in skin and mucosa)

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15
Q

Blood vessels (arteries and arterioles): parasympathetic stimulation

A
  • *dilation NOT due to PS stimulation
  • Only if give a drug and M2 is activated
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16
Q

GI tract: sympathetic stimulation

A
  • Alpha 2
    o Decreased motility
    o Inhibition of secretion
  • Alpha 1
    o Increased tone of sphincters
17
Q

GI tract: parasympathetic stimulation

A
  • M3
    o Increased motility
    o Decreased tone of sphincters
    o Increased stimulation
18
Q

Urinary bladder: sympathetic stimulation

A
  • Beta 2
    o Relaxation of detrusor muscle (wall of bladder) =less likely to squeeze out pee
  • Alpha 1
    o Contraction of sphincters
19
Q

Urinary bladder: parasympathetic stimulation

A
  • M3
    o Increased contraction of detrusor muscle (wall of bladder)
    o Relaxation of sphincters
20
Q

Sex organs: sympathetic stimulation

A
  • Alpah1 (male)
    o Ejaculation
  • None in female
21
Q

Sex organs: parasympathetic stimulation

A
  • M3
    o Erection in male and female
22
Q

Skin: sympathetic stimulation

A
  • Alpha 1
    o Sweat glands
    o Pilomotor muscles
  • horses =beta2!
23
Q

Adrenal medulla: sympathetic stimulation

A
  • Secretion of E from nicotinic receptors
24
Q

Kidney: sympathetic stimulation

A
  • Beta 1
    o Increase renin secretion
25
Q

Liver: sympathetic stimulation

A
  • Alpha 1
    o Glycogenolysis
  • Beta 2
    o Gluconeogenesis
26
Q

Splenic capsule: sympathetic stimulation

A
  • Alpha 1
    o Contraction
27
Q

Autonomic nerves, sympathetic nerves: sympathetic stimulation

A
  • Alpha 2
    o Inhibition of NE release from autoreceptor

PHARMACOLOGY - 2 (6 decks)

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