PRRs

Question 1

TLR1:TLR2 Heterodimer

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 1

Ligands: Lipopeptides, GPI

Cells: monocytes, DCs, eosinophils, basophils, mast cells

On Plasma Membrane

Question 2

TLR2:TLR6 Heterodimer

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 2

Ligands: Lipoteichoic acid, Zymosan

Cells: monocytes, DCs, eosiniphils, basophils, mast cells

On Plasma Membrane

Question 3

TLR3

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 3

Ligand: double stranded viral RNA

NK cells

Endosomes

Question 4

TLR4:TLR4 Homodimer

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 4

Ligand: lipopolysaccharide

Cells: macrophages, DCs, mast cells, eosinophils

Plasma Membrane

Question 5

TLR5

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 5

Ligand: Flagellin

Cells: Intestinal Epithelium

Plasma Membrane

Question 6

TLR7

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 6

Ligand: single stranded viral RNAs

Cells: plasmacytoid DCs, NK cells, eosinophils, B cells

Endosomes

Question 7

TLR8

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 7

Ligand: single stranded viral RNAs

Cells: NK cells

Endosomes

Question 8

TLR9

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 8

Ligand: unmethylated CpG-rich DNA

Cells: plasmacytoid DCs, B cells, eosinophils, basophils

Endosomes

Question 9

TLR10 homodimer and heterodimers with TLR1 and 2

What are the:

Ligand
Cells carrying receptor
Cellular Location of the receptor

Answer 9

Ligand: Uknown

Cells: plasmacytoid DCs, basophils, eosinophils, B cells

Question 10

Scavenger receptor PRR

What is…

Receptor
Microbial Ligand
Primary Function

Answer 10

Receptor: SR-AI, SR-AII

Ligand: anionic polymers

Function: macrophage