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HDM > Cytokines > Flashcards

Cytokines Flashcards

1
Q

Cell Source for Tumor Necrosis Factor (TNF)

A

Macrophages!!!

T cells
Mast cells

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2
Q

Cellular Targets and Biological effects of TNF

A

Endothelial cells: activation —> inflammation, coagulation

Neutrophils: activation

Hypothalamus: fever

Liver: synthesis of acute-phase proteins

Muscle, fat: catabolism

Many cell types: apoptosis

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3
Q

Cell source of IL-1

A

Macrophages!!!!

DCs
Endothelial Cells
Some epithelial cells
Mast cells

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4
Q

Cellular targets and biological effects of IL-1

A

Endothelial cells: activation —> inflammation, coagulation

Hypothalamus: fever

Liver: synthesis of acute phase proteins

T cells: Th17 differentiation

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5
Q

Cell source of Chemokines

A

Macrophages!!!!

DCs
Endothelial cells
T. Cells
Fibroblasts
Platelets
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6
Q

Cellular targets and biological effects of Chemokines

A

Leukocytes: increased integrity affinity, chemotaxis, activation

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7
Q

Cell source of IL12

A

Macrophages!!!

DCs

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8
Q

Cellular targets and biological effects of IL12

A

NK cells and T cells: INFy production, increased cytotoxic activity

T cells: Th1 differentiation

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9
Q

Cell source of Type I IFNs

A

IFNa: macrophages!!!, DCs

IFNb:fibroblasts

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10
Q

Cellular targets and biologic effects of Type I IFNs

A

All cells: antiviral state, increased class I MHC expression

NK cells: activation

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11
Q

Cell source of IL10

ANTI INFLAMMATORY

A

Macrophages!!

DCs
T cells

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12
Q

Cellular targets and biologic effects of IL10

A

Macrophages, DCs: inhibition of cytokines and chemokine production, reduced expression of costimulators and class II MHC

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13
Q

Cell source of IFNy

A

NK cells

T cells

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14
Q

Cellular targets and biologic effects of IFNy

A

Activation of macrophages

Stimulation of some antibody responses

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15
Q

Cell source of IL6

A

Macrophages!!!

Endothelial cells
T cells

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16
Q

Cellular targets and biologic effects of IL6

A

Liver: synthesis of acute phase proteins

B cells: proliferation of antibody producing cells

17
Q

Cell source of IL15

A

Macrophages

Others

18
Q

Cellular targets and biologic effects of IL15

A

NK cell proliferation

T cell proliferation

19
Q

Cell source of IL18

A

Macrophages

20
Q

Cellular targets and biologic effects of IL18

A

NK cell and T cells: IFNy synthesis

21
Q

Cell source of TGF-B

ANTI INFLAMMATORY

A

Macrophages !!!

Many cell types

22
Q

Cellular targets and biologic effects of TGF-B

A

Inhibition of inflammation

T cells: differentiation of Th17, regulatory T cells

HDM (4 decks)

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