Protooncogenes and Tumor Supressor Genes

Question 1

PDGFB overexpression

Answer 1

Astrocytoma - autocrine loop

Question 2

ERBB2 (Her2/Neu) Amplification - epidermal growth factor receptor

Answer 2

Subset of Breast CA - Trastuzumab

Question 3

RET pt. mt. - neural GFR

Answer 3

1. MEN2A
2. MEN2B
3. Sporadic medullary CA of thyroid

Question 4

KIT pt. mt - stem cell GFR

Answer 4

GI stromal tumor

Question 5

RAS - GTP binding protein - point mutation

Answer 5

1. Carcinoma
2. Melanoma
3. Lymphoma

Question 6

ABL - YK {t(9;22) w/ BCR}

Answer 6

1. CML

2. some types of adult ALL (Ph+) - poor prognosis

Question 7

c-MYC - TF - t(8;14) involving IgH

Answer 7

Burkitt lymphoma - starry sky

Question 8

N-MYC - Amplification

Answer 8

Neuroblastoma

Question 9

L-MYC - Amplification

Answer 9

Lung CA (small cell)

Question 10

CCND1 (cyclin D1) - t(11;14) involving IgH

Answer 10

Mantle cell lymphoma (B-cells)

Question 11

CDK4 amplification

Answer 11

Melanoma

Question 12

Bcl2 overexpression

Answer 12

Follicular lymphoma t(14;18)

Question 13

Germline Rb mutation

Answer 13

1. Familial retinoblastoma - bilateral

2. Osteosarcoma